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Updated November 2019
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Protein Info
Short Name:
SIK
Full Name:
Serine/threonine-protein kinase SIK1
Alias:
EC 2.7.11.1; Msk; Myocardial SNF1-like kinase; Salt-inducible kinase; Salt-inducible kinase 1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK; SN1L1; SNF1-like kinase; SNF1LK
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CAMK group; CAMKL family; QIK subfamily
Mass (Da):
84902
Number AA:
783
UniProt ID:
P57059
International Prot ID:
IPI00784427
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0030154
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Salt-inducible serine/threonine-protein kinase SIK1; Serine-threonine-protein kinase SNF1-like kinase 1 pan-specific antibody AB-NK251-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK251-1#Salt-inducible serine/threonine-protein kinase SIK1; Serine-threonine-protein kinase SNF1-like kinase 1 pan-specific antibody AB-NK251-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK251-2#Salt-inducible serine/threonine-protein kinase SIK1; Serine-threonine-protein kinase SNF1-like kinase 1 pan-specific antibody AB-NK251-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK251-3#Salt-inducible serine/threonine-protein kinase SIK1; Serine-threonine-protein kinase SNF1-like kinase 1 T182 phosphosite-specific antibody AB-PK812#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK812#AMPK/SIK KinSub - AMPK/SIK peptide substrate AMARAASAAALARRR - Powder PE-01ACL95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACL95#Salt-inducible serine/threonine-protein kinase SIK1 / Serine-threonine-protein kinase SNF1-like kinase 1 (M1-G15, human) peptide - Powder PE-01AYV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AYV99#Salt-inducible serine/threonine-protein kinase SIK1 / Serine-threonine-protein kinase SNF1-like kinase 1 (A264-M278, human) peptide - Powder PE-01AYW99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AYW99#Salt-inducible serine/threonine-protein kinase SIK1 / Serine-threonine-protein kinase SNF1-like kinase 1 (E769-Q783, human) peptide - Powder PE-01AYX70#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AYX70#Salt-inducible serine/threonine-protein kinase SIK1 / Serine-threonine-protein kinase SNF1-like kinase 1 (P179-G185, human) pT182 phosphopeptide - Powder PE-04APP99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APP99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y27
K
P
L
R
V
G
F
Y
D
I
E
R
T
L
G
Site 2
T49
K
L
A
R
H
R
V
T
K
T
Q
V
A
I
K
Site 3
T61
A
I
K
I
I
D
K
T
R
L
D
S
S
N
L
Site 4
S65
I
D
K
T
R
L
D
S
S
N
L
E
K
I
Y
Site 5
Y72
S
S
N
L
E
K
I
Y
R
E
V
Q
L
M
K
Site 6
Y90
H
P
H
I
I
K
L
Y
Q
V
M
E
T
K
D
Site 7
Y100
M
E
T
K
D
M
L
Y
I
V
T
E
F
A
K
Site 8
Y114
K
N
G
E
M
F
D
Y
L
T
S
N
G
H
L
Site 9
T116
G
E
M
F
D
Y
L
T
S
N
G
H
L
S
E
Site 10
T152
I
V
H
R
D
L
K
T
E
N
L
L
L
D
G
Site 11
Y174
D
F
G
F
G
N
F
Y
K
S
G
E
P
L
S
Site 12
S176
G
F
G
N
F
Y
K
S
G
E
P
L
S
T
W
Site 13
S181
Y
K
S
G
E
P
L
S
T
W
C
G
S
P
P
Site 14
T182
K
S
G
E
P
L
S
T
W
C
G
S
P
P
Y
Salt-inducible serine/threonine-protein kinase SIK1; Serine-threonine-protein kinase SNF1-like kinase 1 T182 phosphosite-specific antibody AB-PK812#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK812#Salt-inducible serine/threonine-protein kinase SIK1 / Serine-threonine-protein kinase SNF1-like kinase 1 (P179-G185, human) pT182 phosphopeptide - Powder PE-04APP99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APP99
Site 15
S186
P
L
S
T
W
C
G
S
P
P
Y
A
A
P
E
Site 16
Y189
T
W
C
G
S
P
P
Y
A
A
P
E
V
F
E
Site 17
Y200
E
V
F
E
G
K
E
Y
E
G
P
Q
L
D
I
Site 18
T231
F
D
G
P
N
L
P
T
L
R
Q
R
V
L
E
Site 19
T268
V
D
P
A
R
R
I
T
I
A
Q
I
R
Q
H
Site 20
S293
G
P
A
C
P
A
F
S
A
H
S
Y
T
S
N
Site 21
S296
C
P
A
F
S
A
H
S
Y
T
S
N
L
G
D
Site 22
Y297
P
A
F
S
A
H
S
Y
T
S
N
L
G
D
Y
Site 23
Y304
Y
T
S
N
L
G
D
Y
D
E
Q
A
L
G
I
Site 24
T322
L
G
V
D
R
Q
R
T
V
E
S
L
Q
N
S
Site 25
S325
D
R
Q
R
T
V
E
S
L
Q
N
S
S
Y
N
Site 26
S329
T
V
E
S
L
Q
N
S
S
Y
N
H
F
A
A
Site 27
Y331
E
S
L
Q
N
S
S
Y
N
H
F
A
A
I
Y
Site 28
S366
A
R
Q
P
R
P
R
S
S
D
L
S
G
L
E
Site 29
S367
R
Q
P
R
P
R
S
S
D
L
S
G
L
E
V
Site 30
S370
R
P
R
S
S
D
L
S
G
L
E
V
P
Q
E
Site 31
S380
E
V
P
Q
E
G
L
S
T
D
P
F
R
P
A
Site 32
T381
V
P
Q
E
G
L
S
T
D
P
F
R
P
A
L
Site 33
S399
Q
P
Q
T
L
V
Q
S
V
L
Q
A
E
M
D
Site 34
S435
V
F
R
P
R
P
V
S
P
S
S
L
L
D
T
Site 35
S437
R
P
R
P
V
S
P
S
S
L
L
D
T
A
I
Site 36
S438
P
R
P
V
S
P
S
S
L
L
D
T
A
I
S
Site 37
T442
S
P
S
S
L
L
D
T
A
I
S
E
E
A
R
Site 38
T460
G
L
E
E
E
Q
D
T
Q
E
S
L
P
S
S
Site 39
S463
E
E
Q
D
T
Q
E
S
L
P
S
S
T
G
R
Site 40
S466
D
T
Q
E
S
L
P
S
S
T
G
R
R
H
T
Site 41
S467
T
Q
E
S
L
P
S
S
T
G
R
R
H
T
L
Site 42
T468
Q
E
S
L
P
S
S
T
G
R
R
H
T
L
A
Site 43
T473
S
S
T
G
R
R
H
T
L
A
E
V
S
T
R
Site 44
S478
R
H
T
L
A
E
V
S
T
R
L
S
P
L
T
Site 45
T479
H
T
L
A
E
V
S
T
R
L
S
P
L
T
A
Site 46
S498
V
S
P
S
T
T
A
S
P
A
E
G
T
S
S
Site 47
S504
A
S
P
A
E
G
T
S
S
D
S
C
L
T
F
Site 48
S505
S
P
A
E
G
T
S
S
D
S
C
L
T
F
S
Site 49
S507
A
E
G
T
S
S
D
S
C
L
T
F
S
A
S
Site 50
T510
T
S
S
D
S
C
L
T
F
S
A
S
K
S
P
Site 51
S512
S
D
S
C
L
T
F
S
A
S
K
S
P
A
G
Site 52
S516
L
T
F
S
A
S
K
S
P
A
G
L
S
G
T
Site 53
S521
S
K
S
P
A
G
L
S
G
T
P
A
T
Q
G
Site 54
S575
F
Q
E
G
R
R
A
S
D
T
S
L
T
Q
G
Site 55
T577
E
G
R
R
A
S
D
T
S
L
T
Q
G
L
K
Site 56
S578
G
R
R
A
S
D
T
S
L
T
Q
G
L
K
A
Site 57
T593
F
R
Q
Q
L
R
K
T
T
R
T
K
G
F
L
Site 58
T594
R
Q
Q
L
R
K
T
T
R
T
K
G
F
L
G
Site 59
T596
Q
L
R
K
T
T
R
T
K
G
F
L
G
L
N
Site 60
S618
Q
V
C
Q
A
P
A
S
R
A
S
R
G
G
L
Site 61
S621
Q
A
P
A
S
R
A
S
R
G
G
L
S
P
F
Site 62
S626
R
A
S
R
G
G
L
S
P
F
H
A
P
A
Q
Site 63
S634
P
F
H
A
P
A
Q
S
P
G
L
H
G
G
A
Site 64
S644
L
H
G
G
A
A
G
S
R
E
G
W
S
L
L
Site 65
S649
A
G
S
R
E
G
W
S
L
L
E
E
V
L
E
Site 66
S674
P
A
A
A
P
G
C
S
Q
A
P
Q
P
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation