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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF2I
Full Name:
General transcription factor II-I
Alias:
BAP135; BAP-135; Bruton tyrosine kinase-associated protein-135; BTKAP1; BTK-associated protein 135; BTK-associated protein-135; DIWS; DIWS1T; General II-I; General transcription factor IIi; GTFI; GTFII-I; IB291; SPIN; SRF-Phox1 interacting protein; WBSCR6; Williams-Beuren syndrome chromosome region 6 protein
Type:
Transcription, coactivator/corepressor
Mass (Da):
112416
Number AA:
998
UniProt ID:
P78347
International Prot ID:
IPI00054042
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0016251
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0007165
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
P
V
E
D
E
E
S
S
E
S
R
M
V
V
Site 2
S19
E
D
E
E
S
S
E
S
R
M
V
V
T
F
L
Site 3
T68
R
G
R
A
F
V
N
T
R
K
D
F
Q
K
D
Site 4
Y79
F
Q
K
D
F
V
K
Y
C
V
E
E
E
E
K
Site 5
S103
T
T
Q
A
N
R
M
S
V
D
A
V
E
I
E
Site 6
T115
E
I
E
T
L
R
K
T
V
E
D
Y
F
C
F
Site 7
Y119
L
R
K
T
V
E
D
Y
F
C
F
C
Y
G
K
Site 8
Y124
E
D
Y
F
C
F
C
Y
G
K
A
L
G
K
S
Site 9
T132
G
K
A
L
G
K
S
T
V
V
P
V
P
Y
E
Site 10
S146
E
K
M
L
R
D
Q
S
A
V
V
V
Q
G
L
Site 11
T169
P
E
N
Y
D
L
A
T
L
K
W
I
L
E
N
Site 12
T202
V
G
G
R
V
M
V
T
D
A
D
R
S
I
L
Site 13
S207
M
V
T
D
A
D
R
S
I
L
S
P
G
G
S
Site 14
S210
D
A
D
R
S
I
L
S
P
G
G
S
C
G
P
Site 15
S214
S
I
L
S
P
G
G
S
C
G
P
I
K
V
K
Site 16
T222
C
G
P
I
K
V
K
T
E
P
T
E
D
S
G
Site 17
S228
K
T
E
P
T
E
D
S
G
I
S
L
E
M
A
Site 18
T238
S
L
E
M
A
A
V
T
V
K
E
E
S
E
D
Site 19
Y248
E
E
S
E
D
P
D
Y
Y
Q
Y
N
I
Q
A
Site 20
Y249
E
S
E
D
P
D
Y
Y
Q
Y
N
I
Q
A
G
Site 21
Y251
E
D
P
D
Y
Y
Q
Y
N
I
Q
A
G
P
S
Site 22
S270
V
D
E
K
Q
P
L
S
K
P
L
Q
G
S
H
Site 23
S276
L
S
K
P
L
Q
G
S
H
H
S
S
E
G
N
Site 24
S280
L
Q
G
S
H
H
S
S
E
G
N
E
G
T
E
Site 25
S295
M
E
V
P
A
E
D
S
T
Q
H
V
P
S
E
Site 26
T296
E
V
P
A
E
D
S
T
Q
H
V
P
S
E
T
Site 27
S301
D
S
T
Q
H
V
P
S
E
T
S
E
D
P
E
Site 28
S304
Q
H
V
P
S
E
T
S
E
D
P
E
V
E
V
Site 29
T312
E
D
P
E
V
E
V
T
I
E
D
D
D
Y
S
Site 30
Y318
V
T
I
E
D
D
D
Y
S
P
P
S
K
R
P
Site 31
S319
T
I
E
D
D
D
Y
S
P
P
S
K
R
P
K
Site 32
S322
D
D
D
Y
S
P
P
S
K
R
P
K
A
N
E
Site 33
T359
E
K
W
N
A
R
I
T
D
L
R
K
Q
V
E
Site 34
Y373
E
E
L
F
E
R
K
Y
A
Q
A
I
K
A
K
Site 35
Y387
K
G
P
V
T
I
P
Y
P
L
F
Q
S
H
V
Site 36
Y398
Q
S
H
V
E
D
L
Y
V
E
G
L
P
E
G
Site 37
S412
G
I
P
F
R
R
P
S
T
Y
G
I
P
R
L
Site 38
T413
I
P
F
R
R
P
S
T
Y
G
I
P
R
L
E
Site 39
Y414
P
F
R
R
P
S
T
Y
G
I
P
R
L
E
R
Site 40
S441
K
K
H
E
L
L
N
S
T
R
E
D
L
Q
L
Site 41
S453
L
Q
L
D
K
P
A
S
G
V
K
E
E
W
Y
Site 42
Y460
S
G
V
K
E
E
W
Y
A
R
I
T
K
L
R
Site 43
S484
K
F
A
E
A
L
G
S
T
E
A
K
A
V
P
Site 44
Y503
E
A
H
P
N
D
L
Y
V
E
G
L
P
E
N
Site 45
S515
P
E
N
I
P
F
R
S
P
S
W
Y
G
I
P
Site 46
S517
N
I
P
F
R
S
P
S
W
Y
G
I
P
R
L
Site 47
Y519
P
F
R
S
P
S
W
Y
G
I
P
R
L
E
K
Site 48
T545
I
K
R
P
E
L
L
T
H
S
T
T
E
V
T
Site 49
S547
R
P
E
L
L
T
H
S
T
T
E
V
T
Q
P
Site 50
T549
E
L
L
T
H
S
T
T
E
V
T
Q
P
R
T
Site 51
T556
T
E
V
T
Q
P
R
T
N
T
P
V
K
E
D
Site 52
T558
V
T
Q
P
R
T
N
T
P
V
K
E
D
W
N
Site 53
T569
E
D
W
N
V
R
I
T
K
L
R
K
Q
V
E
Site 54
Y597
T
E
A
V
K
V
P
Y
P
V
F
E
S
N
P
Site 55
Y608
E
S
N
P
E
F
L
Y
V
E
G
L
P
E
G
Site 56
S620
P
E
G
I
P
F
R
S
P
T
W
F
G
I
P
Site 57
T663
G
M
A
S
K
I
N
T
K
A
L
Q
S
P
K
Site 58
S668
I
N
T
K
A
L
Q
S
P
K
R
P
R
S
P
Site 59
S674
Q
S
P
K
R
P
R
S
P
G
S
N
S
K
V
Site 60
S677
K
R
P
R
S
P
G
S
N
S
K
V
P
E
I
Site 61
S679
P
R
S
P
G
S
N
S
K
V
P
E
I
E
V
Site 62
T687
K
V
P
E
I
E
V
T
V
E
G
P
N
N
N
Site 63
T698
P
N
N
N
N
P
Q
T
S
A
V
R
T
P
T
Site 64
S699
N
N
N
N
P
Q
T
S
A
V
R
T
P
T
Q
Site 65
T703
P
Q
T
S
A
V
R
T
P
T
Q
T
N
G
S
Site 66
T705
T
S
A
V
R
T
P
T
Q
T
N
G
S
N
V
Site 67
T707
A
V
R
T
P
T
Q
T
N
G
S
N
V
P
F
Site 68
S710
T
P
T
Q
T
N
G
S
N
V
P
F
K
P
R
Site 69
S722
K
P
R
G
R
E
F
S
F
E
A
W
N
A
K
Site 70
Y770
E
S
F
P
E
D
F
Y
V
E
G
L
P
E
G
Site 71
S784
G
V
P
F
R
R
P
S
T
F
G
I
P
R
L
Site 72
T785
V
P
F
R
R
P
S
T
F
G
I
P
R
L
E
Site 73
T813
K
K
P
E
M
F
E
T
A
I
K
E
S
T
S
Site 74
S818
F
E
T
A
I
K
E
S
T
S
S
K
S
P
P
Site 75
T819
E
T
A
I
K
E
S
T
S
S
K
S
P
P
R
Site 76
S820
T
A
I
K
E
S
T
S
S
K
S
P
P
R
K
Site 77
S821
A
I
K
E
S
T
S
S
K
S
P
P
R
K
I
Site 78
S823
K
E
S
T
S
S
K
S
P
P
R
K
I
N
S
Site 79
S830
S
P
P
R
K
I
N
S
S
P
N
V
N
T
T
Site 80
S831
P
P
R
K
I
N
S
S
P
N
V
N
T
T
A
Site 81
T836
N
S
S
P
N
V
N
T
T
A
S
G
V
E
D
Site 82
T837
S
S
P
N
V
N
T
T
A
S
G
V
E
D
L
Site 83
S839
P
N
V
N
T
T
A
S
G
V
E
D
L
N
I
Site 84
T850
D
L
N
I
I
Q
V
T
I
P
D
D
D
N
E
Site 85
S860
D
D
D
N
E
R
L
S
K
V
E
K
A
R
Q
Site 86
S877
E
Q
V
N
D
L
F
S
R
K
F
G
E
A
I
Site 87
S914
D
G
M
P
P
G
V
S
F
K
A
P
S
Y
L
Site 88
Y920
V
S
F
K
A
P
S
Y
L
E
I
S
S
M
R
Site 89
S924
A
P
S
Y
L
E
I
S
S
M
R
R
I
L
D
Site 90
S925
P
S
Y
L
E
I
S
S
M
R
R
I
L
D
S
Site 91
S932
S
M
R
R
I
L
D
S
A
E
F
I
K
F
T
Site 92
S957
N
N
Q
L
V
D
Q
S
E
S
E
G
P
V
I
Site 93
S959
Q
L
V
D
Q
S
E
S
E
G
P
V
I
Q
E
Site 94
S967
E
G
P
V
I
Q
E
S
A
E
P
S
Q
L
E
Site 95
S971
I
Q
E
S
A
E
P
S
Q
L
E
V
P
A
T
Site 96
T978
S
Q
L
E
V
P
A
T
E
E
I
K
E
T
D
Site 97
T984
A
T
E
E
I
K
E
T
D
G
S
S
Q
I
K
Site 98
S987
E
I
K
E
T
D
G
S
S
Q
I
K
Q
E
P
Site 99
S988
I
K
E
T
D
G
S
S
Q
I
K
Q
E
P
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation