KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
NUMB
Full Name:
Protein numb homolog
Alias:
H-Numb; Numb; Numb protein homolog; Protein S171
Type:
Cell development/differentiation; Tumor suppressor
Mass (Da):
70804
Number AA:
651
UniProt ID:
P49757
International Prot ID:
IPI00028059
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
N
K
L
R
Q
S
F
R
R
K
K
D
V
Site 2
Y15
F
R
R
K
K
D
V
Y
V
P
E
A
S
R
P
Site 3
S20
D
V
Y
V
P
E
A
S
R
P
H
Q
W
Q
T
Site 4
T34
T
D
E
E
G
V
R
T
G
K
C
S
F
P
V
Site 5
S38
G
V
R
T
G
K
C
S
F
P
V
K
Y
L
G
Site 6
Y43
K
C
S
F
P
V
K
Y
L
G
H
V
E
V
D
Site 7
S91
V
K
A
V
L
W
V
S
A
D
G
L
R
V
V
Site 8
T102
L
R
V
V
D
E
K
T
K
D
L
I
V
D
Q
Site 9
S115
D
Q
T
I
E
K
V
S
F
C
A
P
D
R
N
Site 10
S128
R
N
F
D
R
A
F
S
Y
I
C
R
D
G
T
Site 11
Y129
N
F
D
R
A
F
S
Y
I
C
R
D
G
T
T
Site 12
T150
C
F
M
A
V
K
D
T
G
E
R
L
S
H
A
Site 13
S155
K
D
T
G
E
R
L
S
H
A
V
G
C
A
F
Site 14
T179
R
E
K
E
C
G
V
T
A
T
F
D
A
S
R
Site 15
T181
K
E
C
G
V
T
A
T
F
D
A
S
R
T
T
Site 16
T187
A
T
F
D
A
S
R
T
T
F
T
R
E
G
S
Site 17
T188
T
F
D
A
S
R
T
T
F
T
R
E
G
S
F
Site 18
T190
D
A
S
R
T
T
F
T
R
E
G
S
F
R
V
Site 19
S194
T
T
F
T
R
E
G
S
F
R
V
T
T
A
T
Site 20
T198
R
E
G
S
F
R
V
T
T
A
T
E
Q
A
E
Site 21
T199
E
G
S
F
R
V
T
T
A
T
E
Q
A
E
R
Site 22
T201
S
F
R
V
T
T
A
T
E
Q
A
E
R
E
E
Site 23
T235
S
S
V
A
P
G
N
T
A
P
S
P
S
S
P
Site 24
S238
A
P
G
N
T
A
P
S
P
S
S
P
T
S
P
Site 25
S240
G
N
T
A
P
S
P
S
S
P
T
S
P
T
S
Site 26
S241
N
T
A
P
S
P
S
S
P
T
S
P
T
S
D
Site 27
T243
A
P
S
P
S
S
P
T
S
P
T
S
D
A
T
Site 28
S244
P
S
P
S
S
P
T
S
P
T
S
D
A
T
T
Site 29
T246
P
S
S
P
T
S
P
T
S
D
A
T
T
S
L
Site 30
S247
S
S
P
T
S
P
T
S
D
A
T
T
S
L
E
Site 31
T250
T
S
P
T
S
D
A
T
T
S
L
E
M
N
N
Site 32
T251
S
P
T
S
D
A
T
T
S
L
E
M
N
N
P
Site 33
S276
E
Q
L
A
R
Q
G
S
F
R
G
F
P
A
L
Site 34
S284
F
R
G
F
P
A
L
S
Q
K
M
S
P
F
K
Site 35
S288
P
A
L
S
Q
K
M
S
P
F
K
R
Q
L
S
Site 36
S295
S
P
F
K
R
Q
L
S
L
R
I
N
E
L
P
Site 37
T304
R
I
N
E
L
P
S
T
M
Q
R
K
T
D
F
Site 38
T309
P
S
T
M
Q
R
K
T
D
F
P
I
K
N
A
Site 39
S326
E
V
E
G
E
A
E
S
I
S
S
L
C
S
Q
Site 40
S329
G
E
A
E
S
I
S
S
L
C
S
Q
I
T
N
Site 41
T335
S
S
L
C
S
Q
I
T
N
A
F
S
T
P
E
Site 42
S339
S
Q
I
T
N
A
F
S
T
P
E
D
P
F
S
Site 43
T340
Q
I
T
N
A
F
S
T
P
E
D
P
F
S
S
Site 44
S346
S
T
P
E
D
P
F
S
S
A
P
M
T
K
P
Site 45
T363
V
V
A
P
Q
S
P
T
F
Q
A
N
G
T
D
Site 46
S371
F
Q
A
N
G
T
D
S
A
F
H
V
L
A
K
Site 47
T394
V
A
M
P
V
R
E
T
N
P
W
A
H
A
P
Site 48
T411
A
N
K
E
I
A
A
T
C
S
G
T
E
W
G
Site 49
S413
K
E
I
A
A
T
C
S
G
T
E
W
G
Q
S
Site 50
S420
S
G
T
E
W
G
Q
S
S
G
A
A
S
P
G
Site 51
S421
G
T
E
W
G
Q
S
S
G
A
A
S
P
G
L
Site 52
S425
G
Q
S
S
G
A
A
S
P
G
L
F
Q
A
G
Site 53
T436
F
Q
A
G
H
R
R
T
P
S
E
A
D
R
W
Site 54
S438
A
G
H
R
R
T
P
S
E
A
D
R
W
L
E
Site 55
S448
D
R
W
L
E
E
V
S
K
S
V
R
A
Q
Q
Site 56
S450
W
L
E
E
V
S
K
S
V
R
A
Q
Q
P
Q
Site 57
S459
R
A
Q
Q
P
Q
A
S
A
A
P
L
Q
P
V
Site 58
T473
V
L
Q
P
P
P
P
T
A
I
S
Q
P
A
S
Site 59
S476
P
P
P
P
T
A
I
S
Q
P
A
S
P
F
Q
Site 60
S480
T
A
I
S
Q
P
A
S
P
F
Q
G
N
A
F
Site 61
S553
Q
A
A
H
P
H
Q
S
P
S
L
V
R
Q
Q
Site 62
S555
A
H
P
H
Q
S
P
S
L
V
R
Q
Q
T
F
Site 63
T561
P
S
L
V
R
Q
Q
T
F
P
H
Y
E
A
S
Site 64
Y565
R
Q
Q
T
F
P
H
Y
E
A
S
S
A
T
T
Site 65
S568
T
F
P
H
Y
E
A
S
S
A
T
T
S
P
F
Site 66
S569
F
P
H
Y
E
A
S
S
A
T
T
S
P
F
F
Site 67
S573
E
A
S
S
A
T
T
S
P
F
F
K
P
P
A
Site 68
S586
P
A
Q
H
L
N
G
S
A
A
F
N
G
V
D
Site 69
S599
V
D
D
G
R
L
A
S
A
D
R
H
T
E
V
Site 70
T604
L
A
S
A
D
R
H
T
E
V
P
T
G
T
C
Site 71
S627
W
A
A
L
E
N
K
S
K
Q
R
T
N
P
S
Site 72
T631
E
N
K
S
K
Q
R
T
N
P
S
P
T
N
P
Site 73
S634
S
K
Q
R
T
N
P
S
P
T
N
P
F
S
S
Site 74
T636
Q
R
T
N
P
S
P
T
N
P
F
S
S
D
L
Site 75
S640
P
S
P
T
N
P
F
S
S
D
L
Q
K
T
F
Site 76
S641
S
P
T
N
P
F
S
S
D
L
Q
K
T
F
E
Site 77
T646
F
S
S
D
L
Q
K
T
F
E
I
E
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation