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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
14-3-3 zeta
Full Name:
14-3-3 protein zeta/delta
Alias:
1433Z; 14-3-3-zeta; 143Z; Factor activating exoenzyme S; FAS; KCIP-1; Mitochondrial import stimulation factor S1 subunit; Protein kinase C inhibitor protein-1; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; YWHAZ
Type:
Adapter/scaffold protein, 14-3-3 family
Mass (Da):
27745
Number AA:
245
UniProt ID:
P63104
International Prot ID:
IPI00021263
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
Site 2
S28
D
M
A
A
C
M
K
S
V
T
E
Q
G
A
E
Site 3
S37
T
E
Q
G
A
E
L
S
N
E
E
R
N
L
L
Site 4
S45
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
Site 5
Y48
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
Site 6
S57
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
Site 7
S58
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
Site 8
S63
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
E
Site 9
S64
S
S
W
R
V
V
S
S
I
E
Q
K
T
E
G
Site 10
Y82
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
Site 11
T88
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
Site 12
S99
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
Site 13
S110
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Site 14
S114
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
Site 15
Y118
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Site 16
Y125
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
Site 17
Y126
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
Site 18
Y128
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
Site 19
S145
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
Site 20
Y149
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
Site 21
T163
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
Site 22
Y178
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
Site 23
Y179
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
Site 24
S184
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
Site 25
S190
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
Site 26
T194
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
Site 27
T205
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
Site 28
S207
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
Site 29
S210
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
Site 30
Y211
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Site 31
S214
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
Site 32
T215
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
Site 33
T226
Q
L
L
R
D
N
L
T
L
W
T
S
D
T
Q
Site 34
T229
R
D
N
L
T
L
W
T
S
D
T
Q
G
D
E
Site 35
S230
D
N
L
T
L
W
T
S
D
T
Q
G
D
E
A
Site 36
T232
L
T
L
W
T
S
D
T
Q
G
D
E
A
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation