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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIF11
Full Name:
Kinesin-like protein KIF11
Alias:
Eg5; HKSP; KIFL1; Kinesin family member 11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related mitotic motor protein; Kinesin-related motor protein Eg5; KNSL1; Thyroid receptor interacting protein 5; TRIP5; TRIP-5
Type:
Microtubule binding protein; Motor protein
Mass (Da):
119159
Number AA:
1056
UniProt ID:
P52732
International Prot ID:
IPI00305289
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016585
GO:0005871
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007018
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
Q
P
N
S
S
A
K
Site 2
S7
_
M
A
S
Q
P
N
S
S
A
K
K
K
E
E
Site 3
S36
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
Site 4
S51
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
Site 5
S61
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
Site 6
S62
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
Site 7
T65
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
Site 8
Y66
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
Site 9
T67
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
Site 10
Y104
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
Site 11
T112
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
Site 12
T114
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
Site 13
S120
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
Site 14
Y125
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
Site 15
T126
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
Site 16
T152
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
Site 17
S155
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
Site 18
S159
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
Site 19
S175
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Site 20
S176
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
Site 21
S179
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
Site 22
T203
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Site 23
Y211
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
Site 24
T223
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Site 25
T226
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
Site 26
Y231
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
Site 27
S232
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
Site 28
S233
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
Site 29
S235
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
Site 30
S237
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
Site 31
S240
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
Site 32
S269
N
L
V
D
L
A
G
S
E
N
I
G
R
S
G
Site 33
S291
E
A
G
N
I
N
Q
S
L
L
T
L
G
R
V
Site 34
T294
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
Site 35
T306
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
Site 36
S314
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
Site 37
T317
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
Site 38
S323
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
Site 39
T346
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
Site 40
S348
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
Site 41
T349
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
Site 42
Y352
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
Site 43
Y399
A
R
E
K
N
G
V
Y
I
S
E
E
N
F
R
Site 44
S401
E
K
N
G
V
Y
I
S
E
E
N
F
R
V
M
Site 45
S409
E
E
N
F
R
V
M
S
G
K
L
T
V
Q
E
Site 46
T413
R
V
M
S
G
K
L
T
V
Q
E
E
Q
I
V
Site 47
T437
E
E
E
L
N
R
V
T
E
L
F
M
D
N
K
Site 48
S452
N
E
L
D
Q
C
K
S
D
L
Q
N
K
T
Q
Site 49
T458
K
S
D
L
Q
N
K
T
Q
E
L
E
T
T
Q
Site 50
T463
N
K
T
Q
E
L
E
T
T
Q
K
H
L
Q
E
Site 51
T464
K
T
Q
E
L
E
T
T
Q
K
H
L
Q
E
T
Site 52
Y480
L
Q
L
V
K
E
E
Y
I
T
S
A
L
E
S
Site 53
T482
L
V
K
E
E
Y
I
T
S
A
L
E
S
T
E
Site 54
S483
V
K
E
E
Y
I
T
S
A
L
E
S
T
E
E
Site 55
S487
Y
I
T
S
A
L
E
S
T
E
E
K
L
H
D
Site 56
T502
A
A
S
K
L
L
N
T
V
E
E
T
T
K
D
Site 57
T506
L
L
N
T
V
E
E
T
T
K
D
V
S
G
L
Site 58
T507
L
N
T
V
E
E
T
T
K
D
V
S
G
L
H
Site 59
S511
E
E
T
T
K
D
V
S
G
L
H
S
K
L
D
Site 60
S515
K
D
V
S
G
L
H
S
K
L
D
R
K
K
A
Site 61
S553
E
E
L
I
K
D
G
S
S
K
Q
K
A
M
L
Site 62
S597
T
S
I
P
E
N
V
S
T
H
V
S
Q
I
F
Site 63
T598
S
I
P
E
N
V
S
T
H
V
S
Q
I
F
N
Site 64
S612
N
M
I
L
K
E
Q
S
L
A
A
E
S
K
T
Site 65
T643
L
E
M
I
L
S
P
T
V
V
S
I
L
K
I
Site 66
S652
V
S
I
L
K
I
N
S
Q
L
K
H
I
F
K
Site 67
T663
H
I
F
K
T
S
L
T
V
A
D
K
I
E
D
Site 68
S696
L
Q
E
N
T
I
C
S
L
V
E
S
Q
K
Q
Site 69
S700
T
I
C
S
L
V
E
S
Q
K
Q
C
G
N
L
Site 70
T713
N
L
T
E
D
L
K
T
I
K
Q
T
H
S
Q
Site 71
S719
K
T
I
K
Q
T
H
S
Q
E
L
C
K
L
M
Site 72
S748
E
N
I
Q
K
P
L
S
S
V
Q
E
N
I
Q
Site 73
S776
S
Q
K
F
C
A
D
S
D
G
F
S
Q
E
L
Site 74
S780
C
A
D
S
D
G
F
S
Q
E
L
R
N
F
N
Site 75
S797
G
T
K
L
V
E
E
S
V
K
H
S
D
K
L
Site 76
S801
V
E
E
S
V
K
H
S
D
K
L
N
G
N
L
Site 77
S812
N
G
N
L
E
K
I
S
Q
E
T
E
Q
R
C
Site 78
S821
E
T
E
Q
R
C
E
S
L
N
T
R
T
V
Y
Site 79
T824
Q
R
C
E
S
L
N
T
R
T
V
Y
F
S
E
Site 80
Y828
S
L
N
T
R
T
V
Y
F
S
E
Q
W
V
S
Site 81
S830
N
T
R
T
V
Y
F
S
E
Q
W
V
S
S
L
Site 82
S835
Y
F
S
E
Q
W
V
S
S
L
N
E
R
E
Q
Site 83
S836
F
S
E
Q
W
V
S
S
L
N
E
R
E
Q
E
Site 84
S858
V
S
Q
C
C
E
A
S
S
S
D
I
T
E
K
Site 85
S860
Q
C
C
E
A
S
S
S
D
I
T
E
K
S
D
Site 86
T863
E
A
S
S
S
D
I
T
E
K
S
D
G
R
K
Site 87
S866
S
S
D
I
T
E
K
S
D
G
R
K
A
A
H
Site 88
T901
Q
N
L
E
L
N
E
T
I
K
I
G
L
T
K
Site 89
T923
D
L
K
L
D
I
P
T
G
T
T
P
Q
R
K
Site 90
T925
K
L
D
I
P
T
G
T
T
P
Q
R
K
S
Y
Site 91
T926
L
D
I
P
T
G
T
T
P
Q
R
K
S
Y
L
Site 92
S931
G
T
T
P
Q
R
K
S
Y
L
Y
P
S
T
L
Site 93
Y932
T
T
P
Q
R
K
S
Y
L
Y
P
S
T
L
V
Site 94
Y934
P
Q
R
K
S
Y
L
Y
P
S
T
L
V
R
T
Site 95
S936
R
K
S
Y
L
Y
P
S
T
L
V
R
T
E
P
Site 96
T937
K
S
Y
L
Y
P
S
T
L
V
R
T
E
P
R
Site 97
T941
Y
P
S
T
L
V
R
T
E
P
R
E
H
L
L
Site 98
T987
E
A
V
L
G
Q
Y
T
E
E
P
L
S
Q
E
Site 99
S992
Q
Y
T
E
E
P
L
S
Q
E
P
S
V
D
A
Site 100
S996
E
P
L
S
Q
E
P
S
V
D
A
G
V
D
C
Site 101
S1017
P
F
F
Q
H
K
K
S
H
G
K
D
K
E
N
Site 102
T1029
K
E
N
R
G
I
N
T
L
E
R
S
K
V
E
Site 103
S1033
G
I
N
T
L
E
R
S
K
V
E
E
T
T
E
Site 104
T1044
E
T
T
E
H
L
V
T
K
S
R
L
P
L
R
Site 105
S1046
T
E
H
L
V
T
K
S
R
L
P
L
R
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation