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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP3
Full Name:
Beta-chimaerin
Alias:
BCH; CHIO; CHN2; RHOGAP3; Rho-GTPase-activating 3
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
53924
Number AA:
468
UniProt ID:
P52757
International Prot ID:
IPI00428671
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005070
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
A
S
S
N
S
S
L
S
G
S
Site 2
S7
_
M
A
A
S
S
N
S
S
L
S
G
S
S
V
Site 3
S8
M
A
A
S
S
N
S
S
L
S
G
S
S
V
S
Site 4
S10
A
S
S
N
S
S
L
S
G
S
S
V
S
S
D
Site 5
S12
S
N
S
S
L
S
G
S
S
V
S
S
D
A
E
Site 6
S13
N
S
S
L
S
G
S
S
V
S
S
D
A
E
E
Site 7
S16
L
S
G
S
S
V
S
S
D
A
E
E
Y
Q
P
Site 8
Y21
V
S
S
D
A
E
E
Y
Q
P
P
I
W
K
S
Site 9
Y31
P
I
W
K
S
Y
L
Y
Q
L
Q
Q
E
A
P
Site 10
Y55
E
V
E
N
R
P
K
Y
Y
G
R
E
F
H
G
Site 11
Y56
V
E
N
R
P
K
Y
Y
G
R
E
F
H
G
I
Site 12
Y80
L
G
G
V
E
G
A
Y
I
L
R
E
S
Q
R
Site 13
S85
G
A
Y
I
L
R
E
S
Q
R
Q
P
G
C
Y
Site 14
Y92
S
Q
R
Q
P
G
C
Y
T
L
A
L
R
F
G
Site 15
T102
A
L
R
F
G
N
Q
T
L
N
Y
R
L
F
H
Site 16
Y105
F
G
N
Q
T
L
N
Y
R
L
F
H
D
G
K
Site 17
S122
V
G
E
K
R
F
E
S
I
H
D
L
V
T
D
Site 18
Y153
K
M
T
T
N
P
I
Y
E
H
I
G
Y
A
T
Site 19
Y158
P
I
Y
E
H
I
G
Y
A
T
L
L
R
E
K
Site 20
T160
Y
E
H
I
G
Y
A
T
L
L
R
E
K
V
S
Site 21
S167
T
L
L
R
E
K
V
S
R
R
L
S
R
S
K
Site 22
S171
E
K
V
S
R
R
L
S
R
S
K
N
E
P
R
Site 23
S173
V
S
R
R
L
S
R
S
K
N
E
P
R
K
T
Site 24
T180
S
K
N
E
P
R
K
T
N
V
T
H
E
E
H
Site 25
T183
E
P
R
K
T
N
V
T
H
E
E
H
T
A
V
Site 26
S194
H
T
A
V
E
K
I
S
S
L
V
R
R
A
A
Site 27
T203
L
V
R
R
A
A
L
T
H
N
D
N
H
F
N
Site 28
T288
T
L
V
K
A
H
N
T
Q
R
P
M
V
V
D
Site 29
Y312
G
L
K
S
E
G
L
Y
R
V
S
G
F
T
E
Site 30
S315
S
E
G
L
Y
R
V
S
G
F
T
E
H
I
E
Site 31
S338
D
G
E
K
A
D
I
S
A
N
V
Y
P
D
I
Site 32
T402
L
P
P
A
H
Y
E
T
L
R
Y
L
M
I
H
Site 33
Y405
A
H
Y
E
T
L
R
Y
L
M
I
H
L
K
K
Site 34
S442
L
M
R
P
P
E
D
S
T
L
T
T
L
H
D
Site 35
T446
P
E
D
S
T
L
T
T
L
H
D
M
R
Y
Q
Site 36
Y452
T
T
L
H
D
M
R
Y
Q
K
L
I
V
Q
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation