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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Gem
Full Name:
GTP-binding protein GEM
Alias:
GTP binding protein overexpressed in skeletal muscle; GTP-binding mitogen-induced T-cell protein; GTP-binding protein Gem; kinase-inducible Ras-like protein; KIR; Ras-like protein KIR
Type:
G protein, monomeric (non-Rab); G protein
Mass (Da):
33949
Number AA:
296
UniProt ID:
P55040
International Prot ID:
IPI00022710
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009898
Uniprot
OncoNet
Molecular Function:
GO:0019003
GO:0005525
GO:0003924
PhosphoSite+
KinaseNET
Biological Process:
GO:0007166
GO:0006955
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
N
V
T
M
R
Q
G
T
V
G
M
Q
P
Q
Q
Site 2
S23
Q
P
Q
Q
Q
R
W
S
I
P
A
D
G
R
H
Site 3
Y40
V
Q
K
E
P
H
Q
Y
S
H
R
N
R
H
S
Site 4
S41
Q
K
E
P
H
Q
Y
S
H
R
N
R
H
S
A
Site 5
S47
Y
S
H
R
N
R
H
S
A
T
P
E
D
H
C
Site 6
T49
H
R
N
R
H
S
A
T
P
E
D
H
C
R
R
Site 7
S57
P
E
D
H
C
R
R
S
W
S
S
D
S
T
D
Site 8
S59
D
H
C
R
R
S
W
S
S
D
S
T
D
S
V
Site 9
S60
H
C
R
R
S
W
S
S
D
S
T
D
S
V
I
Site 10
S62
R
R
S
W
S
S
D
S
T
D
S
V
I
S
S
Site 11
T63
R
S
W
S
S
D
S
T
D
S
V
I
S
S
E
Site 12
S65
W
S
S
D
S
T
D
S
V
I
S
S
E
S
G
Site 13
S69
S
T
D
S
V
I
S
S
E
S
G
N
T
Y
Y
Site 14
Y75
S
S
E
S
G
N
T
Y
Y
R
V
V
L
I
G
Site 15
Y76
S
E
S
G
N
T
Y
Y
R
V
V
L
I
G
E
Site 16
S104
G
V
H
D
S
M
D
S
D
C
E
V
L
G
E
Site 17
T113
C
E
V
L
G
E
D
T
Y
E
R
T
L
M
V
Site 18
Y114
E
V
L
G
E
D
T
Y
E
R
T
L
M
V
D
Site 19
T160
Y
L
I
V
Y
S
I
T
D
R
A
S
F
E
K
Site 20
S164
Y
S
I
T
D
R
A
S
F
E
K
A
S
E
L
Site 21
T181
Q
L
R
R
A
R
Q
T
E
D
I
P
I
I
L
Site 22
S202
L
V
R
C
R
E
V
S
V
S
E
G
R
A
C
Site 23
S204
R
C
R
E
V
S
V
S
E
G
R
A
C
A
V
Site 24
S245
Q
V
R
L
R
R
D
S
K
E
K
N
E
R
R
Site 25
Y255
K
N
E
R
R
L
A
Y
Q
K
R
K
E
S
M
Site 26
S261
A
Y
Q
K
R
K
E
S
M
P
R
K
A
R
R
Site 27
S287
N
M
A
F
K
L
K
S
K
S
C
H
D
L
S
Site 28
S289
A
F
K
L
K
S
K
S
C
H
D
L
S
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation