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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLC-3
Full Name:
H(+)/Cl(-) exchange transporter 3
Alias:
Chloride channel protein 3;Chloride transporter ClC-3
Type:
Mass (Da):
84793
Number AA:
762
UniProt ID:
P51790
International Prot ID:
IPI00749152
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0009986
GO:0031410
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030165
GO:0015297
PhosphoSite+
KinaseNET
Biological Process:
GO:0006821
GO:0048388
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
H(+)/Cl(-) exchange transporter 3 pan-specific antibody AB-NN234-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN234-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
E
Q
L
F
H
R
G
Y
Y
R
N
S
Y
N
S
Site 2
Y12
Q
L
F
H
R
G
Y
Y
R
N
S
Y
N
S
I
Site 3
S15
H
R
G
Y
Y
R
N
S
Y
N
S
I
T
S
A
Site 4
Y16
R
G
Y
Y
R
N
S
Y
N
S
I
T
S
A
S
Site 5
S18
Y
Y
R
N
S
Y
N
S
I
T
S
A
S
S
D
Site 6
S23
Y
N
S
I
T
S
A
S
S
D
E
E
L
L
D
Site 7
S24
N
S
I
T
S
A
S
S
D
E
E
L
L
D
G
Site 8
S41
V
I
M
D
F
Q
T
S
E
D
D
N
L
L
D
Site 9
T51
D
N
L
L
D
G
D
T
A
V
G
T
H
Y
T
Site 10
Y57
D
T
A
V
G
T
H
Y
T
M
T
N
G
G
S
Site 11
T60
V
G
T
H
Y
T
M
T
N
G
G
S
I
N
S
Site 12
S64
Y
T
M
T
N
G
G
S
I
N
S
S
T
H
L
Site 13
S68
N
G
G
S
I
N
S
S
T
H
L
L
D
L
L
Site 14
T69
G
G
S
I
N
S
S
T
H
L
L
D
L
L
D
Site 15
Y85
P
I
P
G
V
G
T
Y
D
D
F
H
T
I
D
Site 16
S109
E
R
H
R
R
I
N
S
K
K
K
E
S
A
W
Site 17
S121
S
A
W
E
M
T
K
S
L
Y
D
A
W
S
G
Site 18
Y123
W
E
M
T
K
S
L
Y
D
A
W
S
G
W
L
Site 19
T180
C
W
G
S
N
E
T
T
F
E
E
R
D
K
C
Site 20
Y303
F
S
Y
L
F
P
K
Y
S
T
N
E
A
K
K
Site 21
S304
S
Y
L
F
P
K
Y
S
T
N
E
A
K
K
R
Site 22
Y343
S
L
E
E
V
S
Y
Y
F
P
L
K
T
L
W
Site 23
Y378
N
S
R
L
V
L
F
Y
V
E
Y
H
T
P
W
Site 24
S420
A
W
C
R
R
R
K
S
T
K
F
G
K
Y
P
Site 25
T421
W
C
R
R
R
K
S
T
K
F
G
K
Y
P
V
Site 26
Y447
V
I
A
F
P
N
P
Y
T
R
L
N
T
S
E
Site 27
T452
N
P
Y
T
R
L
N
T
S
E
L
I
K
E
L
Site 28
S470
C
G
P
L
E
S
S
S
L
C
D
Y
R
N
D
Site 29
Y474
E
S
S
S
L
C
D
Y
R
N
D
M
N
A
S
Site 30
Y630
A
F
G
R
E
G
I
Y
E
A
H
I
R
L
N
Site 31
T651
A
K
E
E
F
T
H
T
T
L
A
A
D
V
M
Site 32
T676
V
L
T
Q
D
N
M
T
V
D
D
I
E
N
M
Site 33
T713
F
A
L
R
R
D
L
T
I
A
I
E
S
A
R
Site 34
S718
D
L
T
I
A
I
E
S
A
R
K
K
Q
E
G
Site 35
S729
K
Q
E
G
I
V
G
S
S
R
V
C
F
A
Q
Site 36
T738
R
V
C
F
A
Q
H
T
P
S
L
P
A
E
S
Site 37
S740
C
F
A
Q
H
T
P
S
L
P
A
E
S
P
R
Site 38
S745
T
P
S
L
P
A
E
S
P
R
P
L
K
L
R
Site 39
S753
P
R
P
L
K
L
R
S
I
L
D
M
S
P
F
Site 40
S758
L
R
S
I
L
D
M
S
P
F
T
V
T
D
H
Site 41
T796
G
R
L
L
G
I
I
T
K
K
D
I
L
R
H
Site 42
T807
I
L
R
H
M
A
Q
T
A
N
Q
D
P
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation