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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACTG1
Full Name:
Actin, cytoplasmic 2
Alias:
ACTG; Actin, gamma 1; Gamma-actin
Type:
Cytoskeleton protein. Actin family.
Mass (Da):
41793
Number AA:
375
UniProt ID:
P63261
International Prot ID:
IPI00021440
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0006928
GO:0007605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
A
P
R
A
V
F
P
S
I
V
G
R
P
R
H
Site 2
S52
V
G
M
G
Q
K
D
S
Y
V
G
D
E
A
Q
Site 3
Y53
G
M
G
Q
K
D
S
Y
V
G
D
E
A
Q
S
Site 4
S60
Y
V
G
D
E
A
Q
S
K
R
G
I
L
T
L
Site 5
T66
Q
S
K
R
G
I
L
T
L
K
Y
P
I
E
H
Site 6
Y69
R
G
I
L
T
L
K
Y
P
I
E
H
G
I
V
Site 7
T89
M
E
K
I
W
H
H
T
F
Y
N
E
L
R
V
Site 8
Y91
K
I
W
H
H
T
F
Y
N
E
L
R
V
A
P
Site 9
T106
E
E
H
P
V
L
L
T
E
A
P
L
N
P
K
Site 10
T120
K
A
N
R
E
K
M
T
Q
I
M
F
E
T
F
Site 11
Y143
I
Q
A
V
L
S
L
Y
A
S
G
R
T
T
G
Site 12
S155
T
T
G
I
V
M
D
S
G
D
G
V
T
H
T
Site 13
T162
S
G
D
G
V
T
H
T
V
P
I
Y
E
G
Y
Site 14
Y166
V
T
H
T
V
P
I
Y
E
G
Y
A
L
P
H
Site 15
Y169
T
V
P
I
Y
E
G
Y
A
L
P
H
A
I
L
Site 16
Y188
A
G
R
D
L
T
D
Y
L
M
K
I
L
T
E
Site 17
T194
D
Y
L
M
K
I
L
T
E
R
G
Y
S
F
T
Site 18
Y198
K
I
L
T
E
R
G
Y
S
F
T
T
T
A
E
Site 19
S199
I
L
T
E
R
G
Y
S
F
T
T
T
A
E
R
Site 20
T201
T
E
R
G
Y
S
F
T
T
T
A
E
R
E
I
Site 21
T202
E
R
G
Y
S
F
T
T
T
A
E
R
E
I
V
Site 22
T203
R
G
Y
S
F
T
T
T
A
E
R
E
I
V
R
Site 23
Y218
D
I
K
E
K
L
C
Y
V
A
L
D
F
E
Q
Site 24
T229
D
F
E
Q
E
M
A
T
A
A
S
S
S
S
L
Site 25
S232
Q
E
M
A
T
A
A
S
S
S
S
L
E
K
S
Site 26
S233
E
M
A
T
A
A
S
S
S
S
L
E
K
S
Y
Site 27
S235
A
T
A
A
S
S
S
S
L
E
K
S
Y
E
L
Site 28
S239
S
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
Site 29
Y240
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Site 30
T249
L
P
D
G
Q
V
I
T
I
G
N
E
R
F
R
Site 31
S265
P
E
A
L
F
Q
P
S
F
L
G
M
E
S
C
Site 32
S271
P
S
F
L
G
M
E
S
C
G
I
H
E
T
T
Site 33
T278
S
C
G
I
H
E
T
T
F
N
S
I
M
K
C
Site 34
Y294
V
D
I
R
K
D
L
Y
A
N
T
V
L
S
G
Site 35
T297
R
K
D
L
Y
A
N
T
V
L
S
G
G
T
T
Site 36
S300
L
Y
A
N
T
V
L
S
G
G
T
T
M
Y
P
Site 37
T303
N
T
V
L
S
G
G
T
T
M
Y
P
G
I
A
Site 38
T304
T
V
L
S
G
G
T
T
M
Y
P
G
I
A
D
Site 39
Y306
L
S
G
G
T
T
M
Y
P
G
I
A
D
R
M
Site 40
T318
D
R
M
Q
K
E
I
T
A
L
A
P
S
T
M
Site 41
S323
E
I
T
A
L
A
P
S
T
M
K
I
K
I
I
Site 42
Y337
I
A
P
P
E
R
K
Y
S
V
W
I
G
G
S
Site 43
S338
A
P
P
E
R
K
Y
S
V
W
I
G
G
S
I
Site 44
Y362
M
W
I
S
K
Q
E
Y
D
E
S
G
P
S
I
Site 45
S365
S
K
Q
E
Y
D
E
S
G
P
S
I
V
H
R
Site 46
S368
E
Y
D
E
S
G
P
S
I
V
H
R
K
C
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation