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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BLM
Full Name:
Bloom syndrome protein
Alias:
Bloom Syndrome; Bloom syndrome, RecQ helicase-like; Bloom's syndrome protein; BS; DNA helicase, RecQ-like, type 2; RecQ protein-like 3; RECQ2; RECQL3
Type:
EC 3.6.1.-; DNA repair; DNA replication; Helicase
Mass (Da):
159000
Number AA:
1417
UniProt ID:
P54132
International Prot ID:
IPI00004859
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0005737
GO:0000800
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0043140
GO:0000739
PhosphoSite+
KinaseNET
Biological Process:
GO:0000085
GO:0031572
GO:0000724
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
Q
E
Q
L
E
R
H
S
A
R
T
L
N
N
K
Site 2
T20
L
E
R
H
S
A
R
T
L
N
N
K
L
S
L
Site 3
S26
R
T
L
N
N
K
L
S
L
S
K
P
K
F
S
Site 4
S28
L
N
N
K
L
S
L
S
K
P
K
F
S
G
F
Site 5
T36
K
P
K
F
S
G
F
T
F
K
K
K
T
S
S
Site 6
T41
G
F
T
F
K
K
K
T
S
S
D
N
N
V
S
Site 7
S43
T
F
K
K
K
T
S
S
D
N
N
V
S
V
T
Site 8
S48
T
S
S
D
N
N
V
S
V
T
N
V
S
V
A
Site 9
S53
N
V
S
V
T
N
V
S
V
A
K
T
P
V
L
Site 10
T57
T
N
V
S
V
A
K
T
P
V
L
R
N
K
D
Site 11
T68
R
N
K
D
V
N
V
T
E
D
F
S
F
S
E
Site 12
S72
V
N
V
T
E
D
F
S
F
S
E
P
L
P
N
Site 13
S74
V
T
E
D
F
S
F
S
E
P
L
P
N
T
T
Site 14
T99
N
A
P
A
G
Q
E
T
Q
R
G
G
S
K
S
Site 15
S104
Q
E
T
Q
R
G
G
S
K
S
L
L
P
D
F
Site 16
S106
T
Q
R
G
G
S
K
S
L
L
P
D
F
L
Q
Site 17
T114
L
L
P
D
F
L
Q
T
P
K
E
V
V
C
T
Site 18
T121
T
P
K
E
V
V
C
T
T
Q
N
T
P
T
V
Site 19
T122
P
K
E
V
V
C
T
T
Q
N
T
P
T
V
K
Site 20
T125
V
V
C
T
T
Q
N
T
P
T
V
K
K
S
R
Site 21
T127
C
T
T
Q
N
T
P
T
V
K
K
S
R
D
T
Site 22
T134
T
V
K
K
S
R
D
T
A
L
K
K
L
E
F
Site 23
S142
A
L
K
K
L
E
F
S
S
S
P
D
S
L
S
Site 24
S143
L
K
K
L
E
F
S
S
S
P
D
S
L
S
T
Site 25
S144
K
K
L
E
F
S
S
S
P
D
S
L
S
T
I
Site 26
S147
E
F
S
S
S
P
D
S
L
S
T
I
N
D
W
Site 27
S149
S
S
S
P
D
S
L
S
T
I
N
D
W
D
D
Site 28
T162
D
D
M
D
D
F
D
T
S
E
T
S
K
S
F
Site 29
S163
D
M
D
D
F
D
T
S
E
T
S
K
S
F
V
Site 30
S166
D
F
D
T
S
E
T
S
K
S
F
V
T
P
P
Site 31
S168
D
T
S
E
T
S
K
S
F
V
T
P
P
Q
S
Site 32
T171
E
T
S
K
S
F
V
T
P
P
Q
S
H
F
V
Site 33
S175
S
F
V
T
P
P
Q
S
H
F
V
R
V
S
T
Site 34
S181
Q
S
H
F
V
R
V
S
T
A
Q
K
S
K
K
Site 35
T182
S
H
F
V
R
V
S
T
A
Q
K
S
K
K
G
Site 36
S186
R
V
S
T
A
Q
K
S
K
K
G
K
R
N
F
Site 37
Y199
N
F
F
K
A
Q
L
Y
T
T
N
T
V
K
T
Site 38
T201
F
K
A
Q
L
Y
T
T
N
T
V
K
T
D
L
Site 39
T203
A
Q
L
Y
T
T
N
T
V
K
T
D
L
P
P
Site 40
T206
Y
T
T
N
T
V
K
T
D
L
P
P
P
S
S
Site 41
S212
K
T
D
L
P
P
P
S
S
E
S
E
Q
I
D
Site 42
S213
T
D
L
P
P
P
S
S
E
S
E
Q
I
D
L
Site 43
T221
E
S
E
Q
I
D
L
T
E
E
Q
K
D
D
S
Site 44
S228
T
E
E
Q
K
D
D
S
E
W
L
S
S
D
V
Site 45
S232
K
D
D
S
E
W
L
S
S
D
V
I
C
I
D
Site 46
S233
D
D
S
E
W
L
S
S
D
V
I
C
I
D
D
Site 47
S255
I
N
E
D
A
Q
E
S
D
S
L
K
T
H
L
Site 48
S257
E
D
A
Q
E
S
D
S
L
K
T
H
L
E
D
Site 49
S269
L
E
D
E
R
D
N
S
E
K
K
K
N
L
E
Site 50
T283
E
E
A
E
L
H
S
T
E
K
V
P
C
I
E
Site 51
Y296
I
E
F
D
D
D
D
Y
D
T
D
F
V
P
P
Site 52
T298
F
D
D
D
D
Y
D
T
D
F
V
P
P
S
P
Site 53
S304
D
T
D
F
V
P
P
S
P
E
E
I
I
S
A
Site 54
S310
P
S
P
E
E
I
I
S
A
S
S
S
S
S
K
Site 55
S312
P
E
E
I
I
S
A
S
S
S
S
S
K
C
L
Site 56
S313
E
E
I
I
S
A
S
S
S
S
S
K
C
L
S
Site 57
S314
E
I
I
S
A
S
S
S
S
S
K
C
L
S
T
Site 58
S316
I
S
A
S
S
S
S
S
K
C
L
S
T
L
K
Site 59
S320
S
S
S
S
K
C
L
S
T
L
K
D
L
D
T
Site 60
T321
S
S
S
K
C
L
S
T
L
K
D
L
D
T
S
Site 61
T327
S
T
L
K
D
L
D
T
S
D
R
K
E
D
V
Site 62
S328
T
L
K
D
L
D
T
S
D
R
K
E
D
V
L
Site 63
S336
D
R
K
E
D
V
L
S
T
S
K
D
L
L
S
Site 64
T337
R
K
E
D
V
L
S
T
S
K
D
L
L
S
K
Site 65
S338
K
E
D
V
L
S
T
S
K
D
L
L
S
K
P
Site 66
S343
S
T
S
K
D
L
L
S
K
P
E
K
M
S
M
Site 67
S358
Q
E
L
N
P
E
T
S
T
D
C
D
A
R
Q
Site 68
S367
D
C
D
A
R
Q
I
S
L
Q
Q
Q
L
I
H
Site 69
T385
H
I
C
K
L
I
D
T
I
P
D
D
K
L
K
Site 70
T412
N
I
R
R
K
L
L
T
E
V
D
F
N
K
S
Site 71
S419
T
E
V
D
F
N
K
S
D
A
S
L
L
G
S
Site 72
S422
D
F
N
K
S
D
A
S
L
L
G
S
L
W
R
Site 73
S426
S
D
A
S
L
L
G
S
L
W
R
Y
R
P
D
Site 74
Y430
L
L
G
S
L
W
R
Y
R
P
D
S
L
D
G
Site 75
S434
L
W
R
Y
R
P
D
S
L
D
G
P
M
E
G
Site 76
S443
D
G
P
M
E
G
D
S
C
P
T
G
N
S
M
Site 77
S456
S
M
K
E
L
N
F
S
H
L
P
S
N
S
V
Site 78
S460
L
N
F
S
H
L
P
S
N
S
V
S
P
G
D
Site 79
S462
F
S
H
L
P
S
N
S
V
S
P
G
D
C
L
Site 80
S464
H
L
P
S
N
S
V
S
P
G
D
C
L
L
T
Site 81
T471
S
P
G
D
C
L
L
T
T
T
L
G
K
T
G
Site 82
S480
T
L
G
K
T
G
F
S
A
T
R
K
N
L
F
Site 83
T494
F
E
R
P
L
F
N
T
H
L
Q
K
S
F
V
Site 84
S499
F
N
T
H
L
Q
K
S
F
V
S
S
N
W
A
Site 85
S503
L
Q
K
S
F
V
S
S
N
W
A
E
T
P
R
Site 86
T508
V
S
S
N
W
A
E
T
P
R
L
G
K
K
N
Site 87
S518
L
G
K
K
N
E
S
S
Y
F
P
G
N
V
L
Site 88
Y519
G
K
K
N
E
S
S
Y
F
P
G
N
V
L
T
Site 89
T528
P
G
N
V
L
T
S
T
A
V
K
D
Q
N
K
Site 90
S539
D
Q
N
K
H
T
A
S
I
N
D
L
E
R
E
Site 91
T547
I
N
D
L
E
R
E
T
Q
P
S
Y
D
I
D
Site 92
S550
L
E
R
E
T
Q
P
S
Y
D
I
D
N
F
D
Site 93
Y551
E
R
E
T
Q
P
S
Y
D
I
D
N
F
D
I
Site 94
S577
I
M
H
N
L
A
A
S
K
S
S
T
A
A
Y
Site 95
S579
H
N
L
A
A
S
K
S
S
T
A
A
Y
Q
P
Site 96
T581
L
A
A
S
K
S
S
T
A
A
Y
Q
P
I
K
Site 97
Y584
S
K
S
S
T
A
A
Y
Q
P
I
K
E
G
R
Site 98
S595
K
E
G
R
P
I
K
S
V
S
E
R
L
S
S
Site 99
S597
G
R
P
I
K
S
V
S
E
R
L
S
S
A
K
Site 100
S601
K
S
V
S
E
R
L
S
S
A
K
T
D
C
L
Site 101
S602
S
V
S
E
R
L
S
S
A
K
T
D
C
L
P
Site 102
T605
E
R
L
S
S
A
K
T
D
C
L
P
V
S
S
Site 103
S611
K
T
D
C
L
P
V
S
S
T
A
Q
N
I
N
Site 104
S612
T
D
C
L
P
V
S
S
T
A
Q
N
I
N
F
Site 105
Y626
F
S
E
S
I
Q
N
Y
T
D
K
S
A
Q
N
Site 106
S630
I
Q
N
Y
T
D
K
S
A
Q
N
L
A
S
R
Site 107
S646
L
K
H
E
R
F
Q
S
L
S
F
P
H
T
K
Site 108
S648
H
E
R
F
Q
S
L
S
F
P
H
T
K
E
M
Site 109
T652
Q
S
L
S
F
P
H
T
K
E
M
M
K
I
F
Site 110
S696
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
Site 111
S714
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
Site 112
T735
T
S
L
D
I
P
A
T
Y
L
T
G
D
K
T
Site 113
Y736
S
L
D
I
P
A
T
Y
L
T
G
D
K
T
D
Site 114
T742
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
Site 115
S744
L
T
G
D
K
T
D
S
E
A
T
N
I
Y
L
Site 116
Y750
D
S
E
A
T
N
I
Y
L
Q
L
S
K
K
D
Site 117
S754
T
N
I
Y
L
Q
L
S
K
K
D
P
I
I
K
Site 118
T766
I
I
K
L
L
Y
V
T
P
E
K
I
C
A
S
Site 119
S773
T
P
E
K
I
C
A
S
N
R
L
I
S
T
L
Site 120
S778
C
A
S
N
R
L
I
S
T
L
E
N
L
Y
E
Site 121
Y784
I
S
T
L
E
N
L
Y
E
R
K
L
L
A
R
Site 122
Y811
G
H
D
F
R
Q
D
Y
K
R
M
N
M
L
R
Site 123
T832
P
V
M
A
L
T
A
T
A
N
P
R
V
Q
K
Site 124
T843
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Site 125
S856
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
Site 126
Y864
F
N
R
H
N
L
K
Y
Y
V
L
P
K
K
P
Site 127
Y865
N
R
H
N
L
K
Y
Y
V
L
P
K
K
P
K
Site 128
Y894
P
Y
D
S
G
I
I
Y
C
L
S
R
R
E
C
Site 129
T903
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
Site 130
T907
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
Site 131
S923
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Site 132
S925
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
Site 133
S969
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
Site 134
Y973
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
Site 135
Y974
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
Site 136
S977
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
Site 137
S987
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Site 138
Y995
H
C
L
L
F
Y
T
Y
H
D
V
T
R
L
K
Site 139
Y1024
E
T
H
F
N
N
L
Y
S
M
V
H
Y
C
E
Site 140
Y1044
R
R
I
Q
L
L
A
Y
F
G
E
N
G
F
N
Site 141
Y1072
N
C
C
K
T
K
D
Y
K
T
R
D
V
T
D
Site 142
T1074
C
K
T
K
D
Y
K
T
R
D
V
T
D
D
V
Site 143
T1078
D
Y
K
T
R
D
V
T
D
D
V
K
S
I
V
Site 144
S1083
D
V
T
D
D
V
K
S
I
V
R
F
V
Q
E
Site 145
S1093
R
F
V
Q
E
H
S
S
S
Q
G
M
R
N
I
Site 146
S1094
F
V
Q
E
H
S
S
S
Q
G
M
R
N
I
K
Site 147
S1128
S
K
S
A
K
I
Q
S
G
I
F
G
K
G
S
Site 148
S1135
S
G
I
F
G
K
G
S
A
Y
S
R
H
N
A
Site 149
Y1137
I
F
G
K
G
S
A
Y
S
R
H
N
A
E
R
Site 150
Y1160
K
I
L
D
E
D
L
Y
I
N
A
N
D
Q
A
Site 151
T1179
M
L
G
N
K
A
Q
T
V
L
N
G
N
L
K
Site 152
T1192
L
K
V
D
F
M
E
T
E
N
S
S
S
V
K
Site 153
S1195
D
F
M
E
T
E
N
S
S
S
V
K
K
Q
K
Site 154
S1197
M
E
T
E
N
S
S
S
V
K
K
Q
K
A
L
Site 155
S1209
K
A
L
V
A
K
V
S
Q
R
E
E
M
V
K
Site 156
T1223
K
K
C
L
G
E
L
T
E
V
C
K
S
L
G
Site 157
S1252
T
L
K
K
L
A
E
S
L
S
S
D
P
E
V
Site 158
S1254
K
K
L
A
E
S
L
S
S
D
P
E
V
L
L
Site 159
S1255
K
L
A
E
S
L
S
S
D
P
E
V
L
L
Q
Site 160
Y1274
T
E
D
K
L
E
K
Y
G
A
E
V
I
S
V
Site 161
Y1285
V
I
S
V
L
Q
K
Y
S
E
W
T
S
P
A
Site 162
S1286
I
S
V
L
Q
K
Y
S
E
W
T
S
P
A
E
Site 163
S1290
Q
K
Y
S
E
W
T
S
P
A
E
D
S
S
P
Site 164
S1295
W
T
S
P
A
E
D
S
S
P
G
I
S
L
S
Site 165
S1296
T
S
P
A
E
D
S
S
P
G
I
S
L
S
S
Site 166
S1300
E
D
S
S
P
G
I
S
L
S
S
S
R
G
P
Site 167
S1302
S
S
P
G
I
S
L
S
S
S
R
G
P
G
R
Site 168
S1303
S
P
G
I
S
L
S
S
S
R
G
P
G
R
S
Site 169
S1304
P
G
I
S
L
S
S
S
R
G
P
G
R
S
A
Site 170
S1310
S
S
R
G
P
G
R
S
A
A
E
E
L
D
E
Site 171
S1322
L
D
E
E
I
P
V
S
S
H
Y
F
A
S
K
Site 172
Y1325
E
I
P
V
S
S
H
Y
F
A
S
K
T
R
N
Site 173
S1328
V
S
S
H
Y
F
A
S
K
T
R
N
E
R
K
Site 174
T1330
S
H
Y
F
A
S
K
T
R
N
E
R
K
R
K
Site 175
S1342
K
R
K
K
M
P
A
S
Q
R
S
K
R
R
K
Site 176
S1345
K
M
P
A
S
Q
R
S
K
R
R
K
T
A
S
Site 177
T1350
Q
R
S
K
R
R
K
T
A
S
S
G
S
K
A
Site 178
S1352
S
K
R
R
K
T
A
S
S
G
S
K
A
K
G
Site 179
S1353
K
R
R
K
T
A
S
S
G
S
K
A
K
G
G
Site 180
S1355
R
K
T
A
S
S
G
S
K
A
K
G
G
S
A
Site 181
T1363
K
A
K
G
G
S
A
T
C
R
K
I
S
S
K
Site 182
S1368
S
A
T
C
R
K
I
S
S
K
T
K
S
S
S
Site 183
S1369
A
T
C
R
K
I
S
S
K
T
K
S
S
S
I
Site 184
T1371
C
R
K
I
S
S
K
T
K
S
S
S
I
I
G
Site 185
S1373
K
I
S
S
K
T
K
S
S
S
I
I
G
S
S
Site 186
S1374
I
S
S
K
T
K
S
S
S
I
I
G
S
S
S
Site 187
S1375
S
S
K
T
K
S
S
S
I
I
G
S
S
S
A
Site 188
S1379
K
S
S
S
I
I
G
S
S
S
A
S
H
T
S
Site 189
S1380
S
S
S
I
I
G
S
S
S
A
S
H
T
S
Q
Site 190
S1381
S
S
I
I
G
S
S
S
A
S
H
T
S
Q
A
Site 191
S1383
I
I
G
S
S
S
A
S
H
T
S
Q
A
T
S
Site 192
T1385
G
S
S
S
A
S
H
T
S
Q
A
T
S
G
A
Site 193
S1386
S
S
S
A
S
H
T
S
Q
A
T
S
G
A
N
Site 194
S1390
S
H
T
S
Q
A
T
S
G
A
N
S
K
L
G
Site 195
S1394
Q
A
T
S
G
A
N
S
K
L
G
I
M
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation