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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GIRK1
Full Name:
G protein-activated inward rectifier potassium channel 1
Alias:
Inward rectifier K channel Kir3.1; Inward rectifier K(+) channel Kir3.1; IRK3; KCNJ3; KGA; Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3; Potassium channel, inwardly rectifying, subfamily J, member 3; Potassium inwardly-rectifying channel, subfamily J, member 3
Type:
Channel, potassium
Mass (Da):
56603
Number AA:
501
UniProt ID:
P48549
International Prot ID:
IPI00010176
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0015467
GO:0030955
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
R
R
K
F
G
D
D
Y
Q
V
V
T
T
S
S
Site 2
T16
G
D
D
Y
Q
V
V
T
T
S
S
S
G
S
G
Site 3
S18
D
Y
Q
V
V
T
T
S
S
S
G
S
G
L
Q
Site 4
S20
Q
V
V
T
T
S
S
S
G
S
G
L
Q
P
Q
Site 5
S22
V
T
T
S
S
S
G
S
G
L
Q
P
Q
G
P
Site 6
S62
V
Q
H
G
N
L
G
S
E
T
S
R
Y
L
S
Site 7
T64
H
G
N
L
G
S
E
T
S
R
Y
L
S
D
L
Site 8
S65
G
N
L
G
S
E
T
S
R
Y
L
S
D
L
F
Site 9
Y67
L
G
S
E
T
S
R
Y
L
S
D
L
F
T
T
Site 10
S69
S
E
T
S
R
Y
L
S
D
L
F
T
T
L
V
Site 11
T73
R
Y
L
S
D
L
F
T
T
L
V
D
L
K
W
Site 12
T74
Y
L
S
D
L
F
T
T
L
V
D
L
K
W
R
Site 13
T121
K
A
H
V
G
N
Y
T
P
C
V
A
N
V
Y
Site 14
T143
F
F
I
E
T
E
A
T
I
G
Y
G
Y
R
Y
Site 15
Y150
T
I
G
Y
G
Y
R
Y
I
T
D
K
C
P
E
Site 16
T152
G
Y
G
Y
R
Y
I
T
D
K
C
P
E
G
I
Site 17
S185
G
C
M
F
I
K
M
S
Q
P
K
K
R
A
E
Site 18
T193
Q
P
K
K
R
A
E
T
L
M
F
S
E
H
A
Site 19
S203
F
S
E
H
A
V
I
S
M
R
D
G
K
L
T
Site 20
T210
S
M
R
D
G
K
L
T
L
M
F
R
V
G
N
Site 21
S221
R
V
G
N
L
R
N
S
H
M
V
S
A
Q
I
Site 22
S225
L
R
N
S
H
M
V
S
A
Q
I
R
C
K
L
Site 23
T238
K
L
L
K
S
R
Q
T
P
E
G
E
F
L
P
Site 24
S278
C
H
V
I
D
A
K
S
P
F
Y
D
L
S
Q
Site 25
Y281
I
D
A
K
S
P
F
Y
D
L
S
Q
R
S
M
Site 26
S284
K
S
P
F
Y
D
L
S
Q
R
S
M
Q
T
E
Site 27
S315
M
T
C
Q
A
R
T
S
Y
T
E
D
E
V
L
Site 28
Y316
T
C
Q
A
R
T
S
Y
T
E
D
E
V
L
W
Site 29
Y342
E
G
F
F
K
V
D
Y
S
Q
F
H
A
T
F
Site 30
T348
D
Y
S
Q
F
H
A
T
F
E
V
P
T
P
P
Site 31
T353
H
A
T
F
E
V
P
T
P
P
Y
S
V
K
E
Site 32
S357
E
V
P
T
P
P
Y
S
V
K
E
Q
E
E
M
Site 33
S369
E
E
M
L
L
M
S
S
P
L
I
A
P
A
I
Site 34
S385
N
S
K
E
R
H
N
S
V
E
C
L
D
G
L
Site 35
T396
L
D
G
L
D
D
I
T
T
K
L
P
S
K
L
Site 36
T397
D
G
L
D
D
I
T
T
K
L
P
S
K
L
Q
Site 37
S401
D
I
T
T
K
L
P
S
K
L
Q
K
I
T
G
Site 38
T407
P
S
K
L
Q
K
I
T
G
R
E
D
F
P
K
Site 39
S420
P
K
K
L
L
R
M
S
S
T
T
S
E
K
A
Site 40
S421
K
K
L
L
R
M
S
S
T
T
S
E
K
A
Y
Site 41
T422
K
L
L
R
M
S
S
T
T
S
E
K
A
Y
S
Site 42
T423
L
L
R
M
S
S
T
T
S
E
K
A
Y
S
L
Site 43
S424
L
R
M
S
S
T
T
S
E
K
A
Y
S
L
G
Site 44
Y428
S
T
T
S
E
K
A
Y
S
L
G
D
L
P
M
Site 45
S429
T
T
S
E
K
A
Y
S
L
G
D
L
P
M
K
Site 46
S441
P
M
K
L
Q
R
I
S
S
V
P
G
N
S
E
Site 47
S442
M
K
L
Q
R
I
S
S
V
P
G
N
S
E
E
Site 48
S447
I
S
S
V
P
G
N
S
E
E
K
L
V
S
K
Site 49
S453
N
S
E
E
K
L
V
S
K
T
T
K
M
L
S
Site 50
S460
S
K
T
T
K
M
L
S
D
P
M
S
Q
S
V
Site 51
S464
K
M
L
S
D
P
M
S
Q
S
V
A
D
L
P
Site 52
S466
L
S
D
P
M
S
Q
S
V
A
D
L
P
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation