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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP14
Full Name:
Ubiquitin carboxyl-terminal hydrolase 14
Alias:
Deubiquitinating enzyme 14; EC 3.1.2.15; TGT; TRNA-guanine transglycosylase; TRNA-guanine transglycosylase, 60-kD subunit; Ubiquitin carboxyl-terminal hydrolase 14; Ubiquitin specific peptidase 14; Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); Ubiquitin specific protease 14; Ubiquitin thiolesterase 14; Ubiquitin-specific processing protease 14; Ubiquitin-specific-processing protease 14; UBP14
Type:
Ubiquitin conjugating system; Protease; EC 3.1.2.15
Mass (Da):
56069
Number AA:
494
UniProt ID:
P54578
International Prot ID:
IPI00219913
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0008193
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
P
L
Y
S
V
T
V
K
W
G
Site 2
T7
_
M
P
L
Y
S
V
T
V
K
W
G
K
E
K
Site 3
T22
F
E
G
V
E
L
N
T
D
E
P
P
M
V
F
Site 4
T86
P
E
E
P
S
A
K
T
V
F
V
E
D
M
T
Site 5
T93
T
V
F
V
E
D
M
T
E
E
Q
L
A
S
A
Site 6
S99
M
T
E
E
Q
L
A
S
A
M
E
L
P
C
G
Site 7
Y136
L
K
D
A
L
K
R
Y
A
G
A
L
R
A
S
Site 8
S143
Y
A
G
A
L
R
A
S
G
E
M
A
S
A
Q
Site 9
S148
R
A
S
G
E
M
A
S
A
Q
Y
I
T
A
A
Site 10
Y151
G
E
M
A
S
A
Q
Y
I
T
A
A
L
R
D
Site 11
S162
A
L
R
D
L
F
D
S
M
D
K
T
S
S
S
Site 12
T166
L
F
D
S
M
D
K
T
S
S
S
I
P
P
I
Site 13
S167
F
D
S
M
D
K
T
S
S
S
I
P
P
I
I
Site 14
Y195
E
K
G
E
Q
G
Q
Y
L
Q
Q
D
A
N
E
Site 15
S222
L
E
A
I
E
D
D
S
V
K
E
T
D
S
S
Site 16
T226
E
D
D
S
V
K
E
T
D
S
S
S
A
S
A
Site 17
S228
D
S
V
K
E
T
D
S
S
S
A
S
A
A
T
Site 18
S229
S
V
K
E
T
D
S
S
S
A
S
A
A
T
P
Site 19
S230
V
K
E
T
D
S
S
S
A
S
A
A
T
P
S
Site 20
S232
E
T
D
S
S
S
A
S
A
A
T
P
S
K
K
Site 21
T235
S
S
S
A
S
A
A
T
P
S
K
K
K
S
L
Site 22
S237
S
A
S
A
A
T
P
S
K
K
K
S
L
I
D
Site 23
S241
A
T
P
S
K
K
K
S
L
I
D
Q
F
F
G
Site 24
T254
F
G
V
E
F
E
T
T
M
K
C
T
E
S
E
Site 25
S260
T
T
M
K
C
T
E
S
E
E
E
E
V
T
K
Site 26
T266
E
S
E
E
E
E
V
T
K
G
K
E
N
Q
L
Site 27
S276
K
E
N
Q
L
Q
L
S
C
F
I
N
Q
E
V
Site 28
Y285
F
I
N
Q
E
V
K
Y
L
F
T
G
L
K
L
Site 29
T299
L
R
L
Q
E
E
I
T
K
Q
S
P
T
L
Q
Site 30
S302
Q
E
E
I
T
K
Q
S
P
T
L
Q
R
N
A
Site 31
Y311
T
L
Q
R
N
A
L
Y
I
K
S
S
K
I
S
Site 32
S314
R
N
A
L
Y
I
K
S
S
K
I
S
R
L
P
Site 33
S315
N
A
L
Y
I
K
S
S
K
I
S
R
L
P
A
Site 34
S318
Y
I
K
S
S
K
I
S
R
L
P
A
Y
L
T
Site 35
Y333
I
Q
M
V
R
F
F
Y
K
E
K
E
S
V
N
Site 36
T360
L
D
M
Y
E
L
C
T
P
E
L
Q
E
K
M
Site 37
S369
E
L
Q
E
K
M
V
S
F
R
S
K
F
K
D
Site 38
T388
K
V
N
Q
Q
P
N
T
S
D
K
K
S
S
P
Site 39
S389
V
N
Q
Q
P
N
T
S
D
K
K
S
S
P
Q
Site 40
S393
P
N
T
S
D
K
K
S
S
P
Q
K
E
V
K
Site 41
S394
N
T
S
D
K
K
S
S
P
Q
K
E
V
K
Y
Site 42
Y401
S
P
Q
K
E
V
K
Y
E
P
F
S
F
A
D
Site 43
S405
E
V
K
Y
E
P
F
S
F
A
D
D
I
G
S
Site 44
Y417
I
G
S
N
N
C
G
Y
Y
D
L
Q
A
V
L
Site 45
T425
Y
D
L
Q
A
V
L
T
H
Q
G
R
S
S
S
Site 46
S431
L
T
H
Q
G
R
S
S
S
S
G
H
Y
V
S
Site 47
S432
T
H
Q
G
R
S
S
S
S
G
H
Y
V
S
W
Site 48
S433
H
Q
G
R
S
S
S
S
G
H
Y
V
S
W
V
Site 49
Y436
R
S
S
S
S
G
H
Y
V
S
W
V
K
R
K
Site 50
S438
S
S
S
G
H
Y
V
S
W
V
K
R
K
Q
D
Site 51
T459
D
D
K
V
S
I
V
T
P
E
D
I
L
R
L
Site 52
S467
P
E
D
I
L
R
L
S
G
G
G
D
W
H
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation