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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Plk1
Full Name:
Serine/threonine-protein kinase PLK1
Alias:
ADRB2; EC 2.7.11.21; Kinase PLK1; PLK; PLK-1; Polo-like kinase 1; Serine- threonine protein kinase 13; STPK13
Type:
EC 2.7.11.21; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family
Mass (Da):
68255
Number AA:
603
UniProt ID:
P53350
International Prot ID:
IPI00021248
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042801
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0051437
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Polo-like protein-serine kinase 1 pan-specific antibody AB-NK145-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK145-2#Polo-like protein-serine kinase 1 T210 phosphosite-specific antibody AB-PK778#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK778#Polo-like protein-serine kinase 1 Y217 phosphosite-specific antibody AB-PK779#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK779#Plktide KinSub - Plk protein kinase substrate peptide - Powder PE-01ADM95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADM95#Polo-like protein-serine kinase 1 (A37-R55, human) peptide - Powder PE-01BEZ85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEZ85#Plk1Subtide - Plk1 (Plk) protein kinase substrate peptide - Powder PE-01BIY85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIY85#Polo-like protein-serine kinase 1 (T214-P220, human) pY217 phosphopeptide - Powder PE-04AKY95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AKY95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
A
A
V
T
A
G
K
Site 2
T6
_
_
M
S
A
A
V
T
A
G
K
L
A
R
A
Site 3
S49
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
Site 4
Y53
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
Site 5
S71
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
Site 6
T75
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
Site 7
S87
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
Site 8
S99
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
Site 9
S103
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Site 10
S137
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
Site 11
T149
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
Site 12
Y155
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
Site 13
Y156
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
Site 14
T210
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
Polo-like protein-serine kinase 1 T210 phosphosite-specific antibody AB-PK778#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK778
Site 15
T214
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
Site 16
Y217
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
Polo-like protein-serine kinase 1 Y217 phosphosite-specific antibody AB-PK779#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK779#Polo-like protein-serine kinase 1 (T214-P220, human) pY217 phosphopeptide - Powder PE-04AKY95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AKY95
Site 17
S224
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
Site 18
S229
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
Site 19
S254
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
Site 20
Y260
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Site 21
Y268
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
Site 22
S269
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
Site 23
T291
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
Site 24
T295
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
Site 25
S307
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
Site 26
Y309
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
Site 27
S326
L
T
I
P
P
R
F
S
I
A
P
S
S
L
D
Site 28
S330
P
R
F
S
I
A
P
S
S
L
D
P
S
N
R
Site 29
S331
R
F
S
I
A
P
S
S
L
D
P
S
N
R
K
Site 30
S335
A
P
S
S
L
D
P
S
N
R
K
P
L
T
V
Site 31
T341
P
S
N
R
K
P
L
T
V
L
N
K
G
L
E
Site 32
T366
E
E
P
V
V
R
E
T
G
E
V
V
D
C
H
Site 33
S375
E
V
V
D
C
H
L
S
D
M
L
Q
Q
L
H
Site 34
S383
D
M
L
Q
Q
L
H
S
V
N
A
S
K
P
S
Site 35
S387
Q
L
H
S
V
N
A
S
K
P
S
E
R
G
L
Site 36
S390
S
V
N
A
S
K
P
S
E
R
G
L
V
R
Q
Site 37
Y417
W
V
S
K
W
V
D
Y
S
D
K
Y
G
L
G
Site 38
Y421
W
V
D
Y
S
D
K
Y
G
L
G
Y
Q
L
C
Site 39
Y425
S
D
K
Y
G
L
G
Y
Q
L
C
D
N
S
V
Site 40
T440
G
V
L
F
N
D
S
T
R
L
I
L
Y
N
D
Site 41
Y445
D
S
T
R
L
I
L
Y
N
D
G
D
S
L
Q
Site 42
S450
I
L
Y
N
D
G
D
S
L
Q
Y
I
E
R
D
Site 43
Y453
N
D
G
D
S
L
Q
Y
I
E
R
D
G
T
E
Site 44
T459
Q
Y
I
E
R
D
G
T
E
S
Y
L
T
V
S
Site 45
S461
I
E
R
D
G
T
E
S
Y
L
T
V
S
S
H
Site 46
Y462
E
R
D
G
T
E
S
Y
L
T
V
S
S
H
P
Site 47
T464
D
G
T
E
S
Y
L
T
V
S
S
H
P
N
S
Site 48
S466
T
E
S
Y
L
T
V
S
S
H
P
N
S
L
M
Site 49
S467
E
S
Y
L
T
V
S
S
H
P
N
S
L
M
K
Site 50
S471
T
V
S
S
H
P
N
S
L
M
K
K
I
T
L
Site 51
Y481
K
K
I
T
L
L
K
Y
F
R
N
Y
M
S
E
Site 52
Y485
L
L
K
Y
F
R
N
Y
M
S
E
H
L
L
K
Site 53
S487
K
Y
F
R
N
Y
M
S
E
H
L
L
K
A
G
Site 54
T498
L
K
A
G
A
N
I
T
P
R
E
G
D
E
L
Site 55
Y510
D
E
L
A
R
L
P
Y
L
R
T
W
F
R
T
Site 56
T513
A
R
L
P
Y
L
R
T
W
F
R
T
R
S
A
Site 57
S519
R
T
W
F
R
T
R
S
A
I
I
L
H
L
S
Site 58
T561
D
E
K
R
D
F
R
T
Y
R
L
S
L
L
E
Site 59
Y562
E
K
R
D
F
R
T
Y
R
L
S
L
L
E
E
Site 60
S565
D
F
R
T
Y
R
L
S
L
L
E
E
Y
G
C
Site 61
Y570
R
L
S
L
L
E
E
Y
G
C
C
K
E
L
A
Site 62
Y582
E
L
A
S
R
L
R
Y
A
R
T
M
V
D
K
Site 63
T585
S
R
L
R
Y
A
R
T
M
V
D
K
L
L
S
Site 64
S592
T
M
V
D
K
L
L
S
S
R
S
A
S
N
R
Site 65
S593
M
V
D
K
L
L
S
S
R
S
A
S
N
R
L
Site 66
S595
D
K
L
L
S
S
R
S
A
S
N
R
L
K
A
Site 67
S597
L
L
S
S
R
S
A
S
N
R
L
K
A
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation