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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC34
Full Name:
Ubiquitin-conjugating enzyme E2 R1
Alias:
Ubiquitin-protein ligase R1
Type:
Enzyme
Mass (Da):
26737
Number AA:
236
UniProt ID:
P49427
International Prot ID:
IPI00027120
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0006270
GO:0000082
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y52
I
F
G
P
P
N
T
Y
Y
E
G
G
Y
F
K
Site 2
Y53
F
G
P
P
N
T
Y
Y
E
G
G
Y
F
K
A
Site 3
Y57
N
T
Y
Y
E
G
G
Y
F
K
A
R
L
K
F
Site 4
Y68
R
L
K
F
P
I
D
Y
P
Y
S
P
P
A
F
Site 5
Y70
K
F
P
I
D
Y
P
Y
S
P
P
A
F
R
F
Site 6
S71
F
P
I
D
Y
P
Y
S
P
P
A
F
R
F
L
Site 7
S106
P
P
V
D
D
P
Q
S
G
E
L
P
S
E
R
Site 8
S111
P
Q
S
G
E
L
P
S
E
R
W
N
P
T
Q
Site 9
T117
P
S
E
R
W
N
P
T
Q
N
V
R
T
I
L
Site 10
T136
S
L
L
N
E
P
N
T
F
S
P
A
N
V
D
Site 11
S138
L
N
E
P
N
T
F
S
P
A
N
V
D
A
S
Site 12
Y161
S
K
G
K
D
R
E
Y
T
D
I
I
R
K
Q
Site 13
T162
K
G
K
D
R
E
Y
T
D
I
I
R
K
Q
V
Site 14
Y190
V
P
T
T
L
A
E
Y
C
V
K
T
K
A
P
Site 15
S203
A
P
A
P
D
E
G
S
D
L
F
Y
D
D
Y
Site 16
Y207
D
E
G
S
D
L
F
Y
D
D
Y
Y
E
D
G
Site 17
Y210
S
D
L
F
Y
D
D
Y
Y
E
D
G
E
V
E
Site 18
Y211
D
L
F
Y
D
D
Y
Y
E
D
G
E
V
E
E
Site 19
S222
E
V
E
E
E
A
D
S
C
F
G
D
D
E
D
Site 20
S231
F
G
D
D
E
D
D
S
G
T
E
E
S
_
_
Site 21
T233
D
D
E
D
D
S
G
T
E
E
S
_
_
_
_
Site 22
S236
D
D
S
G
T
E
E
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation