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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDAC4
Full Name:
Histone deacetylase 4
Alias:
EC 3.5.1.98; HD4; Histone deacetylase 5; KIAA0288
Type:
Enzyme, hydrolase; Nuclear receptor co-regulator
Mass (Da):
119040
Number AA:
1084
UniProt ID:
P56524
International Prot ID:
IPI00010088
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000118
GO:0017053
Uniprot
OncoNet
Molecular Function:
GO:0004407
GO:0042826
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
GO:0030183
GO:0014898
GO:0006338
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
S
Q
S
H
P
D
G
L
S
G
Site 2
S11
Q
S
H
P
D
G
L
S
G
R
D
Q
P
V
E
Site 3
S58
L
R
L
D
H
Q
F
S
L
P
V
A
E
P
A
Site 4
S164
N
K
E
K
G
K
E
S
A
V
A
S
T
E
V
Site 5
S168
G
K
E
S
A
V
A
S
T
E
V
K
M
K
L
Site 6
Y201
C
I
S
S
D
P
R
Y
W
Y
G
K
T
Q
H
Site 7
Y203
S
S
D
P
R
Y
W
Y
G
K
T
Q
H
S
S
Site 8
S209
W
Y
G
K
T
Q
H
S
S
L
D
Q
S
S
P
Site 9
S210
Y
G
K
T
Q
H
S
S
L
D
Q
S
S
P
P
Site 10
S214
Q
H
S
S
L
D
Q
S
S
P
P
Q
S
G
V
Site 11
S215
H
S
S
L
D
Q
S
S
P
P
Q
S
G
V
S
Site 12
S219
D
Q
S
S
P
P
Q
S
G
V
S
T
S
Y
N
Site 13
S222
S
P
P
Q
S
G
V
S
T
S
Y
N
H
P
V
Site 14
T223
P
P
Q
S
G
V
S
T
S
Y
N
H
P
V
L
Site 15
S224
P
Q
S
G
V
S
T
S
Y
N
H
P
V
L
G
Site 16
Y225
Q
S
G
V
S
T
S
Y
N
H
P
V
L
G
M
Site 17
T244
D
D
F
P
L
R
K
T
A
S
E
P
N
L
K
Site 18
S246
F
P
L
R
K
T
A
S
E
P
N
L
K
L
R
Site 19
S265
Q
K
V
A
E
R
R
S
S
P
L
L
R
R
K
Site 20
S266
K
V
A
E
R
R
S
S
P
L
L
R
R
K
D
Site 21
T278
R
K
D
G
P
V
V
T
A
L
K
K
R
P
L
Site 22
T288
K
K
R
P
L
D
V
T
D
S
A
C
S
S
A
Site 23
S290
R
P
L
D
V
T
D
S
A
C
S
S
A
P
G
Site 24
S293
D
V
T
D
S
A
C
S
S
A
P
G
S
G
P
Site 25
S294
V
T
D
S
A
C
S
S
A
P
G
S
G
P
S
Site 26
S298
A
C
S
S
A
P
G
S
G
P
S
S
P
N
N
Site 27
S301
S
A
P
G
S
G
P
S
S
P
N
N
S
S
G
Site 28
S302
A
P
G
S
G
P
S
S
P
N
N
S
S
G
S
Site 29
S306
G
P
S
S
P
N
N
S
S
G
S
V
S
A
E
Site 30
S307
P
S
S
P
N
N
S
S
G
S
V
S
A
E
N
Site 31
S309
S
P
N
N
S
S
G
S
V
S
A
E
N
G
I
Site 32
S311
N
N
S
S
G
S
V
S
A
E
N
G
I
A
P
Site 33
S339
R
L
V
A
R
E
G
S
A
A
P
L
P
L
Y
Site 34
Y346
S
A
A
P
L
P
L
Y
T
S
P
S
L
P
N
Site 35
S350
L
P
L
Y
T
S
P
S
L
P
N
I
T
L
G
Site 36
T377
Q
Q
D
A
E
R
L
T
L
P
A
L
Q
Q
R
Site 37
S386
P
A
L
Q
Q
R
L
S
L
F
P
G
T
H
L
Site 38
T394
L
F
P
G
T
H
L
T
P
Y
L
S
T
S
P
Site 39
Y396
P
G
T
H
L
T
P
Y
L
S
T
S
P
L
E
Site 40
S398
T
H
L
T
P
Y
L
S
T
S
P
L
E
R
D
Site 41
S400
L
T
P
Y
L
S
T
S
P
L
E
R
D
G
G
Site 42
S411
R
D
G
G
A
A
H
S
P
L
L
Q
H
M
V
Site 43
S450
L
V
G
A
D
R
V
S
P
S
I
H
K
L
R
Site 44
S452
G
A
D
R
V
S
P
S
I
H
K
L
R
Q
H
Site 45
T465
Q
H
R
P
L
G
R
T
Q
S
A
P
L
P
Q
Site 46
S467
R
P
L
G
R
T
Q
S
A
P
L
P
Q
N
A
Site 47
S520
E
P
A
R
Q
P
E
S
H
P
E
E
T
E
E
Site 48
Y540
Q
A
L
L
D
E
P
Y
L
D
R
L
P
G
Q
Site 49
S565
V
K
Q
E
P
I
E
S
D
E
E
E
A
E
P
Site 50
S584
E
P
G
Q
R
Q
P
S
E
Q
E
L
L
F
R
Site 51
Y608
R
I
H
Q
L
R
N
Y
Q
A
S
M
E
A
A
Site 52
S611
Q
L
R
N
Y
Q
A
S
M
E
A
A
G
I
P
Site 53
S628
F
G
G
H
R
P
L
S
R
A
Q
S
S
P
A
Site 54
S632
R
P
L
S
R
A
Q
S
S
P
A
S
A
T
F
Site 55
S633
P
L
S
R
A
Q
S
S
P
A
S
A
T
F
P
Site 56
S636
R
A
Q
S
S
P
A
S
A
T
F
P
V
S
V
Site 57
T638
Q
S
S
P
A
S
A
T
F
P
V
S
V
Q
E
Site 58
S642
A
S
A
T
F
P
V
S
V
Q
E
P
P
T
K
Site 59
T648
V
S
V
Q
E
P
P
T
K
P
R
F
T
T
G
Site 60
T653
P
P
T
K
P
R
F
T
T
G
L
V
Y
D
T
Site 61
T654
P
T
K
P
R
F
T
T
G
L
V
Y
D
T
L
Site 62
Y658
R
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Site 63
T668
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
Site 64
S671
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
Site 65
S673
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
Site 66
S674
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
Site 67
S684
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
Site 68
T707
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
Site 69
T713
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
Site 70
S716
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
Site 71
T720
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
Site 72
Y723
S
E
A
H
T
L
L
Y
G
T
N
P
L
N
R
Site 73
S735
L
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
Site 74
S741
D
S
K
K
L
L
G
S
L
A
S
V
F
V
R
Site 75
S758
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
Site 76
T760
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
Site 77
T808
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
Site 78
Y852
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
Site 79
S853
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
Site 80
S856
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
Site 81
Y859
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
Site 82
S861
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
Site 83
Y865
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
Site 84
S874
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
Site 85
T941
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
Site 86
T979
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
Site 87
S1025
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
Site 88
T1034
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
Site 89
T1035
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
Site 90
S1036
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
Site 91
T1037
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
Site 92
T1055
C
E
N
E
E
A
E
T
V
T
A
M
A
S
L
Site 93
T1057
N
E
E
A
E
T
V
T
A
M
A
S
L
S
V
Site 94
S1061
E
T
V
T
A
M
A
S
L
S
V
G
V
K
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation