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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLTCL1
Full Name:
Clathrin heavy chain 2
Alias:
CHC22; Clathrin, heavy chain-like 1; Clathrin, heavy polypeptide-like 1; CLH2; CLH22; CLH-22; CLTCL
Type:
Vesicle protein
Mass (Da):
187030
Number AA:
1640
UniProt ID:
P53675
International Prot ID:
IPI00022881
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030132
GO:0030130
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0006886
GO:0006898
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
P
A
N
I
G
F
S
T
L
T
M
E
S
D
K
Site 2
S67
A
P
I
R
R
P
I
S
A
E
S
A
I
M
N
Site 3
T103
K
S
K
M
K
A
H
T
M
A
E
E
V
I
F
Site 4
Y128
L
V
T
E
T
A
V
Y
H
W
S
M
E
G
D
Site 5
T146
M
K
M
F
D
R
H
T
S
L
V
G
C
Q
V
Site 6
Y156
V
G
C
Q
V
I
H
Y
R
T
D
E
Y
Q
K
Site 7
Y161
I
H
Y
R
T
D
E
Y
Q
K
W
L
L
L
V
Site 8
S171
W
L
L
L
V
G
I
S
A
Q
Q
N
R
V
V
Site 9
S185
V
G
A
M
Q
L
Y
S
V
D
R
K
V
S
Q
Site 10
S191
Y
S
V
D
R
K
V
S
Q
P
I
E
G
H
A
Site 11
T214
E
G
N
A
K
P
A
T
L
F
C
F
A
V
R
Site 12
T224
C
F
A
V
R
N
P
T
G
G
K
L
H
I
I
Site 13
Y285
K
Y
G
Y
L
H
L
Y
D
L
E
S
G
V
C
Site 14
T306
S
A
D
T
I
F
V
T
A
P
H
K
P
T
S
Site 15
S313
T
A
P
H
K
P
T
S
G
I
I
G
V
N
K
Site 16
S326
N
K
K
G
Q
V
L
S
V
C
V
E
E
D
N
Site 17
Y337
E
E
D
N
I
V
N
Y
A
T
N
V
L
Q
N
Site 18
S355
G
L
R
L
A
V
R
S
N
L
A
G
A
E
K
Site 19
S376
N
T
L
F
A
Q
G
S
Y
A
E
A
A
K
V
Site 20
T394
A
P
K
G
I
L
R
T
R
E
T
V
Q
K
F
Site 21
T397
G
I
L
R
T
R
E
T
V
Q
K
F
Q
S
I
Site 22
S408
F
Q
S
I
P
A
Q
S
G
Q
A
S
P
L
L
Site 23
S412
P
A
Q
S
G
Q
A
S
P
L
L
Q
Y
F
G
Site 24
S460
K
E
D
K
L
E
C
S
E
E
L
G
D
L
V
Site 25
S477
T
D
P
M
L
A
L
S
V
Y
L
R
A
N
V
Site 26
Y504
Q
F
Q
K
I
V
L
Y
A
K
K
V
G
Y
T
Site 27
Y510
L
Y
A
K
K
V
G
Y
T
P
D
W
I
F
L
Site 28
S525
L
R
G
V
M
K
I
S
P
E
Q
G
L
Q
F
Site 29
Y608
G
N
K
M
F
T
H
Y
D
R
A
H
I
A
Q
Site 30
Y634
L
E
H
Y
T
D
L
Y
D
I
K
R
A
V
V
Site 31
T643
I
K
R
A
V
V
H
T
H
L
L
N
P
E
W
Site 32
S672
E
C
L
H
A
M
L
S
A
N
I
R
Q
N
L
Site 33
Y689
C
V
Q
V
A
S
K
Y
H
E
Q
L
G
T
Q
Site 34
T695
K
Y
H
E
Q
L
G
T
Q
A
L
V
E
L
F
Site 35
S707
E
L
F
E
S
F
K
S
Y
K
G
L
F
Y
F
Site 36
Y731
D
P
D
V
H
L
K
Y
I
Q
A
A
C
K
T
Site 37
S751
V
E
R
I
C
R
E
S
S
C
Y
N
P
E
R
Site 38
S752
E
R
I
C
R
E
S
S
C
Y
N
P
E
R
V
Site 39
Y754
I
C
R
E
S
S
C
Y
N
P
E
R
V
K
N
Site 40
Y792
H
D
L
V
L
Y
L
Y
R
N
N
L
Q
R
Y
Site 41
Y799
Y
R
N
N
L
Q
R
Y
I
E
I
Y
V
Q
K
Site 42
Y803
L
Q
R
Y
I
E
I
Y
V
Q
K
V
N
P
S
Site 43
T812
Q
K
V
N
P
S
R
T
P
A
V
I
G
G
L
Site 44
S864
L
L
L
P
W
L
E
S
Q
I
Q
E
G
C
E
Site 45
T875
E
G
C
E
E
P
A
T
H
N
A
L
A
K
I
Site 46
S889
I
Y
I
D
S
N
N
S
P
E
C
F
L
R
E
Site 47
Y899
C
F
L
R
E
N
A
Y
Y
D
S
S
V
V
G
Site 48
Y900
F
L
R
E
N
A
Y
Y
D
S
S
V
V
G
R
Site 49
S902
R
E
N
A
Y
Y
D
S
S
V
V
G
R
Y
C
Site 50
Y921
P
H
L
A
C
V
A
Y
E
R
G
Q
C
D
L
Site 51
S938
I
K
V
C
N
E
N
S
L
F
K
S
E
A
R
Site 52
S942
N
E
N
S
L
F
K
S
E
A
R
Y
L
V
C
Site 53
Y946
L
F
K
S
E
A
R
Y
L
V
C
R
K
D
P
Site 54
S966
V
L
E
E
T
N
P
S
R
R
Q
L
I
D
Q
Site 55
S989
T
R
D
P
E
E
I
S
V
T
V
K
A
F
M
Site 56
S1016
E
K
I
V
L
D
N
S
V
F
S
E
H
R
N
Site 57
S1019
V
L
D
N
S
V
F
S
E
H
R
N
L
Q
N
Site 58
Y1043
D
R
T
R
V
M
E
Y
I
S
R
L
D
N
Y
Site 59
Y1050
Y
I
S
R
L
D
N
Y
D
A
L
D
I
A
S
Site 60
Y1096
I
G
N
L
D
R
A
Y
E
F
A
E
R
C
N
Site 61
S1127
L
V
K
E
A
I
N
S
Y
I
R
G
D
D
P
Site 62
Y1128
V
K
E
A
I
N
S
Y
I
R
G
D
D
P
S
Site 63
S1135
Y
I
R
G
D
D
P
S
S
Y
L
E
V
V
Q
Site 64
S1136
I
R
G
D
D
P
S
S
Y
L
E
V
V
Q
S
Site 65
Y1137
R
G
D
D
P
S
S
Y
L
E
V
V
Q
S
A
Site 66
S1143
S
Y
L
E
V
V
Q
S
A
S
R
S
N
N
W
Site 67
S1147
V
V
Q
S
A
S
R
S
N
N
W
E
D
L
V
Site 68
S1167
A
R
K
K
G
R
E
S
Y
I
E
T
E
L
I
Site 69
Y1168
R
K
K
G
R
E
S
Y
I
E
T
E
L
I
F
Site 70
S1184
L
A
K
T
S
R
V
S
E
L
E
D
F
I
N
Site 71
Y1206
Q
Q
V
G
D
R
C
Y
E
E
G
M
Y
E
A
Site 72
Y1211
R
C
Y
E
E
G
M
Y
E
A
A
K
L
L
Y
Site 73
Y1218
Y
E
A
A
K
L
L
Y
S
N
V
S
N
F
A
Site 74
S1219
E
A
A
K
L
L
Y
S
N
V
S
N
F
A
R
Site 75
S1222
K
L
L
Y
S
N
V
S
N
F
A
R
L
A
S
Site 76
S1244
Y
Q
A
A
V
D
N
S
R
K
A
S
S
T
R
Site 77
S1248
V
D
N
S
R
K
A
S
S
T
R
T
W
K
E
Site 78
S1249
D
N
S
R
K
A
S
S
T
R
T
W
K
E
V
Site 79
T1250
N
S
R
K
A
S
S
T
R
T
W
K
E
V
C
Site 80
T1252
R
K
A
S
S
T
R
T
W
K
E
V
C
F
A
Site 81
Y1289
E
L
E
E
L
M
C
Y
Y
Q
D
R
G
Y
F
Site 82
Y1290
L
E
E
L
M
C
Y
Y
Q
D
R
G
Y
F
E
Site 83
Y1295
C
Y
Y
Q
D
R
G
Y
F
E
E
L
I
L
L
Site 84
Y1324
F
T
E
L
A
I
L
Y
S
K
F
K
P
Q
K
Site 85
S1325
T
E
L
A
I
L
Y
S
K
F
K
P
Q
K
M
Site 86
S1341
E
H
L
E
L
F
W
S
R
V
N
I
P
K
V
Site 87
Y1365
W
A
E
L
V
F
L
Y
D
K
Y
E
E
Y
D
Site 88
Y1368
L
V
F
L
Y
D
K
Y
E
E
Y
D
N
A
V
Site 89
Y1371
L
Y
D
K
Y
E
E
Y
D
N
A
V
L
T
M
Site 90
T1377
E
Y
D
N
A
V
L
T
M
M
S
H
P
T
E
Site 91
S1427
N
D
L
L
L
V
L
S
P
R
L
D
H
T
W
Site 92
T1433
L
S
P
R
L
D
H
T
W
T
V
S
F
F
S
Site 93
T1435
P
R
L
D
H
T
W
T
V
S
F
F
S
K
A
Site 94
S1437
L
D
H
T
W
T
V
S
F
F
S
K
A
G
Q
Site 95
Y1451
Q
L
P
L
V
K
P
Y
L
R
S
V
Q
S
H
Site 96
S1457
P
Y
L
R
S
V
Q
S
H
N
N
K
S
V
N
Site 97
S1462
V
Q
S
H
N
N
K
S
V
N
E
A
L
N
H
Site 98
T1472
E
A
L
N
H
L
L
T
E
E
E
D
Y
Q
G
Site 99
Y1477
L
L
T
E
E
E
D
Y
Q
G
L
R
A
S
I
Site 100
S1483
D
Y
Q
G
L
R
A
S
I
D
A
Y
D
N
F
Site 101
Y1487
L
R
A
S
I
D
A
Y
D
N
F
D
N
I
S
Site 102
S1494
Y
D
N
F
D
N
I
S
L
A
Q
Q
L
E
K
Site 103
Y1513
E
F
R
C
I
A
A
Y
L
Y
K
G
N
N
W
Site 104
Y1534
L
C
K
K
D
H
L
Y
K
D
A
M
Q
H
A
Site 105
Y1606
F
I
Q
V
M
R
E
Y
L
S
K
V
D
K
L
Site 106
S1618
D
K
L
D
A
L
E
S
L
R
K
Q
E
E
H
Site 107
T1627
R
K
Q
E
E
H
V
T
E
P
A
P
L
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation