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Updated November 2019
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Protein Info
Short Name:
Myomesin 1
Full Name:
Myomesin-1
Alias:
190 kDa connectin- associated protein; 190 kDa titin-associated protein; MYM1; MYOM1; Myomesin 1, 185kDa; Skelemin; Titin-associated 190 kDa protein
Type:
Cytoskeletal protein
Mass (Da):
187627
Number AA:
1685
UniProt ID:
P52179
International Prot ID:
IPI00479390
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005863
Uniprot
OncoNet
Molecular Function:
GO:0008307
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
Y
Q
R
C
H
Q
H
Y
D
L
S
Y
R
N
K
Site 2
Y17
H
Q
H
Y
D
L
S
Y
R
N
K
D
V
R
S
Site 3
S24
Y
R
N
K
D
V
R
S
T
V
S
H
Y
Q
R
Site 4
T25
R
N
K
D
V
R
S
T
V
S
H
Y
Q
R
E
Site 5
Y29
V
R
S
T
V
S
H
Y
Q
R
E
K
K
R
S
Site 6
S36
Y
Q
R
E
K
K
R
S
A
V
Y
T
Q
G
S
Site 7
Y39
E
K
K
R
S
A
V
Y
T
Q
G
S
T
A
Y
Site 8
T40
K
K
R
S
A
V
Y
T
Q
G
S
T
A
Y
S
Site 9
S43
S
A
V
Y
T
Q
G
S
T
A
Y
S
S
R
S
Site 10
T44
A
V
Y
T
Q
G
S
T
A
Y
S
S
R
S
S
Site 11
Y46
Y
T
Q
G
S
T
A
Y
S
S
R
S
S
A
A
Site 12
S47
T
Q
G
S
T
A
Y
S
S
R
S
S
A
A
H
Site 13
S48
Q
G
S
T
A
Y
S
S
R
S
S
A
A
H
R
Site 14
S51
T
A
Y
S
S
R
S
S
A
A
H
R
R
E
S
Site 15
S58
S
A
A
H
R
R
E
S
E
A
F
R
R
A
S
Site 16
S65
S
E
A
F
R
R
A
S
A
S
S
S
Q
Q
Q
Site 17
S67
A
F
R
R
A
S
A
S
S
S
Q
Q
Q
A
S
Site 18
S68
F
R
R
A
S
A
S
S
S
Q
Q
Q
A
S
Q
Site 19
S69
R
R
A
S
A
S
S
S
Q
Q
Q
A
S
Q
H
Site 20
S74
S
S
S
Q
Q
Q
A
S
Q
H
A
L
S
S
E
Site 21
S79
Q
A
S
Q
H
A
L
S
S
E
V
S
R
K
A
Site 22
S80
A
S
Q
H
A
L
S
S
E
V
S
R
K
A
A
Site 23
S83
H
A
L
S
S
E
V
S
R
K
A
A
S
A
Y
Site 24
S88
E
V
S
R
K
A
A
S
A
Y
D
Y
G
S
S
Site 25
Y90
S
R
K
A
A
S
A
Y
D
Y
G
S
S
H
G
Site 26
Y92
K
A
A
S
A
Y
D
Y
G
S
S
H
G
L
T
Site 27
S94
A
S
A
Y
D
Y
G
S
S
H
G
L
T
D
S
Site 28
S95
S
A
Y
D
Y
G
S
S
H
G
L
T
D
S
S
Site 29
T99
Y
G
S
S
H
G
L
T
D
S
S
L
L
L
D
Site 30
S101
S
S
H
G
L
T
D
S
S
L
L
L
D
D
Y
Site 31
S102
S
H
G
L
T
D
S
S
L
L
L
D
D
Y
S
Site 32
Y108
S
S
L
L
L
D
D
Y
S
S
K
L
S
P
K
Site 33
S109
S
L
L
L
D
D
Y
S
S
K
L
S
P
K
P
Site 34
S110
L
L
L
D
D
Y
S
S
K
L
S
P
K
P
K
Site 35
S113
D
D
Y
S
S
K
L
S
P
K
P
K
R
A
K
Site 36
S122
K
P
K
R
A
K
H
S
L
L
S
G
E
E
K
Site 37
S125
R
A
K
H
S
L
L
S
G
E
E
K
E
N
L
Site 38
S134
E
E
K
E
N
L
P
S
D
Y
M
V
P
I
F
Site 39
Y136
K
E
N
L
P
S
D
Y
M
V
P
I
F
S
G
Site 40
S142
D
Y
M
V
P
I
F
S
G
R
Q
K
H
V
S
Site 41
S149
S
G
R
Q
K
H
V
S
G
I
T
D
T
E
E
Site 42
Y165
R
I
K
E
A
A
A
Y
I
A
Q
R
N
L
L
Site 43
S174
A
Q
R
N
L
L
A
S
E
E
G
I
T
T
S
Site 44
T179
L
A
S
E
E
G
I
T
T
S
K
Q
S
T
A
Site 45
T180
A
S
E
E
G
I
T
T
S
K
Q
S
T
A
S
Site 46
S181
S
E
E
G
I
T
T
S
K
Q
S
T
A
S
K
Site 47
S184
G
I
T
T
S
K
Q
S
T
A
S
K
Q
T
T
Site 48
T185
I
T
T
S
K
Q
S
T
A
S
K
Q
T
T
A
Site 49
T191
S
T
A
S
K
Q
T
T
A
S
K
Q
S
T
A
Site 50
S193
A
S
K
Q
T
T
A
S
K
Q
S
T
A
S
K
Site 51
S196
Q
T
T
A
S
K
Q
S
T
A
S
K
Q
S
T
Site 52
T197
T
T
A
S
K
Q
S
T
A
S
K
Q
S
T
A
Site 53
S199
A
S
K
Q
S
T
A
S
K
Q
S
T
A
S
K
Site 54
T203
S
T
A
S
K
Q
S
T
A
S
K
Q
S
T
A
Site 55
S205
A
S
K
Q
S
T
A
S
K
Q
S
T
A
S
R
Site 56
T209
S
T
A
S
K
Q
S
T
A
S
R
Q
S
T
A
Site 57
S211
A
S
K
Q
S
T
A
S
R
Q
S
T
A
S
R
Site 58
S214
Q
S
T
A
S
R
Q
S
T
A
S
R
Q
S
V
Site 59
T215
S
T
A
S
R
Q
S
T
A
S
R
Q
S
V
V
Site 60
S217
A
S
R
Q
S
T
A
S
R
Q
S
V
V
S
K
Site 61
S220
Q
S
T
A
S
R
Q
S
V
V
S
K
Q
A
T
Site 62
S223
A
S
R
Q
S
V
V
S
K
Q
A
T
S
A
L
Site 63
T235
S
A
L
Q
Q
E
E
T
S
E
K
K
S
R
K
Site 64
S240
E
E
T
S
E
K
K
S
R
K
V
V
I
R
E
Site 65
S253
R
E
K
A
E
R
L
S
L
R
K
T
L
E
E
Site 66
T257
E
R
L
S
L
R
K
T
L
E
E
T
E
T
Y
Site 67
T263
K
T
L
E
E
T
E
T
Y
H
A
K
L
N
E
Site 68
Y264
T
L
E
E
T
E
T
Y
H
A
K
L
N
E
D
Site 69
S285
E
F
I
I
K
P
R
S
H
T
V
W
E
K
E
Site 70
T287
I
I
K
P
R
S
H
T
V
W
E
K
E
N
V
Site 71
Y311
P
E
P
R
V
T
W
Y
K
N
Q
V
P
I
N
Site 72
Y326
V
H
A
N
P
G
K
Y
I
I
E
S
R
Y
G
Site 73
T336
E
S
R
Y
G
M
H
T
L
E
I
N
G
C
D
Site 74
S353
D
T
A
Q
Y
R
A
S
A
M
N
V
K
G
E
Site 75
S366
G
E
L
S
A
Y
A
S
V
V
V
K
R
Y
K
Site 76
T379
Y
K
G
E
F
D
E
T
R
F
H
A
G
A
S
Site 77
S386
T
R
F
H
A
G
A
S
T
M
P
L
S
F
G
Site 78
T395
M
P
L
S
F
G
V
T
P
Y
G
Y
A
S
R
Site 79
Y397
L
S
F
G
V
T
P
Y
G
Y
A
S
R
F
E
Site 80
Y399
F
G
V
T
P
Y
G
Y
A
S
R
F
E
I
H
Site 81
S414
F
D
D
K
F
D
V
S
F
G
R
E
G
E
T
Site 82
Y444
F
Q
P
E
I
Q
W
Y
R
N
G
V
P
L
S
Site 83
S451
Y
R
N
G
V
P
L
S
P
S
K
W
V
Q
T
Site 84
S453
N
G
V
P
L
S
P
S
K
W
V
Q
T
L
W
Site 85
T466
L
W
S
G
E
R
A
T
L
T
F
S
H
L
N
Site 86
T468
S
G
E
R
A
T
L
T
F
S
H
L
N
K
E
Site 87
Y480
N
K
E
D
E
G
L
Y
T
I
R
V
R
M
G
Site 88
T481
K
E
D
E
G
L
Y
T
I
R
V
R
M
G
E
Site 89
Y489
I
R
V
R
M
G
E
Y
Y
E
Q
Y
S
A
Y
Site 90
Y490
R
V
R
M
G
E
Y
Y
E
Q
Y
S
A
Y
V
Site 91
Y493
M
G
E
Y
Y
E
Q
Y
S
A
Y
V
F
V
R
Site 92
Y496
Y
Y
E
Q
Y
S
A
Y
V
F
V
R
D
A
D
Site 93
Y525
C
L
E
A
N
K
D
Y
I
I
I
S
W
K
Q
Site 94
S557
E
V
G
T
D
S
W
S
Q
C
N
D
T
P
V
Site 95
T562
S
W
S
Q
C
N
D
T
P
V
K
F
A
R
F
Site 96
S579
T
G
L
I
E
G
R
S
Y
I
F
R
V
R
A
Site 97
S596
K
M
G
I
G
F
P
S
R
V
S
E
P
V
A
Site 98
S615
A
E
K
A
R
L
K
S
R
P
S
A
P
W
T
Site 99
S618
A
R
L
K
S
R
P
S
A
P
W
T
G
Q
I
Site 100
T622
S
R
P
S
A
P
W
T
G
Q
I
I
V
T
E
Site 101
S633
I
V
T
E
E
E
P
S
E
G
I
V
P
G
P
Site 102
S645
P
G
P
P
T
D
L
S
V
T
E
A
T
R
S
Site 103
T647
P
P
T
D
L
S
V
T
E
A
T
R
S
Y
V
Site 104
S652
S
V
T
E
A
T
R
S
Y
V
V
L
S
W
K
Site 105
Y653
V
T
E
A
T
R
S
Y
V
V
L
S
W
K
P
Site 106
S657
T
R
S
Y
V
V
L
S
W
K
P
P
G
Q
R
Site 107
Y671
R
G
H
E
G
I
M
Y
F
V
E
K
C
E
A
Site 108
T688
E
N
W
Q
R
V
N
T
E
L
P
V
K
S
P
Site 109
S694
N
T
E
L
P
V
K
S
P
R
F
A
L
F
D
Site 110
Y708
D
L
A
E
G
K
S
Y
C
F
R
V
R
C
S
Site 111
S715
Y
C
F
R
V
R
C
S
N
S
A
G
V
G
E
Site 112
S717
F
R
V
R
C
S
N
S
A
G
V
G
E
P
S
Site 113
T730
P
S
E
A
T
E
V
T
V
V
G
D
K
L
D
Site 114
T751
K
I
I
P
S
R
N
T
D
T
S
V
V
V
S
Site 115
T753
I
P
S
R
N
T
D
T
S
V
V
V
S
W
E
Site 116
S754
P
S
R
N
T
D
T
S
V
V
V
S
W
E
E
Site 117
S758
T
D
T
S
V
V
V
S
W
E
E
S
K
D
A
Site 118
S762
V
V
V
S
W
E
E
S
K
D
A
K
E
L
V
Site 119
S780
I
E
A
S
V
A
G
S
G
K
W
E
P
C
N
Site 120
T797
P
V
K
G
S
R
F
T
C
H
G
L
V
T
G
Site 121
S820
A
V
N
A
A
G
L
S
E
Y
S
Q
D
S
E
Site 122
S826
L
S
E
Y
S
Q
D
S
E
A
I
E
V
K
A
Site 123
S848
P
D
V
C
P
A
L
S
D
E
P
G
G
L
T
Site 124
T855
S
D
E
P
G
G
L
T
A
S
R
G
R
V
H
Site 125
S857
E
P
G
G
L
T
A
S
R
G
R
V
H
E
A
Site 126
S865
R
G
R
V
H
E
A
S
P
P
T
F
Q
K
D
Site 127
T868
V
H
E
A
S
P
P
T
F
Q
K
D
A
L
L
Site 128
S877
Q
K
D
A
L
L
G
S
K
P
N
K
P
S
L
Site 129
S883
G
S
K
P
N
K
P
S
L
P
S
S
S
Q
N
Site 130
S886
P
N
K
P
S
L
P
S
S
S
Q
N
L
G
Q
Site 131
S887
N
K
P
S
L
P
S
S
S
Q
N
L
G
Q
T
Site 132
S888
K
P
S
L
P
S
S
S
Q
N
L
G
Q
T
E
Site 133
T902
E
V
S
K
V
S
E
T
V
Q
E
E
L
T
P
Site 134
T908
E
T
V
Q
E
E
L
T
P
P
P
Q
K
A
A
Site 135
S920
K
A
A
P
Q
G
K
S
K
S
D
P
L
K
K
Site 136
S922
A
P
Q
G
K
S
K
S
D
P
L
K
K
K
T
Site 137
T929
S
D
P
L
K
K
K
T
D
R
A
P
P
S
P
Site 138
S935
K
T
D
R
A
P
P
S
P
P
C
D
I
T
C
Site 139
T941
P
S
P
P
C
D
I
T
C
L
E
S
F
R
D
Site 140
S949
C
L
E
S
F
R
D
S
M
V
L
G
W
K
Q
Site 141
Y968
G
G
A
E
I
T
G
Y
Y
V
N
Y
R
E
V
Site 142
Y969
G
A
E
I
T
G
Y
Y
V
N
Y
R
E
V
I
Site 143
Y996
K
A
V
S
E
E
A
Y
K
I
S
N
L
K
E
Site 144
Y1007
N
L
K
E
N
M
V
Y
Q
F
Q
V
A
A
M
Site 145
S1044
A
V
P
G
P
P
H
S
L
K
C
S
E
V
R
Site 146
S1048
P
P
H
S
L
K
C
S
E
V
R
K
D
S
L
Site 147
S1054
C
S
E
V
R
K
D
S
L
V
L
Q
W
K
P
Site 148
S1065
Q
W
K
P
P
V
H
S
G
R
T
P
V
T
G
Site 149
T1068
P
P
V
H
S
G
R
T
P
V
T
G
Y
F
V
Site 150
Y1073
G
R
T
P
V
T
G
Y
F
V
D
L
K
E
A
Site 151
Y1099
E
A
A
I
K
N
V
Y
L
K
V
R
G
L
K
Site 152
S1110
R
G
L
K
E
G
V
S
Y
V
F
R
V
R
A
Site 153
T1141
V
A
E
T
R
P
G
T
K
E
V
V
V
N
V
Site 154
S1155
V
D
D
D
G
V
I
S
L
N
F
E
C
D
K
Site 155
T1164
N
F
E
C
D
K
M
T
P
K
S
E
F
S
W
Site 156
S1167
C
D
K
M
T
P
K
S
E
F
S
W
S
K
D
Site 157
S1170
M
T
P
K
S
E
F
S
W
S
K
D
Y
V
S
Site 158
S1172
P
K
S
E
F
S
W
S
K
D
Y
V
S
T
E
Site 159
Y1175
E
F
S
W
S
K
D
Y
V
S
T
E
D
S
P
Site 160
S1177
S
W
S
K
D
Y
V
S
T
E
D
S
P
R
L
Site 161
S1181
D
Y
V
S
T
E
D
S
P
R
L
E
V
E
S
Site 162
S1188
S
P
R
L
E
V
E
S
K
G
N
K
T
K
M
Site 163
T1196
K
G
N
K
T
K
M
T
F
K
D
L
G
M
D
Site 164
Y1208
G
M
D
D
L
G
I
Y
S
C
D
V
T
D
T
Site 165
T1213
G
I
Y
S
C
D
V
T
D
T
D
G
I
A
S
Site 166
T1215
Y
S
C
D
V
T
D
T
D
G
I
A
S
S
Y
Site 167
Y1222
T
D
G
I
A
S
S
Y
L
I
D
E
E
E
L
Site 168
S1236
L
K
R
L
L
A
L
S
H
E
H
K
F
P
T
Site 169
T1243
S
H
E
H
K
F
P
T
V
P
V
K
S
E
L
Site 170
Y1277
S
G
N
A
K
V
N
Y
I
F
N
E
K
E
I
Site 171
Y1290
E
I
F
E
G
P
K
Y
K
M
H
I
D
R
N
Site 172
T1315
L
Q
D
E
D
E
G
T
Y
T
F
Q
L
Q
D
Site 173
T1317
D
E
D
E
G
T
Y
T
F
Q
L
Q
D
G
K
Site 174
S1329
D
G
K
A
T
N
H
S
T
V
V
L
V
G
D
Site 175
Y1363
Q
G
P
H
F
V
E
Y
L
S
W
E
V
T
G
Site 176
Y1392
K
E
T
H
I
V
W
Y
K
D
E
R
E
I
S
Site 177
S1399
Y
K
D
E
R
E
I
S
V
D
E
K
H
D
F
Site 178
Y1426
S
K
K
D
A
G
I
Y
E
V
I
L
K
D
D
Site 179
S1439
D
D
R
G
K
D
K
S
R
L
K
L
V
D
E
Site 180
T1471
T
D
L
K
I
Q
S
T
A
E
G
I
Q
L
Y
Site 181
S1493
E
D
L
K
V
N
W
S
H
N
G
S
A
I
R
Site 182
S1497
V
N
W
S
H
N
G
S
A
I
R
Y
S
D
R
Site 183
Y1501
H
N
G
S
A
I
R
Y
S
D
R
V
K
T
G
Site 184
S1502
N
G
S
A
I
R
Y
S
D
R
V
K
T
G
V
Site 185
T1507
R
Y
S
D
R
V
K
T
G
V
T
G
E
Q
I
Site 186
T1522
W
L
Q
I
N
E
P
T
P
N
D
K
G
K
Y
Site 187
Y1529
T
P
N
D
K
G
K
Y
V
M
E
L
F
D
G
Site 188
T1538
M
E
L
F
D
G
K
T
G
H
Q
K
T
V
D
Site 189
T1543
G
K
T
G
H
Q
K
T
V
D
L
S
G
Q
A
Site 190
Y1551
V
D
L
S
G
Q
A
Y
D
E
A
Y
A
E
F
Site 191
Y1555
G
Q
A
Y
D
E
A
Y
A
E
F
Q
R
L
K
Site 192
T1593
E
G
K
A
L
N
L
T
C
N
V
W
G
D
P
Site 193
S1605
G
D
P
P
P
E
V
S
W
L
K
N
E
K
A
Site 194
S1615
K
N
E
K
A
L
A
S
D
D
H
C
N
L
K
Site 195
S1637
Y
F
T
I
N
G
V
S
T
A
D
S
G
K
Y
Site 196
Y1644
S
T
A
D
S
G
K
Y
G
L
V
V
K
N
K
Site 197
Y1652
G
L
V
V
K
N
K
Y
G
S
E
T
S
D
F
Site 198
S1657
N
K
Y
G
S
E
T
S
D
F
T
V
S
V
F
Site 199
T1660
G
S
E
T
S
D
F
T
V
S
V
F
I
P
E
Site 200
S1662
E
T
S
D
F
T
V
S
V
F
I
P
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation