KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Myomesin 2
Full Name:
Myomesin-2
Alias:
165 kDa connectin-associated protein;165 kDa titin-associated protein;M-protein;Myomesin family member 2
Type:
Cytoskeletal protein
Mass (Da):
164794
Number AA:
1465
UniProt ID:
P54296
International Prot ID:
IPI00005587
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032982
Uniprot
OncoNet
Molecular Function:
GO:0008307
PhosphoSite+
KinaseNET
Biological Process:
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
S
L
V
T
V
P
F
Y
Q
K
R
H
R
H
F
Site 2
S19
R
H
R
H
F
D
Q
S
Y
R
N
I
Q
T
R
Site 3
Y20
H
R
H
F
D
Q
S
Y
R
N
I
Q
T
R
Y
Site 4
Y32
T
R
Y
L
L
D
E
Y
A
S
K
K
R
A
S
Site 5
S34
Y
L
L
D
E
Y
A
S
K
K
R
A
S
T
Q
Site 6
S39
Y
A
S
K
K
R
A
S
T
Q
A
S
S
Q
K
Site 7
T40
A
S
K
K
R
A
S
T
Q
A
S
S
Q
K
S
Site 8
S43
K
R
A
S
T
Q
A
S
S
Q
K
S
L
S
Q
Site 9
S44
R
A
S
T
Q
A
S
S
Q
K
S
L
S
Q
R
Site 10
S47
T
Q
A
S
S
Q
K
S
L
S
Q
R
S
S
S
Site 11
S49
A
S
S
Q
K
S
L
S
Q
R
S
S
S
Q
R
Site 12
S53
K
S
L
S
Q
R
S
S
S
Q
R
A
S
S
Q
Site 13
S54
S
L
S
Q
R
S
S
S
Q
R
A
S
S
Q
T
Site 14
S58
R
S
S
S
Q
R
A
S
S
Q
T
S
L
G
G
Site 15
S59
S
S
S
Q
R
A
S
S
Q
T
S
L
G
G
T
Site 16
T61
S
Q
R
A
S
S
Q
T
S
L
G
G
T
I
C
Site 17
S62
Q
R
A
S
S
Q
T
S
L
G
G
T
I
C
R
Site 18
T66
S
Q
T
S
L
G
G
T
I
C
R
V
C
A
K
Site 19
S76
R
V
C
A
K
R
V
S
T
Q
E
D
E
E
Q
Site 20
T77
V
C
A
K
R
V
S
T
Q
E
D
E
E
Q
E
Site 21
Y89
E
Q
E
N
R
S
R
Y
Q
S
L
V
A
A
Y
Site 22
S91
E
N
R
S
R
Y
Q
S
L
V
A
A
Y
G
E
Site 23
Y96
Y
Q
S
L
V
A
A
Y
G
E
A
K
R
Q
R
Site 24
S106
A
K
R
Q
R
F
L
S
E
L
A
H
L
E
E
Site 25
S120
E
D
V
H
L
A
R
S
Q
A
R
D
K
L
D
Site 26
Y129
A
R
D
K
L
D
K
Y
A
I
Q
Q
M
M
E
Site 27
T145
K
L
A
W
E
R
H
T
F
E
E
R
I
S
R
Site 28
S151
H
T
F
E
E
R
I
S
R
A
P
E
I
L
V
Site 29
S162
E
I
L
V
R
L
R
S
H
T
V
W
E
R
M
Site 30
T164
L
V
R
L
R
S
H
T
V
W
E
R
M
S
V
Site 31
T182
F
T
V
Q
G
F
P
T
P
V
V
Q
W
Y
K
Site 32
Y188
P
T
P
V
V
Q
W
Y
K
D
G
S
L
I
C
Site 33
Y203
Q
A
A
E
P
G
K
Y
R
I
E
S
N
Y
G
Site 34
S207
P
G
K
Y
R
I
E
S
N
Y
G
V
H
T
L
Site 35
Y209
K
Y
R
I
E
S
N
Y
G
V
H
T
L
E
I
Site 36
T224
N
R
A
D
F
D
D
T
A
T
Y
S
A
V
A
Site 37
T226
A
D
F
D
D
T
A
T
Y
S
A
V
A
T
N
Site 38
S228
F
D
D
T
A
T
Y
S
A
V
A
T
N
A
H
Site 39
T232
A
T
Y
S
A
V
A
T
N
A
H
G
Q
V
S
Site 40
S258
G
D
E
E
P
F
R
S
V
G
L
P
I
G
L
Site 41
T287
F
L
E
K
F
G
V
T
F
R
R
E
G
E
T
Site 42
T294
T
F
R
R
E
G
E
T
V
T
L
K
C
T
M
Site 43
T329
L
L
K
E
S
K
W
T
K
M
F
F
G
E
G
Site 44
S339
F
F
G
E
G
Q
A
S
L
S
F
S
H
L
H
Site 45
S341
G
E
G
Q
A
S
L
S
F
S
H
L
H
K
D
Site 46
S343
G
Q
A
S
L
S
F
S
H
L
H
K
D
D
E
Site 47
Y353
H
K
D
D
E
G
L
Y
T
L
R
I
V
S
R
Site 48
T354
K
D
D
E
G
L
Y
T
L
R
I
V
S
R
G
Site 49
S359
L
Y
T
L
R
I
V
S
R
G
G
V
S
D
H
Site 50
S367
R
G
G
V
S
D
H
S
A
F
L
F
V
R
D
Site 51
Y398
C
H
D
A
N
R
D
Y
V
I
V
T
W
K
P
Site 52
T402
N
R
D
Y
V
I
V
T
W
K
P
P
N
T
T
Site 53
T408
V
T
W
K
P
P
N
T
T
T
E
S
P
V
M
Site 54
T410
W
K
P
P
N
T
T
T
E
S
P
V
M
G
Y
Site 55
S412
P
P
N
T
T
T
E
S
P
V
M
G
Y
F
V
Site 56
Y417
T
E
S
P
V
M
G
Y
F
V
D
R
C
E
V
Site 57
Y442
A
P
V
K
I
C
K
Y
P
V
T
G
L
F
E
Site 58
T445
K
I
C
K
Y
P
V
T
G
L
F
E
G
R
S
Site 59
S452
T
G
L
F
E
G
R
S
Y
I
F
R
V
R
A
Site 60
S462
F
R
V
R
A
V
N
S
A
G
I
S
R
P
S
Site 61
S466
A
V
N
S
A
G
I
S
R
P
S
R
V
S
D
Site 62
S469
S
A
G
I
S
R
P
S
R
V
S
D
A
V
A
Site 63
S472
I
S
R
P
S
R
V
S
D
A
V
A
A
L
D
Site 64
Y500
G
E
K
E
I
A
I
Y
Q
D
D
L
E
G
D
Site 65
T515
A
Q
V
P
G
P
P
T
G
V
H
A
S
E
I
Site 66
S520
P
P
T
G
V
H
A
S
E
I
S
R
N
Y
V
Site 67
Y526
A
S
E
I
S
R
N
Y
V
V
L
S
W
E
P
Site 68
S530
S
R
N
Y
V
V
L
S
W
E
P
P
T
P
R
Site 69
T535
V
L
S
W
E
P
P
T
P
R
G
K
D
P
L
Site 70
Y544
R
G
K
D
P
L
M
Y
F
I
E
K
S
V
V
Site 71
S553
I
E
K
S
V
V
G
S
G
S
W
Q
R
V
N
Site 72
T563
W
Q
R
V
N
A
Q
T
A
V
R
S
P
R
Y
Site 73
S567
N
A
Q
T
A
V
R
S
P
R
Y
A
V
F
D
Site 74
Y570
T
A
V
R
S
P
R
Y
A
V
F
D
L
M
E
Site 75
S587
S
Y
V
F
R
V
L
S
A
N
R
H
G
L
S
Site 76
S594
S
A
N
R
H
G
L
S
E
P
S
E
I
T
S
Site 77
S597
R
H
G
L
S
E
P
S
E
I
T
S
P
I
Q
Site 78
S601
S
E
P
S
E
I
T
S
P
I
Q
A
Q
D
V
Site 79
T624
R
V
L
A
S
R
N
T
K
T
S
V
V
V
Q
Site 80
T626
L
A
S
R
N
T
K
T
S
V
V
V
Q
W
D
Site 81
S627
A
S
R
N
T
K
T
S
V
V
V
Q
W
D
R
Site 82
S696
A
V
G
M
S
E
N
S
Q
E
S
D
V
I
K
Site 83
S737
G
W
K
V
P
K
F
S
G
G
S
P
I
L
G
Site 84
Y745
G
G
S
P
I
L
G
Y
Y
L
D
K
R
E
V
Site 85
Y746
G
S
P
I
L
G
Y
Y
L
D
K
R
E
V
H
Site 86
S762
K
N
W
H
E
V
N
S
S
P
S
K
P
T
I
Site 87
S763
N
W
H
E
V
N
S
S
P
S
K
P
T
I
L
Site 88
T771
P
S
K
P
T
I
L
T
V
D
G
L
T
E
G
Site 89
S797
L
A
G
I
G
E
P
S
D
P
S
E
H
F
K
Site 90
S800
I
G
E
P
S
D
P
S
E
H
F
K
C
E
A
Site 91
Y817
M
P
E
P
G
P
A
Y
D
L
T
F
C
E
V
Site 92
T820
P
G
P
A
Y
D
L
T
F
C
E
V
R
D
T
Site 93
Y838
M
L
W
K
A
P
V
Y
S
G
S
S
P
V
S
Site 94
S839
L
W
K
A
P
V
Y
S
G
S
S
P
V
S
G
Site 95
S841
K
A
P
V
Y
S
G
S
S
P
V
S
G
Y
F
Site 96
S845
Y
S
G
S
S
P
V
S
G
Y
F
V
D
F
R
Site 97
Y847
G
S
S
P
V
S
G
Y
F
V
D
F
R
E
E
Site 98
T861
E
D
A
G
E
W
I
T
V
N
Q
T
T
T
A
Site 99
Y871
Q
T
T
T
A
N
R
Y
L
K
V
S
D
L
Q
Site 100
S875
A
N
R
Y
L
K
V
S
D
L
Q
Q
G
K
T
Site 101
T882
S
D
L
Q
Q
G
K
T
Y
V
F
R
V
R
A
Site 102
Y883
D
L
Q
Q
G
K
T
Y
V
F
R
V
R
A
V
Site 103
S899
A
N
G
V
G
K
P
S
D
T
S
E
P
V
L
Site 104
T901
G
V
G
K
P
S
D
T
S
E
P
V
L
V
E
Site 105
S902
V
G
K
P
S
D
T
S
E
P
V
L
V
E
A
Site 106
T913
L
V
E
A
R
P
G
T
K
E
I
S
A
G
V
Site 107
S917
R
P
G
T
K
E
I
S
A
G
V
D
E
Q
G
Site 108
Y927
V
D
E
Q
G
N
I
Y
L
G
F
D
C
Q
E
Site 109
T960
D
E
R
F
K
I
E
T
V
G
D
H
S
K
L
Site 110
Y968
V
G
D
H
S
K
L
Y
L
K
N
P
D
K
E
Site 111
T979
P
D
K
E
D
L
G
T
Y
S
V
S
V
S
D
Site 112
S981
K
E
D
L
G
T
Y
S
V
S
V
S
D
T
D
Site 113
S983
D
L
G
T
Y
S
V
S
V
S
D
T
D
G
V
Site 114
S985
G
T
Y
S
V
S
V
S
D
T
D
G
V
S
S
Site 115
T987
Y
S
V
S
V
S
D
T
D
G
V
S
S
S
F
Site 116
S991
V
S
D
T
D
G
V
S
S
S
F
V
L
D
P
Site 117
S993
D
T
D
G
V
S
S
S
F
V
L
D
P
E
E
Site 118
S1008
L
E
R
L
M
A
L
S
N
E
I
K
N
P
T
Site 119
S1020
N
P
T
I
P
L
K
S
E
L
A
Y
E
I
F
Site 120
Y1024
P
L
K
S
E
L
A
Y
E
I
F
D
K
G
R
Site 121
S1042
W
L
Q
A
E
H
L
S
P
D
A
S
Y
R
F
Site 122
S1046
E
H
L
S
P
D
A
S
Y
R
F
I
I
N
D
Site 123
Y1047
H
L
S
P
D
A
S
Y
R
F
I
I
N
D
R
Site 124
S1057
I
I
N
D
R
E
V
S
D
S
E
I
H
R
I
Site 125
S1059
N
D
R
E
V
S
D
S
E
I
H
R
I
K
C
Site 126
T1070
R
I
K
C
D
K
A
T
G
I
I
E
M
V
M
Site 127
S1081
E
M
V
M
D
R
F
S
I
E
N
E
G
T
Y
Site 128
T1087
F
S
I
E
N
E
G
T
Y
T
V
Q
I
H
D
Site 129
Y1088
S
I
E
N
E
G
T
Y
T
V
Q
I
H
D
G
Site 130
T1089
I
E
N
E
G
T
Y
T
V
Q
I
H
D
G
K
Site 131
S1099
I
H
D
G
K
A
K
S
Q
S
S
L
V
L
I
Site 132
S1101
D
G
K
A
K
S
Q
S
S
L
V
L
I
G
D
Site 133
S1102
G
K
A
K
S
Q
S
S
L
V
L
I
G
D
A
Site 134
T1112
L
I
G
D
A
F
K
T
V
L
E
E
A
E
F
Site 135
Y1135
Q
G
P
H
F
A
E
Y
L
H
W
D
V
T
E
Site 136
T1141
E
Y
L
H
W
D
V
T
E
E
C
E
V
R
L
Site 137
Y1170
W
L
K
D
D
V
L
Y
E
T
E
T
L
P
N
Site 138
T1174
D
V
L
Y
E
T
E
T
L
P
N
L
E
R
G
Site 139
S1191
E
L
L
I
P
K
L
S
K
K
D
H
G
E
Y
Site 140
T1201
D
H
G
E
Y
K
A
T
L
K
D
D
R
G
Q
Site 141
S1211
D
D
R
G
Q
D
V
S
I
L
E
I
A
G
K
Site 142
Y1255
R
L
Q
C
F
M
K
Y
F
T
D
E
M
K
V
Site 143
S1272
C
H
K
D
A
K
I
S
S
S
E
H
M
R
I
Site 144
S1273
H
K
D
A
K
I
S
S
S
E
H
M
R
I
G
Site 145
S1274
K
D
A
K
I
S
S
S
E
H
M
R
I
G
G
Site 146
T1302
E
K
D
K
G
K
Y
T
F
E
I
F
D
G
K
Site 147
S1315
G
K
D
N
H
Q
R
S
L
D
L
S
G
Q
A
Site 148
S1319
H
Q
R
S
L
D
L
S
G
Q
A
F
D
E
A
Site 149
T1365
E
G
K
T
L
N
L
T
C
T
V
F
G
N
P
Site 150
T1367
K
T
L
N
L
T
C
T
V
F
G
N
P
D
P
Site 151
S1388
N
D
Q
D
I
Q
L
S
E
H
F
S
V
K
V
Site 152
S1392
I
Q
L
S
E
H
F
S
V
K
V
E
Q
A
K
Site 153
Y1400
V
K
V
E
Q
A
K
Y
V
S
M
T
I
K
G
Site 154
T1409
S
M
T
I
K
G
V
T
S
E
D
S
G
K
Y
Site 155
S1413
K
G
V
T
S
E
D
S
G
K
Y
S
I
N
I
Site 156
S1417
S
E
D
S
G
K
Y
S
I
N
I
K
N
K
Y
Site 157
Y1424
S
I
N
I
K
N
K
Y
G
G
E
K
I
D
V
Site 158
T1432
G
G
E
K
I
D
V
T
V
S
V
Y
K
H
G
Site 159
S1434
E
K
I
D
V
T
V
S
V
Y
K
H
G
E
K
Site 160
Y1436
I
D
V
T
V
S
V
Y
K
H
G
E
K
I
P
Site 161
S1459
K
P
K
L
I
P
A
S
A
S
A
A
G
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation