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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TERF1
Full Name:
Telomeric repeat-binding factor 1
Alias:
NIMA-interacting protein 2; PIN2; Telomeric protein Pin2/TRF1; Telomeric repeat binding factor (NIMA-interacting) 1; Telomeric repeat binding factor 1; TRBF1; TRF; TTAGGG repeat binding factor 1; TTAGGG repeat-binding factor 1
Type:
DNA binding protein
Mass (Da):
50246
Number AA:
439
UniProt ID:
P54274
International Prot ID:
IPI00005539
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000781
GO:0000783
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008301
GO:0008656
GO:0003691
PhosphoSite+
KinaseNET
Biological Process:
GO:0000086
GO:0006919
GO:0001309
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
E
D
V
S
S
A
A
P
S
P
R
Site 2
S7
_
M
A
E
D
V
S
S
A
A
P
S
P
R
G
Site 3
S11
D
V
S
S
A
A
P
S
P
R
G
C
A
D
G
Site 4
T24
D
G
R
D
A
D
P
T
E
E
Q
M
A
E
T
Site 5
T101
R
S
E
D
F
R
R
T
R
N
S
A
E
A
I
Site 6
S104
D
F
R
R
T
R
N
S
A
E
A
I
I
H
G
Site 7
T122
L
T
A
C
Q
L
R
T
I
Y
I
C
Q
F
L
Site 8
T149
F
E
N
D
E
R
I
T
P
L
E
S
A
L
M
Site 9
S160
S
A
L
M
I
W
G
S
I
E
K
E
H
D
K
Site 10
S206
R
I
F
G
D
P
N
S
H
M
P
F
K
S
K
Site 11
S219
S
K
L
L
M
I
I
S
Q
K
D
T
F
H
S
Site 12
Y243
M
M
E
K
I
K
S
Y
V
N
Y
V
L
S
E
Site 13
Y246
K
I
K
S
Y
V
N
Y
V
L
S
E
K
S
S
Site 14
S249
S
Y
V
N
Y
V
L
S
E
K
S
S
T
F
L
Site 15
S252
N
Y
V
L
S
E
K
S
S
T
F
L
M
K
A
Site 16
S253
Y
V
L
S
E
K
S
S
T
F
L
M
K
A
A
Site 17
T254
V
L
S
E
K
S
S
T
F
L
M
K
A
A
A
Site 18
S266
A
A
A
K
V
V
E
S
K
R
T
R
T
I
T
Site 19
T269
K
V
V
E
S
K
R
T
R
T
I
T
S
Q
D
Site 20
T271
V
E
S
K
R
T
R
T
I
T
S
Q
D
K
P
Site 21
T273
S
K
R
T
R
T
I
T
S
Q
D
K
P
S
G
Site 22
S274
K
R
T
R
T
I
T
S
Q
D
K
P
S
G
N
Site 23
T287
G
N
D
V
E
M
E
T
E
A
N
L
D
T
R
Site 24
S296
A
N
L
D
T
R
K
S
V
S
D
K
Q
S
A
Site 25
S302
K
S
V
S
D
K
Q
S
A
V
T
E
S
S
E
Site 26
T305
S
D
K
Q
S
A
V
T
E
S
S
E
G
T
V
Site 27
S307
K
Q
S
A
V
T
E
S
S
E
G
T
V
S
L
Site 28
S308
Q
S
A
V
T
E
S
S
E
G
T
V
S
L
L
Site 29
T311
V
T
E
S
S
E
G
T
V
S
L
L
R
S
H
Site 30
S313
E
S
S
E
G
T
V
S
L
L
R
S
H
K
N
Site 31
S324
S
H
K
N
L
F
L
S
K
L
Q
H
G
T
Q
Site 32
T344
K
K
E
R
R
V
G
T
P
Q
S
T
K
K
K
Site 33
S347
R
R
V
G
T
P
Q
S
T
K
K
K
K
E
S
Site 34
S354
S
T
K
K
K
K
E
S
R
R
A
T
E
S
R
Site 35
T358
K
K
E
S
R
R
A
T
E
S
R
I
P
V
S
Site 36
S360
E
S
R
R
A
T
E
S
R
I
P
V
S
K
S
Site 37
S365
T
E
S
R
I
P
V
S
K
S
Q
P
V
T
P
Site 38
S367
S
R
I
P
V
S
K
S
Q
P
V
T
P
E
K
Site 39
T371
V
S
K
S
Q
P
V
T
P
E
K
H
R
A
R
Site 40
S393
E
E
D
K
N
L
R
S
G
V
R
K
Y
G
E
Site 41
Y398
L
R
S
G
V
R
K
Y
G
E
G
N
W
S
K
Site 42
T426
M
L
K
D
R
W
R
T
M
K
K
L
K
L
I
Site 43
S434
M
K
K
L
K
L
I
S
S
D
S
E
D
_
_
Site 44
S435
K
K
L
K
L
I
S
S
D
S
E
D
_
_
_
Site 45
S437
L
K
L
I
S
S
D
S
E
D
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation