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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC12A3
Full Name:
Solute carrier family 12 member 3
Alias:
Na-Cl symporter; NCC; S12A3; solute carrier family 12 (sodium/chloride transporters) member 3; Thiazide-sensitive sodium-chloride cotransporter; TSC
Type:
Membrane protein, integral; Transporter
Mass (Da):
113125
Number AA:
1021
UniProt ID:
P55017
International Prot ID:
IPI00216438
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0015378
PhosphoSite+
KinaseNET
Biological Process:
GO:0006821
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Solute carrier family 12 member 3 pan-specific antibody AB-NN3211#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN3211
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
E
L
P
T
T
E
T
P
G
D
A
T
Site 2
T9
A
E
L
P
T
T
E
T
P
G
D
A
T
L
C
Site 3
T14
T
E
T
P
G
D
A
T
L
C
S
G
R
F
T
Site 4
S17
P
G
D
A
T
L
C
S
G
R
F
T
I
S
T
Site 5
S23
C
S
G
R
F
T
I
S
T
L
L
S
S
D
E
Site 6
T24
S
G
R
F
T
I
S
T
L
L
S
S
D
E
P
Site 7
S27
F
T
I
S
T
L
L
S
S
D
E
P
S
P
P
Site 8
S28
T
I
S
T
L
L
S
S
D
E
P
S
P
P
A
Site 9
S32
L
L
S
S
D
E
P
S
P
P
A
A
Y
D
S
Site 10
Y37
E
P
S
P
P
A
A
Y
D
S
S
H
P
S
H
Site 11
S39
S
P
P
A
A
Y
D
S
S
H
P
S
H
L
T
Site 12
S40
P
P
A
A
Y
D
S
S
H
P
S
H
L
T
H
Site 13
S43
A
Y
D
S
S
H
P
S
H
L
T
H
S
S
T
Site 14
T46
S
S
H
P
S
H
L
T
H
S
S
T
F
C
M
Site 15
S49
P
S
H
L
T
H
S
S
T
F
C
M
R
T
F
Site 16
T50
S
H
L
T
H
S
S
T
F
C
M
R
T
F
G
Site 17
T55
S
S
T
F
C
M
R
T
F
G
Y
N
T
I
D
Site 18
T60
M
R
T
F
G
Y
N
T
I
D
V
V
P
T
Y
Site 19
T66
N
T
I
D
V
V
P
T
Y
E
H
Y
A
N
S
Site 20
Y67
T
I
D
V
V
P
T
Y
E
H
Y
A
N
S
T
Site 21
S73
T
Y
E
H
Y
A
N
S
T
Q
P
G
E
P
R
Site 22
T74
Y
E
H
Y
A
N
S
T
Q
P
G
E
P
R
K
Site 23
T85
E
P
R
K
V
R
P
T
L
A
D
L
H
S
F
Site 24
S91
P
T
L
A
D
L
H
S
F
L
K
Q
E
G
R
Site 25
S107
L
H
A
L
A
F
D
S
R
P
S
H
E
M
T
Site 26
S110
L
A
F
D
S
R
P
S
H
E
M
T
D
G
L
Site 27
T114
S
R
P
S
H
E
M
T
D
G
L
V
E
G
E
Site 28
T124
L
V
E
G
E
A
G
T
S
S
E
K
N
P
E
Site 29
S125
V
E
G
E
A
G
T
S
S
E
K
N
P
E
E
Site 30
S126
E
G
E
A
G
T
S
S
E
K
N
P
E
E
P
Site 31
T194
L
S
I
S
A
I
S
T
N
G
K
V
K
S
G
Site 32
S200
S
T
N
G
K
V
K
S
G
G
T
Y
F
L
I
Site 33
Y204
K
V
K
S
G
G
T
Y
F
L
I
S
R
S
L
Site 34
T241
H
T
V
G
F
A
E
T
V
R
D
L
L
Q
E
Site 35
Y249
V
R
D
L
L
Q
E
Y
G
A
P
I
V
D
P
Site 36
S309
V
G
T
L
I
P
P
S
E
D
K
A
S
K
G
Site 37
S314
P
P
S
E
D
K
A
S
K
G
F
F
S
Y
R
Site 38
S319
K
A
S
K
G
F
F
S
Y
R
A
D
I
F
V
Site 39
Y444
H
Y
G
L
I
N
Y
Y
Q
T
M
S
M
V
S
Site 40
Y499
I
G
F
F
G
K
G
Y
G
K
N
K
E
P
V
Site 41
S555
F
H
A
S
I
T
N
S
P
G
W
R
P
S
F
Site 42
Y564
G
W
R
P
S
F
Q
Y
Y
N
K
W
A
A
L
Site 43
Y605
F
L
L
L
Y
V
I
Y
K
K
P
E
V
N
W
Site 44
S614
K
P
E
V
N
W
G
S
S
V
Q
A
G
S
Y
Site 45
S615
P
E
V
N
W
G
S
S
V
Q
A
G
S
Y
N
Site 46
S620
G
S
S
V
Q
A
G
S
Y
N
L
A
L
S
Y
Site 47
S626
G
S
Y
N
L
A
L
S
Y
S
V
G
L
N
E
Site 48
T649
R
P
Q
C
L
V
L
T
G
P
P
N
F
R
P
Site 49
S710
R
K
I
K
A
F
Y
S
D
V
I
A
E
D
L
Site 50
T753
W
Q
S
A
H
P
A
T
V
E
D
Y
I
G
I
Site 51
Y757
H
P
A
T
V
E
D
Y
I
G
I
L
H
D
A
Site 52
S804
A
E
D
G
K
E
A
S
A
R
V
D
P
K
A
Site 53
T819
L
V
K
E
E
Q
A
T
T
I
F
Q
S
E
Q
Site 54
T820
V
K
E
E
Q
A
T
T
I
F
Q
S
E
Q
G
Site 55
T830
Q
S
E
Q
G
K
K
T
I
D
I
Y
W
L
F
Site 56
Y834
G
K
K
T
I
D
I
Y
W
L
F
D
D
G
G
Site 57
S857
L
G
R
K
R
R
W
S
K
C
K
I
R
V
F
Site 58
S881
Q
E
R
K
A
I
I
S
L
L
S
K
F
R
L
Site 59
T929
D
G
F
K
D
E
A
T
V
N
E
M
R
R
D
Site 60
S942
R
D
C
P
W
K
I
S
D
E
E
I
T
K
N
Site 61
S953
I
T
K
N
R
V
K
S
L
R
Q
V
R
L
N
Site 62
S987
G
R
K
G
K
C
P
S
S
L
Y
M
A
W
L
Site 63
S988
R
K
G
K
C
P
S
S
L
Y
M
A
W
L
E
Site 64
S998
M
A
W
L
E
T
L
S
Q
D
L
R
P
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation