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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
eIF6
Full Name:
Eukaryotic translation initiation factor 6
Alias:
B(2)gcn; B(2)GCN homolog; B4 integrin interactor; CAB; EIF3A; EIF-6; IF6; ITGB4BP; P27(BBP); P27BBP
Type:
Protein synthesis protein
Mass (Da):
26599
Number AA:
245
UniProt ID:
P56537
International Prot ID:
IPI00010105
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0043022
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0042256
GO:0006412
GO:0009058
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y35
I
G
G
S
E
N
F
Y
S
V
F
E
G
E
L
Site 2
S36
G
G
S
E
N
F
Y
S
V
F
E
G
E
L
S
Site 3
S87
E
L
Q
H
I
R
N
S
L
P
D
T
V
Q
I
Site 4
T91
I
R
N
S
L
P
D
T
V
Q
I
R
R
V
E
Site 5
S102
R
R
V
E
E
R
L
S
A
L
G
N
V
T
T
Site 6
Y113
N
V
T
T
C
N
D
Y
V
A
L
V
H
P
D
Site 7
T125
H
P
D
L
D
R
E
T
E
E
I
L
A
D
V
Site 8
T165
G
G
L
V
H
P
K
T
S
I
E
D
Q
D
E
Site 9
S174
I
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
Site 10
S175
E
D
Q
D
E
L
S
S
L
L
Q
V
P
L
V
Site 11
S216
D
T
T
S
T
E
L
S
V
V
E
S
V
F
K
Site 12
S230
K
L
N
E
A
Q
P
S
T
I
A
T
S
M
R
Site 13
T231
L
N
E
A
Q
P
S
T
I
A
T
S
M
R
D
Site 14
T234
A
Q
P
S
T
I
A
T
S
M
R
D
S
L
I
Site 15
S235
Q
P
S
T
I
A
T
S
M
R
D
S
L
I
D
Site 16
S239
I
A
T
S
M
R
D
S
L
I
D
S
L
T
_
Site 17
S243
M
R
D
S
L
I
D
S
L
T
_
_
_
_
_
Site 18
T245
D
S
L
I
D
S
L
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation