PhosphoNET

           
Protein Info 
   
Short Name:  CASP9
Full Name:  Caspase-9
Alias:  APAF-3; Apoptotic protease activating factor 3; Apoptotic protease Mch-6; CASP-9; Caspase 9, apoptosis-related cysteine peptidase; Caspase9; Caspase-9; ICE-LAP6; ICE-like apoptotic protease 6; MCH6; RNCASP9
Type:  Apoptosis; EC 3.4.22.62; Protease
Mass (Da):  46281
Number AA:  416
UniProt ID:  P55211
International Prot ID:  IPI00023875
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829     Uniprot OncoNet
Molecular Function:  GO:0004197  GO:0008047  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0008635  GO:0006508   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S31QLWDALLSRELFRPH
Site 2S48EDIQRAGSGSRRDQA
Site 3S50IQRAGSGSRRDQARQ
Site 4S87TGQDMLASFLRTNRQ
Site 5T91MLASFLRTNRQAAKL
Site 6S99NRQAAKLSKPTLENL
Site 7T107KPTLENLTPVVLRPE
Site 8T125PEVLRPETPRPVDIG
Site 9S133PRPVDIGSGGFGDVG
Site 10S144GDVGALESLRGNADL
Site 11Y153RGNADLAYILSMEPC
Site 12S175NVNFCRESGLRTRTG
Site 13T179CRESGLRTRTGSNID
Site 14T181ESGLRTRTGSNIDCE
Site 15S183GLRTRTGSNIDCEKL
Site 16S195EKLRRRFSSLHFMVE
Site 17S196KLRRRFSSLHFMVEV
Site 18S242LSHGCQASHLQFPGA
Site 19S271VNIFNGTSCPSLGGK
Site 20S274FNGTSCPSLGGKPKL
Site 21T301HGFEVASTSPEDESP
Site 22S302GFEVASTSPEDESPG
Site 23S307STSPEDESPGSNPEP
Site 24S310PEDESPGSNPEPDAT
Site 25T317SNPEPDATPFQEGLR
Site 26T325PFQEGLRTFDQLDAI
Site 27S333FDQLDAISSLPTPSD
Site 28S334DQLDAISSLPTPSDI
Site 29S353STFPGFVSWRDPKSG
Site 30S359VSWRDPKSGSWYVET
Site 31S361WRDPKSGSWYVETLD
Site 32Y363DPKSGSWYVETLDDI
Site 33T366SGSWYVETLDDIFEQ
Site 34S377IFEQWAHSEDLQSLL
Site 35S382AHSEDLQSLLLRVAN
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation