KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DLG4
Full Name:
Disks large homolog 4
Alias:
Discs large 4; Discs, large 4; Postsynaptic density 95; Postsynaptic density protein 95; Presynaptic density protein 95; PSD95; SAP90; SAP-90; Synapse-associated protein 90
Type:
Adapter/scaffold protein
Mass (Da):
80495
Number AA:
724
UniProt ID:
P78352
International Prot ID:
IPI00619928
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0030863
GO:0030666
Uniprot
OncoNet
Molecular Function:
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0007612
GO:0007399
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Disks large homologue 4 pan-specific antibody AB-NN142#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN142#Disks large homologue 4 pan-specific antibody AB-NN142-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN142-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
D
C
L
C
I
V
T
T
K
K
Y
R
Y
Q
Site 2
Y12
C
I
V
T
T
K
K
Y
R
Y
Q
D
E
D
T
Site 3
Y14
V
T
T
K
K
Y
R
Y
Q
D
E
D
T
P
P
Site 4
T19
Y
R
Y
Q
D
E
D
T
P
P
L
E
H
S
P
Site 5
S25
D
T
P
P
L
E
H
S
P
A
H
L
P
N
Q
Site 6
S35
H
L
P
N
Q
A
N
S
P
P
V
I
V
N
T
Site 7
T44
P
V
I
V
N
T
D
T
L
E
A
P
G
Y
E
Site 8
Y50
D
T
L
E
A
P
G
Y
E
L
Q
V
N
G
T
Site 9
Y63
G
T
E
G
E
M
E
Y
E
E
I
T
L
E
R
Site 10
T67
E
M
E
Y
E
E
I
T
L
E
R
G
N
S
G
Site 11
S73
I
T
L
E
R
G
N
S
G
L
G
F
S
I
A
Site 12
S78
G
N
S
G
L
G
F
S
I
A
G
G
T
D
N
Site 13
T83
G
F
S
I
A
G
G
T
D
N
P
H
I
G
D
Site 14
S116
G
R
L
R
V
N
D
S
I
L
F
V
N
E
V
Site 15
T129
E
V
D
V
R
E
V
T
H
S
A
A
V
E
A
Site 16
S131
D
V
R
E
V
T
H
S
A
A
V
E
A
L
K
Site 17
S142
E
A
L
K
E
A
G
S
I
V
R
L
Y
V
M
Site 18
Y147
A
G
S
I
V
R
L
Y
V
M
R
R
K
P
P
Site 19
Y190
I
P
G
D
N
S
I
Y
V
T
K
I
I
E
G
Site 20
T192
G
D
N
S
I
Y
V
T
K
I
I
E
G
G
A
Site 21
Y236
V
A
A
L
K
N
T
Y
D
V
V
Y
L
K
V
Site 22
Y240
K
N
T
Y
D
V
V
Y
L
K
V
A
K
P
S
Site 23
Y250
V
A
K
P
S
N
A
Y
L
S
D
S
Y
A
P
Site 24
S252
K
P
S
N
A
Y
L
S
D
S
Y
A
P
P
D
Site 25
S254
S
N
A
Y
L
S
D
S
Y
A
P
P
D
I
T
Site 26
Y255
N
A
Y
L
S
D
S
Y
A
P
P
D
I
T
T
Site 27
T261
S
Y
A
P
P
D
I
T
T
S
Y
S
Q
H
L
Site 28
S263
A
P
P
D
I
T
T
S
Y
S
Q
H
L
D
N
Site 29
S265
P
D
I
T
T
S
Y
S
Q
H
L
D
N
E
I
Site 30
S273
Q
H
L
D
N
E
I
S
H
S
S
Y
L
G
T
Site 31
S275
L
D
N
E
I
S
H
S
S
Y
L
G
T
D
Y
Site 32
Y277
N
E
I
S
H
S
S
Y
L
G
T
D
Y
P
T
Site 33
T280
S
H
S
S
Y
L
G
T
D
Y
P
T
A
M
T
Site 34
Y282
S
S
Y
L
G
T
D
Y
P
T
A
M
T
P
T
Site 35
T287
T
D
Y
P
T
A
M
T
P
T
S
P
R
R
Y
Site 36
S290
P
T
A
M
T
P
T
S
P
R
R
Y
S
P
V
Site 37
Y294
T
P
T
S
P
R
R
Y
S
P
V
A
K
D
L
Site 38
S295
P
T
S
P
R
R
Y
S
P
V
A
K
D
L
L
Site 39
S350
A
G
G
P
A
D
L
S
G
E
L
R
K
G
D
Site 40
S361
R
K
G
D
Q
I
L
S
V
N
G
V
D
L
R
Site 41
S371
G
V
D
L
R
N
A
S
H
E
Q
A
A
I
A
Site 42
Y397
A
Q
Y
K
P
E
E
Y
S
R
F
E
A
K
I
Site 43
S414
L
R
E
Q
L
M
N
S
S
L
G
S
G
T
A
Site 44
S415
R
E
Q
L
M
N
S
S
L
G
S
G
T
A
S
Site 45
S418
L
M
N
S
S
L
G
S
G
T
A
S
L
R
S
Site 46
T420
N
S
S
L
G
S
G
T
A
S
L
R
S
N
P
Site 47
S422
S
L
G
S
G
T
A
S
L
R
S
N
P
K
R
Site 48
S425
S
G
T
A
S
L
R
S
N
P
K
R
G
F
Y
Site 49
Y432
S
N
P
K
R
G
F
Y
I
R
A
L
F
D
Y
Site 50
Y439
Y
I
R
A
L
F
D
Y
D
K
T
K
D
C
G
Site 51
T442
A
L
F
D
Y
D
K
T
K
D
C
G
F
L
S
Site 52
S449
T
K
D
C
G
F
L
S
Q
A
L
S
F
R
F
Site 53
S453
G
F
L
S
Q
A
L
S
F
R
F
G
D
V
L
Site 54
S478
W
Q
A
R
R
V
H
S
D
S
E
T
D
D
I
Site 55
S480
A
R
R
V
H
S
D
S
E
T
D
D
I
G
F
Site 56
T482
R
V
H
S
D
S
E
T
D
D
I
G
F
I
P
Site 57
S490
D
D
I
G
F
I
P
S
K
R
R
V
E
R
R
Site 58
S500
R
V
E
R
R
E
W
S
R
L
K
A
K
D
W
Site 59
S509
L
K
A
K
D
W
G
S
S
S
G
S
Q
G
R
Site 60
S511
A
K
D
W
G
S
S
S
G
S
Q
G
R
E
D
Site 61
S513
D
W
G
S
S
S
G
S
Q
G
R
E
D
S
V
Site 62
S519
G
S
Q
G
R
E
D
S
V
L
S
Y
E
T
V
Site 63
S522
G
R
E
D
S
V
L
S
Y
E
T
V
T
Q
M
Site 64
Y523
R
E
D
S
V
L
S
Y
E
T
V
T
Q
M
E
Site 65
Y533
V
T
Q
M
E
V
H
Y
A
R
P
I
I
I
L
Site 66
S553
R
A
N
D
D
L
L
S
E
F
P
D
K
F
G
Site 67
S561
E
F
P
D
K
F
G
S
C
V
P
H
T
T
R
Site 68
T566
F
G
S
C
V
P
H
T
T
R
P
K
R
E
Y
Site 69
Y573
T
T
R
P
K
R
E
Y
E
I
D
G
R
D
Y
Site 70
Y580
Y
E
I
D
G
R
D
Y
H
F
V
S
S
R
E
Site 71
S584
G
R
D
Y
H
F
V
S
S
R
E
K
M
E
K
Site 72
Y604
K
F
I
E
A
G
Q
Y
N
S
H
L
Y
G
T
Site 73
S606
I
E
A
G
Q
Y
N
S
H
L
Y
G
T
S
V
Site 74
Y609
G
Q
Y
N
S
H
L
Y
G
T
S
V
Q
S
V
Site 75
S612
N
S
H
L
Y
G
T
S
V
Q
S
V
R
E
V
Site 76
S615
L
Y
G
T
S
V
Q
S
V
R
E
V
A
E
Q
Site 77
S654
A
I
F
I
R
P
R
S
L
E
N
V
L
E
I
Site 78
T666
L
E
I
N
K
R
I
T
E
E
Q
A
R
K
A
Site 79
T678
R
K
A
F
D
R
A
T
K
L
E
Q
E
F
T
Site 80
S696
S
A
I
V
E
G
D
S
F
E
E
I
Y
H
K
Site 81
Y701
G
D
S
F
E
E
I
Y
H
K
V
K
R
V
I
Site 82
S712
K
R
V
I
E
D
L
S
G
P
Y
I
W
V
P
Site 83
Y715
I
E
D
L
S
G
P
Y
I
W
V
P
A
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation