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Updated November 2019
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Protein Info
Short Name:
RanBP2
Full Name:
E3 SUMO-protein ligase RanBP2
Alias:
358 kDa nucleoporin; E3 SUMO-protein ligase RanBP2; Nuclear pore complex protein Nup358; Nucleoporin Nup358; NUP358; P270; RAN binding protein 2; Ran-binding protein 2; RBP2
Type:
SUMO conjugating system; Nucleoporin; Adaptor/scaffold; Ligase
Mass (Da):
358199
Number AA:
3224
UniProt ID:
P49792
International Prot ID:
IPI00221325
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005643
Uniprot
OncoNet
Molecular Function:
GO:0008536
GO:0003755
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0019941
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
S
K
A
D
V
E
R
Y
I
A
S
V
Q
G
S
Site 2
S14
D
V
E
R
Y
I
A
S
V
Q
G
S
T
P
S
Site 3
S18
Y
I
A
S
V
Q
G
S
T
P
S
P
R
Q
K
Site 4
T19
I
A
S
V
Q
G
S
T
P
S
P
R
Q
K
S
Site 5
S21
S
V
Q
G
S
T
P
S
P
R
Q
K
S
M
K
Site 6
S26
T
P
S
P
R
Q
K
S
M
K
G
F
Y
F
A
Site 7
Y31
Q
K
S
M
K
G
F
Y
F
A
K
L
Y
Y
E
Site 8
Y36
G
F
Y
F
A
K
L
Y
Y
E
A
K
E
Y
D
Site 9
Y42
L
Y
Y
E
A
K
E
Y
D
L
A
K
K
Y
I
Site 10
Y48
E
Y
D
L
A
K
K
Y
I
C
T
Y
I
N
V
Site 11
Y52
A
K
K
Y
I
C
T
Y
I
N
V
Q
E
R
D
Site 12
Y70
H
R
F
L
G
L
L
Y
E
L
E
E
N
T
D
Site 13
S86
A
V
E
C
Y
R
R
S
V
E
L
N
P
T
Q
Site 14
T92
R
S
V
E
L
N
P
T
Q
K
D
L
V
L
K
Site 15
Y116
V
T
D
G
R
A
K
Y
W
L
E
R
A
A
K
Site 16
S128
A
A
K
L
F
P
G
S
P
A
I
Y
K
L
K
Site 17
Y132
F
P
G
S
P
A
I
Y
K
L
K
E
Q
L
L
Site 18
Y159
D
L
I
Q
S
E
L
Y
V
R
P
D
D
V
H
Site 19
Y175
N
I
R
L
V
E
V
Y
R
S
T
K
R
L
K
Site 20
T178
L
V
E
V
Y
R
S
T
K
R
L
K
D
A
V
Site 21
S199
E
R
N
I
A
L
R
S
S
L
E
W
N
S
C
Site 22
S200
R
N
I
A
L
R
S
S
L
E
W
N
S
C
V
Site 23
S205
R
S
S
L
E
W
N
S
C
V
V
Q
T
L
K
Site 24
S217
T
L
K
E
Y
L
E
S
L
Q
C
L
E
S
D
Site 25
S223
E
S
L
Q
C
L
E
S
D
K
S
D
W
R
A
Site 26
S226
Q
C
L
E
S
D
K
S
D
W
R
A
T
N
T
Site 27
T231
D
K
S
D
W
R
A
T
N
T
D
L
L
L
A
Site 28
S248
N
L
M
L
L
T
L
S
T
R
D
V
Q
E
S
Site 29
S255
S
T
R
D
V
Q
E
S
R
E
L
L
Q
S
F
Site 30
S261
E
S
R
E
L
L
Q
S
F
D
S
A
L
Q
S
Site 31
S264
E
L
L
Q
S
F
D
S
A
L
Q
S
V
K
S
Site 32
S268
S
F
D
S
A
L
Q
S
V
K
S
L
G
G
N
Site 33
S271
S
A
L
Q
S
V
K
S
L
G
G
N
D
E
L
Site 34
S279
L
G
G
N
D
E
L
S
A
T
F
L
E
M
K
Site 35
T281
G
N
D
E
L
S
A
T
F
L
E
M
K
G
H
Site 36
S305
L
K
M
G
Q
H
S
S
N
V
Q
W
R
A
L
Site 37
S352
M
M
A
C
D
R
L
S
Q
S
G
H
M
L
L
Site 38
S354
A
C
D
R
L
S
Q
S
G
H
M
L
L
N
L
Site 39
S362
G
H
M
L
L
N
L
S
R
G
K
Q
D
F
L
Site 40
T375
F
L
K
E
I
V
E
T
F
A
N
K
S
G
Q
Site 41
S380
V
E
T
F
A
N
K
S
G
Q
S
A
L
Y
D
Site 42
Y386
K
S
G
Q
S
A
L
Y
D
A
L
F
S
S
Q
Site 43
S392
L
Y
D
A
L
F
S
S
Q
S
P
K
D
T
S
Site 44
S394
D
A
L
F
S
S
Q
S
P
K
D
T
S
F
L
Site 45
T398
S
S
Q
S
P
K
D
T
S
F
L
G
S
D
D
Site 46
S399
S
Q
S
P
K
D
T
S
F
L
G
S
D
D
I
Site 47
S403
K
D
T
S
F
L
G
S
D
D
I
G
N
I
D
Site 48
T420
E
P
E
L
E
D
L
T
R
Y
D
V
G
A
I
Site 49
Y422
E
L
E
D
L
T
R
Y
D
V
G
A
I
R
A
Site 50
S433
A
I
R
A
H
N
G
S
L
Q
H
L
T
W
L
Site 51
T473
H
E
T
S
R
L
E
T
N
A
P
E
S
I
C
Site 52
S505
Q
L
K
E
K
C
N
S
H
H
S
S
Y
Q
P
Site 53
S587
E
C
L
Q
K
T
G
S
G
L
N
S
F
Y
D
Site 54
S591
K
T
G
S
G
L
N
S
F
Y
D
Q
R
E
Y
Site 55
Y593
G
S
G
L
N
S
F
Y
D
Q
R
E
Y
I
G
Site 56
Y598
S
F
Y
D
Q
R
E
Y
I
G
R
S
V
H
Y
Site 57
Y605
Y
I
G
R
S
V
H
Y
W
K
K
V
L
P
L
Site 58
Y646
Q
A
S
E
I
V
E
Y
E
E
D
A
H
I
T
Site 59
T669
G
N
I
E
D
A
V
T
A
F
E
S
I
K
S
Site 60
S700
D
I
E
N
D
A
L
S
P
E
E
Q
E
E
C
Site 61
Y710
E
Q
E
E
C
K
N
Y
L
R
K
T
R
D
Y
Site 62
Y717
Y
L
R
K
T
R
D
Y
L
I
K
I
I
D
D
Site 63
S727
K
I
I
D
D
S
D
S
N
L
S
V
V
K
K
Site 64
S730
D
D
S
D
S
N
L
S
V
V
K
K
L
P
V
Site 65
S741
K
L
P
V
P
L
E
S
V
K
E
M
L
N
S
Site 66
S748
S
V
K
E
M
L
N
S
V
M
Q
E
L
E
D
Site 67
Y756
V
M
Q
E
L
E
D
Y
S
E
G
G
P
L
Y
Site 68
S757
M
Q
E
L
E
D
Y
S
E
G
G
P
L
Y
K
Site 69
Y763
Y
S
E
G
G
P
L
Y
K
N
G
S
L
R
N
Site 70
S767
G
P
L
Y
K
N
G
S
L
R
N
A
D
S
E
Site 71
S773
G
S
L
R
N
A
D
S
E
I
K
H
S
T
P
Site 72
S778
A
D
S
E
I
K
H
S
T
P
S
P
T
R
Y
Site 73
T779
D
S
E
I
K
H
S
T
P
S
P
T
R
Y
S
Site 74
S781
E
I
K
H
S
T
P
S
P
T
R
Y
S
L
S
Site 75
T783
K
H
S
T
P
S
P
T
R
Y
S
L
S
P
S
Site 76
Y785
S
T
P
S
P
T
R
Y
S
L
S
P
S
K
S
Site 77
S786
T
P
S
P
T
R
Y
S
L
S
P
S
K
S
Y
Site 78
S788
S
P
T
R
Y
S
L
S
P
S
K
S
Y
K
Y
Site 79
S790
T
R
Y
S
L
S
P
S
K
S
Y
K
Y
S
P
Site 80
S792
Y
S
L
S
P
S
K
S
Y
K
Y
S
P
K
T
Site 81
Y793
S
L
S
P
S
K
S
Y
K
Y
S
P
K
T
P
Site 82
Y795
S
P
S
K
S
Y
K
Y
S
P
K
T
P
P
R
Site 83
S796
P
S
K
S
Y
K
Y
S
P
K
T
P
P
R
W
Site 84
T799
S
Y
K
Y
S
P
K
T
P
P
R
W
A
E
D
Site 85
S832
M
Q
E
L
K
L
N
S
S
N
S
A
S
P
H
Site 86
S833
Q
E
L
K
L
N
S
S
N
S
A
S
P
H
R
Site 87
S835
L
K
L
N
S
S
N
S
A
S
P
H
R
W
P
Site 88
S837
L
N
S
S
N
S
A
S
P
H
R
W
P
T
E
Site 89
T843
A
S
P
H
R
W
P
T
E
N
Y
G
P
D
S
Site 90
Y846
H
R
W
P
T
E
N
Y
G
P
D
S
V
P
D
Site 91
S850
T
E
N
Y
G
P
D
S
V
P
D
G
Y
Q
G
Site 92
Y855
P
D
S
V
P
D
G
Y
Q
G
S
Q
T
F
H
Site 93
S858
V
P
D
G
Y
Q
G
S
Q
T
F
H
G
A
P
Site 94
T860
D
G
Y
Q
G
S
Q
T
F
H
G
A
P
L
T
Site 95
S874
T
V
A
T
T
G
P
S
V
Y
Y
S
Q
S
P
Site 96
Y876
A
T
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
Site 97
S878
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
N
S
Site 98
S880
P
S
V
Y
Y
S
Q
S
P
A
Y
N
S
Q
Y
Site 99
Y883
Y
Y
S
Q
S
P
A
Y
N
S
Q
Y
L
L
R
Site 100
S885
S
Q
S
P
A
Y
N
S
Q
Y
L
L
R
P
A
Site 101
Y887
S
P
A
Y
N
S
Q
Y
L
L
R
P
A
A
N
Site 102
T896
L
R
P
A
A
N
V
T
P
T
K
G
P
V
Y
Site 103
T898
P
A
A
N
V
T
P
T
K
G
P
V
Y
G
M
Site 104
Y903
T
P
T
K
G
P
V
Y
G
M
N
R
L
P
P
Site 105
Y915
L
P
P
Q
Q
H
I
Y
A
Y
P
Q
Q
M
H
Site 106
T923
A
Y
P
Q
Q
M
H
T
P
P
V
Q
S
S
S
Site 107
S930
T
P
P
V
Q
S
S
S
A
C
M
F
S
Q
E
Site 108
S935
S
S
S
A
C
M
F
S
Q
E
M
Y
G
P
P
Site 109
Y939
C
M
F
S
Q
E
M
Y
G
P
P
A
L
R
F
Site 110
S948
P
P
A
L
R
F
E
S
P
A
T
G
I
L
S
Site 111
T951
L
R
F
E
S
P
A
T
G
I
L
S
P
R
G
Site 112
S955
S
P
A
T
G
I
L
S
P
R
G
D
D
Y
F
Site 113
Y961
L
S
P
R
G
D
D
Y
F
N
Y
N
V
Q
Q
Site 114
Y964
R
G
D
D
Y
F
N
Y
N
V
Q
Q
T
S
T
Site 115
T971
Y
N
V
Q
Q
T
S
T
N
P
P
L
P
E
P
Site 116
Y980
P
P
L
P
E
P
G
Y
F
T
K
P
P
I
A
Site 117
S991
P
P
I
A
A
H
A
S
R
S
A
E
S
K
T
Site 118
T1004
K
T
I
E
F
G
K
T
N
F
V
Q
P
M
P
Site 119
S1018
P
G
E
G
L
R
P
S
L
P
T
Q
A
H
T
Site 120
T1021
G
L
R
P
S
L
P
T
Q
A
H
T
T
Q
P
Site 121
T1025
S
L
P
T
Q
A
H
T
T
Q
P
T
P
F
K
Site 122
T1029
Q
A
H
T
T
Q
P
T
P
F
K
F
N
S
N
Site 123
S1035
P
T
P
F
K
F
N
S
N
F
K
S
N
D
G
Site 124
T1045
K
S
N
D
G
D
F
T
F
S
S
P
Q
V
V
Site 125
S1048
D
G
D
F
T
F
S
S
P
Q
V
V
T
Q
P
Site 126
T1053
F
S
S
P
Q
V
V
T
Q
P
P
P
A
A
Y
Site 127
S1061
Q
P
P
P
A
A
Y
S
N
S
E
S
L
L
G
Site 128
T1071
E
S
L
L
G
L
L
T
S
D
K
P
L
Q
G
Site 129
S1072
S
L
L
G
L
L
T
S
D
K
P
L
Q
G
D
Site 130
Y1081
K
P
L
Q
G
D
G
Y
S
G
A
K
P
I
P
Site 131
S1082
P
L
Q
G
D
G
Y
S
G
A
K
P
I
P
G
Site 132
T1098
Q
T
I
G
P
R
N
T
F
N
F
G
S
K
N
Site 133
S1103
R
N
T
F
N
F
G
S
K
N
V
S
G
I
S
Site 134
S1107
N
F
G
S
K
N
V
S
G
I
S
F
T
E
N
Site 135
S1110
S
K
N
V
S
G
I
S
F
T
E
N
M
G
S
Site 136
T1112
N
V
S
G
I
S
F
T
E
N
M
G
S
S
Q
Site 137
S1117
S
F
T
E
N
M
G
S
S
Q
Q
K
N
S
G
Site 138
S1118
F
T
E
N
M
G
S
S
Q
Q
K
N
S
G
F
Site 139
S1123
G
S
S
Q
Q
K
N
S
G
F
R
R
S
D
D
Site 140
S1128
K
N
S
G
F
R
R
S
D
D
M
F
T
F
H
Site 141
T1133
R
R
S
D
D
M
F
T
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E
V
E
V
S
S
T
S
E
T
T
P
K
Site 294
T2500
S
E
V
E
V
S
S
T
S
E
T
T
P
K
A
Site 295
S2501
E
V
E
V
S
S
T
S
E
T
T
P
K
A
V
Site 296
T2503
E
V
S
S
T
S
E
T
T
P
K
A
V
V
S
Site 297
T2504
V
S
S
T
S
E
T
T
P
K
A
V
V
S
P
Site 298
S2510
T
T
P
K
A
V
V
S
P
P
K
F
V
F
G
Site 299
S2518
P
P
K
F
V
F
G
S
E
S
V
K
S
I
F
Site 300
S2520
K
F
V
F
G
S
E
S
V
K
S
I
F
S
S
Site 301
S2523
F
G
S
E
S
V
K
S
I
F
S
S
E
K
S
Site 302
S2526
E
S
V
K
S
I
F
S
S
E
K
S
K
P
F
Site 303
S2527
S
V
K
S
I
F
S
S
E
K
S
K
P
F
A
Site 304
S2530
S
I
F
S
S
E
K
S
K
P
F
A
F
G
N
Site 305
S2539
P
F
A
F
G
N
S
S
A
T
G
S
L
F
G
Site 306
S2543
G
N
S
S
A
T
G
S
L
F
G
F
S
F
N
Site 307
S2548
T
G
S
L
F
G
F
S
F
N
A
P
L
K
S
Site 308
S2555
S
F
N
A
P
L
K
S
N
N
S
E
T
S
S
Site 309
S2558
A
P
L
K
S
N
N
S
E
T
S
S
V
A
Q
Site 310
T2560
L
K
S
N
N
S
E
T
S
S
V
A
Q
S
G
Site 311
S2562
S
N
N
S
E
T
S
S
V
A
Q
S
G
S
E
Site 312
S2566
E
T
S
S
V
A
Q
S
G
S
E
S
K
V
E
Site 313
S2568
S
S
V
A
Q
S
G
S
E
S
K
V
E
P
K
Site 314
S2570
V
A
Q
S
G
S
E
S
K
V
E
P
K
K
C
Site 315
S2580
E
P
K
K
C
E
L
S
K
N
S
D
I
E
Q
Site 316
S2583
K
C
E
L
S
K
N
S
D
I
E
Q
S
S
D
Site 317
S2589
N
S
D
I
E
Q
S
S
D
S
K
V
K
N
L
Site 318
S2591
D
I
E
Q
S
S
D
S
K
V
K
N
L
F
A
Site 319
S2599
K
V
K
N
L
F
A
S
F
P
T
E
E
S
S
Site 320
S2605
A
S
F
P
T
E
E
S
S
I
N
Y
T
F
K
Site 321
Y2609
T
E
E
S
S
I
N
Y
T
F
K
T
P
E
K
Site 322
T2610
E
E
S
S
I
N
Y
T
F
K
T
P
E
K
A
Site 323
T2613
S
I
N
Y
T
F
K
T
P
E
K
A
K
E
K
Site 324
S2626
E
K
K
K
P
E
D
S
P
S
D
D
D
V
L
Site 325
S2628
K
K
P
E
D
S
P
S
D
D
D
V
L
I
V
Site 326
Y2636
D
D
D
V
L
I
V
Y
E
L
T
P
T
A
E
Site 327
T2639
V
L
I
V
Y
E
L
T
P
T
A
E
Q
K
A
Site 328
T2656
T
K
L
K
L
P
P
T
F
F
C
Y
K
N
R
Site 329
Y2660
L
P
P
T
F
F
C
Y
K
N
R
P
D
Y
V
Site 330
Y2666
C
Y
K
N
R
P
D
Y
V
S
E
E
E
E
D
Site 331
S2668
K
N
R
P
D
Y
V
S
E
E
E
E
D
D
E
Site 332
T2679
E
D
D
E
D
F
E
T
A
V
K
K
L
N
G
Site 333
Y2689
K
K
L
N
G
K
L
Y
L
D
G
S
E
K
C
Site 334
S2693
G
K
L
Y
L
D
G
S
E
K
C
R
P
L
E
Site 335
T2703
C
R
P
L
E
E
N
T
A
D
N
E
K
E
C
Site 336
T2719
I
V
W
E
K
K
P
T
V
E
E
K
A
K
A
Site 337
T2728
E
E
K
A
K
A
D
T
L
K
L
P
P
T
F
Site 338
T2734
D
T
L
K
L
P
P
T
F
F
C
G
V
C
S
Site 339
S2741
T
F
F
C
G
V
C
S
D
T
D
E
D
N
G
Site 340
T2743
F
C
G
V
C
S
D
T
D
E
D
N
G
N
G
Site 341
S2755
G
N
G
E
D
F
Q
S
E
L
Q
K
V
Q
E
Site 342
S2766
K
V
Q
E
A
Q
K
S
Q
T
E
E
I
T
S
Site 343
S2773
S
Q
T
E
E
I
T
S
T
T
D
S
V
Y
T
Site 344
T2774
Q
T
E
E
I
T
S
T
T
D
S
V
Y
T
G
Site 345
S2777
E
I
T
S
T
T
D
S
V
Y
T
G
G
T
E
Site 346
Y2779
T
S
T
T
D
S
V
Y
T
G
G
T
E
V
M
Site 347
S2789
G
T
E
V
M
V
P
S
F
C
K
S
E
E
P
Site 348
S2793
M
V
P
S
F
C
K
S
E
E
P
D
S
I
T
Site 349
S2798
C
K
S
E
E
P
D
S
I
T
K
S
I
S
S
Site 350
T2800
S
E
E
P
D
S
I
T
K
S
I
S
S
P
S
Site 351
S2802
E
P
D
S
I
T
K
S
I
S
S
P
S
V
S
Site 352
S2804
D
S
I
T
K
S
I
S
S
P
S
V
S
S
E
Site 353
S2805
S
I
T
K
S
I
S
S
P
S
V
S
S
E
T
Site 354
S2807
T
K
S
I
S
S
P
S
V
S
S
E
T
M
D
Site 355
S2809
S
I
S
S
P
S
V
S
S
E
T
M
D
K
P
Site 356
S2820
M
D
K
P
V
D
L
S
T
R
K
E
I
D
T
Site 357
T2827
S
T
R
K
E
I
D
T
D
S
T
S
Q
G
E
Site 358
S2829
R
K
E
I
D
T
D
S
T
S
Q
G
E
S
K
Site 359
S2831
E
I
D
T
D
S
T
S
Q
G
E
S
K
I
V
Site 360
S2835
D
S
T
S
Q
G
E
S
K
I
V
S
F
G
F
Site 361
S2839
Q
G
E
S
K
I
V
S
F
G
F
G
S
S
T
Site 362
S2856
S
F
A
D
L
A
S
S
N
S
G
D
F
A
F
Site 363
S2858
A
D
L
A
S
S
N
S
G
D
F
A
F
G
S
Site 364
S2900
V
G
E
D
E
D
G
S
D
E
E
V
V
H
N
Site 365
T2990
A
N
H
V
I
T
K
T
M
E
L
K
P
L
N
Site 366
S3008
N
A
L
V
W
T
A
S
D
Y
A
D
G
E
A
Site 367
Y3010
L
V
W
T
A
S
D
Y
A
D
G
E
A
K
V
Site 368
T3026
Q
L
A
V
R
F
K
T
K
E
V
A
D
C
F
Site 369
S3053
K
L
Q
K
G
H
V
S
L
A
A
E
L
S
K
Site 370
T3128
V
C
Q
G
G
D
I
T
K
H
D
G
T
G
G
Site 371
T3133
D
I
T
K
H
D
G
T
G
G
Q
S
I
Y
G
Site 372
Y3139
G
T
G
G
Q
S
I
Y
G
D
K
F
E
D
E
Site 373
S3159
H
T
G
P
G
L
L
S
M
A
N
Q
G
Q
N
Site 374
S3170
Q
G
Q
N
T
N
N
S
Q
F
V
I
T
L
K
Site 375
T3198
F
V
K
D
G
M
D
T
V
K
K
I
E
S
F
Site 376
S3204
D
T
V
K
K
I
E
S
F
G
S
P
K
G
S
Site 377
S3207
K
K
I
E
S
F
G
S
P
K
G
S
V
C
R
Site 378
S3211
S
F
G
S
P
K
G
S
V
C
R
R
I
T
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation