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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Grb2
Full Name:
Growth factor receptor-bound protein 2
Alias:
ASH; GRB2 adapter protein; NCKAP2; SH2/SH3 adapter GRB2
Type:
Adapter/scaffold protein
Mass (Da):
25206
Number AA:
217
UniProt ID:
P62993
International Prot ID:
IPI00021327
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005070
GO:0005154
GO:0043560
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0007267
GO:0007173
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
E
A
I
A
K
Y
D
F
K
A
T
A
D
Site 2
S18
A
T
A
D
D
E
L
S
F
K
R
G
D
I
L
Site 3
Y37
E
E
C
D
Q
N
W
Y
K
A
E
L
N
G
K
Site 4
Y52
D
G
F
I
P
K
N
Y
I
E
M
K
P
H
P
Site 5
S75
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
Site 6
S88
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
Site 7
S96
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
Site 8
S98
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Site 9
Y134
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
Site 10
S137
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Site 11
T138
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
Site 12
S139
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
Site 13
S141
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
Site 14
T159
E
Q
V
P
Q
Q
P
T
Y
V
Q
A
L
F
D
Site 15
Y160
Q
V
P
Q
Q
P
T
Y
V
Q
A
L
F
D
F
Site 16
Y209
T
G
M
F
P
R
N
Y
V
T
P
V
N
R
N
Site 17
T211
M
F
P
R
N
Y
V
T
P
V
N
R
N
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation