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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
polycystin 1
Full Name:
Polycystin-1
Alias:
autosomal dominant polycystic kidney disease protein 1; PBP; Pc-1; PKD1; polycystic kidney disease 1 (autosomal dominant); polycystin-1; transient receptor potential cation channel, subfamily P, member 1; TRPP1
Type:
Adhesion protein
Mass (Da):
462529
Number AA:
4303
UniProt ID:
P98161
International Prot ID:
IPI00409566
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005529
PhosphoSite+
KinaseNET
Biological Process:
GO:0007161
GO:0007156
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S52
A
A
C
R
V
N
C
S
G
R
G
L
R
T
L
Site 2
T70
L
R
I
P
A
D
A
T
A
L
D
V
S
H
N
Site 3
S123
N
L
S
E
I
N
L
S
G
N
P
F
E
C
D
Site 4
Y180
D
S
G
C
G
E
E
Y
V
A
C
L
P
D
N
Site 5
T258
P
P
P
P
P
A
P
T
C
R
G
P
T
L
L
Site 6
T303
A
P
L
P
V
T
A
T
R
W
D
F
G
D
G
Site 7
S311
R
W
D
F
G
D
G
S
A
E
V
D
A
A
G
Site 8
S322
D
A
A
G
P
A
A
S
H
R
Y
V
L
P
G
Site 9
Y325
G
P
A
A
S
H
R
Y
V
L
P
G
R
Y
H
Site 10
S366
L
E
L
V
C
P
S
S
V
Q
S
D
E
S
L
Site 11
S369
V
C
P
S
S
V
Q
S
D
E
S
L
D
L
S
Site 12
S372
S
S
V
Q
S
D
E
S
L
D
L
S
I
Q
N
Site 13
S376
S
D
E
S
L
D
L
S
I
Q
N
R
G
G
S
Site 14
S383
S
I
Q
N
R
G
G
S
G
L
E
A
A
Y
S
Site 15
T410
H
P
L
C
P
S
D
T
E
I
F
P
G
N
G
Site 16
S488
A
P
Q
G
E
A
F
S
L
E
S
C
Q
N
W
Site 17
S491
G
E
A
F
S
L
E
S
C
Q
N
W
L
P
G
Site 18
T504
P
G
E
P
H
P
A
T
A
E
H
C
V
R
L
Site 19
S527
D
L
C
S
A
P
H
S
Y
V
C
E
L
Q
P
Site 20
Y528
L
C
S
A
P
H
S
Y
V
C
E
L
Q
P
G
Site 21
T558
G
D
L
Q
G
P
L
T
P
L
A
Q
Q
D
G
Site 22
S567
L
A
Q
Q
D
G
L
S
A
P
H
E
P
V
E
Site 23
T590
L
S
R
E
A
F
L
T
T
A
E
F
G
T
Q
Site 24
S614
L
Q
V
Y
R
L
L
S
T
A
G
T
P
E
N
Site 25
T618
R
L
L
S
T
A
G
T
P
E
N
G
S
E
P
Site 26
S623
A
G
T
P
E
N
G
S
E
P
E
S
R
S
P
Site 27
S627
E
N
G
S
E
P
E
S
R
S
P
D
N
R
T
Site 28
S629
G
S
E
P
E
S
R
S
P
D
N
R
T
Q
L
Site 29
T634
S
R
S
P
D
N
R
T
Q
L
A
P
A
C
M
Site 30
S699
A
G
P
P
A
Q
Y
S
V
T
L
H
G
Q
D
Site 31
S730
P
G
A
L
L
H
C
S
P
A
P
G
H
P
G
Site 32
Y742
H
P
G
P
Q
A
P
Y
L
S
A
N
A
S
S
Site 33
S744
G
P
Q
A
P
Y
L
S
A
N
A
S
S
W
L
Site 34
S748
P
Y
L
S
A
N
A
S
S
W
L
P
H
L
P
Site 35
Y796
G
L
R
M
P
G
R
Y
E
V
R
A
E
V
G
Site 36
S807
A
E
V
G
N
G
V
S
R
H
N
L
S
C
S
Site 37
S812
G
V
S
R
H
N
L
S
C
S
F
D
V
V
S
Site 38
S814
S
R
H
N
L
S
C
S
F
D
V
V
S
P
V
Site 39
Y828
V
A
G
L
R
V
I
Y
P
A
P
R
D
G
R
Site 40
Y837
A
P
R
D
G
R
L
Y
V
P
T
N
G
S
A
Site 41
T858
S
G
A
N
A
T
A
T
A
R
W
P
G
G
S
Site 42
S865
T
A
R
W
P
G
G
S
V
S
A
R
F
E
N
Site 43
S867
R
W
P
G
G
S
V
S
A
R
F
E
N
V
C
Site 44
S918
V
V
V
E
N
S
A
S
R
A
N
L
S
L
R
Site 45
S923
S
A
S
R
A
N
L
S
L
R
V
T
A
E
E
Site 46
T938
P
I
C
G
L
R
A
T
P
S
P
E
A
R
V
Site 47
S940
C
G
L
R
A
T
P
S
P
E
A
R
V
L
Q
Site 48
T976
I
N
D
K
Q
S
L
T
F
Q
N
V
V
F
N
Site 49
S999
F
K
L
S
L
T
A
S
N
H
V
S
N
V
T
Site 50
T1006
S
N
H
V
S
N
V
T
V
N
Y
N
V
T
V
Site 51
Y1071
L
H
Q
F
Q
P
P
Y
N
E
S
F
P
V
P
Site 52
S1074
F
Q
P
P
Y
N
E
S
F
P
V
P
D
P
S
Site 53
Y1095
E
H
N
V
M
H
T
Y
A
A
P
G
E
Y
L
Site 54
S1108
Y
L
L
T
V
L
A
S
N
A
F
E
N
L
T
Site 55
T1115
S
N
A
F
E
N
L
T
Q
Q
V
P
V
S
V
Site 56
Y1147
A
G
R
P
V
T
F
Y
P
H
P
L
P
S
P
Site 57
S1153
F
Y
P
H
P
L
P
S
P
G
G
V
L
Y
T
Site 58
Y1159
P
S
P
G
G
V
L
Y
T
W
D
F
G
D
G
Site 59
T1160
S
P
G
G
V
L
Y
T
W
D
F
G
D
G
S
Site 60
S1167
T
W
D
F
G
D
G
S
P
V
L
T
Q
S
Q
Site 61
T1171
G
D
G
S
P
V
L
T
Q
S
Q
P
A
A
N
Site 62
S1173
G
S
P
V
L
T
Q
S
Q
P
A
A
N
H
T
Site 63
T1180
S
Q
P
A
A
N
H
T
Y
A
S
R
G
T
Y
Site 64
Y1181
Q
P
A
A
N
H
T
Y
A
S
R
G
T
Y
H
Site 65
T1186
H
T
Y
A
S
R
G
T
Y
H
V
R
L
E
V
Site 66
Y1187
T
Y
A
S
R
G
T
Y
H
V
R
L
E
V
N
Site 67
T1251
T
F
D
M
G
D
G
T
V
L
S
G
P
E
A
Site 68
S1254
M
G
D
G
T
V
L
S
G
P
E
A
T
V
E
Site 69
Y1264
E
A
T
V
E
H
V
Y
L
R
A
Q
N
C
T
Site 70
T1314
T
Q
P
D
A
R
L
T
A
Y
V
T
G
N
P
Site 71
Y1316
P
D
A
R
L
T
A
Y
V
T
G
N
P
A
H
Site 72
T1318
A
R
L
T
A
Y
V
T
G
N
P
A
H
Y
L
Site 73
Y1324
V
T
G
N
P
A
H
Y
L
F
D
W
T
F
G
Site 74
S1334
D
W
T
F
G
D
G
S
S
N
T
T
V
R
G
Site 75
T1337
F
G
D
G
S
S
N
T
T
V
R
G
C
P
T
Site 76
T1338
G
D
G
S
S
N
T
T
V
R
G
C
P
T
V
Site 77
T1344
T
T
V
R
G
C
P
T
V
T
H
N
F
T
R
Site 78
Y1370
S
R
V
N
R
A
H
Y
F
T
S
I
C
V
E
Site 79
T1384
E
P
E
V
G
N
V
T
L
Q
P
E
R
Q
F
Site 80
T1418
R
Y
T
W
D
F
G
T
E
E
A
A
P
T
R
Site 81
T1424
G
T
E
E
A
A
P
T
R
A
R
G
P
E
V
Site 82
T1432
R
A
R
G
P
E
V
T
F
I
Y
R
D
P
G
Site 83
Y1435
G
P
E
V
T
F
I
Y
R
D
P
G
S
Y
L
Site 84
T1444
D
P
G
S
Y
L
V
T
V
T
A
S
N
N
I
Site 85
S1452
V
T
A
S
N
N
I
S
A
A
N
D
S
A
L
Site 86
S1476
T
S
I
K
V
N
G
S
L
G
L
E
L
Q
Q
Site 87
Y1485
G
L
E
L
Q
Q
P
Y
L
F
S
A
V
G
R
Site 88
S1488
L
Q
Q
P
Y
L
F
S
A
V
G
R
G
R
P
Site 89
S1497
V
G
R
G
R
P
A
S
Y
L
W
D
L
G
D
Site 90
Y1498
G
R
G
R
P
A
S
Y
L
W
D
L
G
D
G
Site 91
Y1517
G
P
E
V
T
H
A
Y
N
S
T
G
D
F
T
Site 92
S1534
V
A
G
W
N
E
V
S
R
S
E
A
W
L
N
Site 93
S1536
G
W
N
E
V
S
R
S
E
A
W
L
N
V
T
Site 94
T1543
S
E
A
W
L
N
V
T
V
K
R
R
V
R
G
Site 95
S1569
L
N
G
S
V
S
F
S
T
S
L
E
A
G
S
Site 96
S1571
G
S
V
S
F
S
T
S
L
E
A
G
S
D
V
Site 97
S1576
S
T
S
L
E
A
G
S
D
V
R
Y
S
W
V
Site 98
Y1580
E
A
G
S
D
V
R
Y
S
W
V
L
C
D
R
Site 99
Y1599
P
G
G
P
T
I
S
Y
T
F
R
S
V
G
T
Site 100
T1600
G
G
P
T
I
S
Y
T
F
R
S
V
G
T
F
Site 101
S1619
T
A
E
N
E
V
G
S
A
Q
D
S
I
F
V
Site 102
Y1643
Q
V
V
G
G
G
R
Y
F
P
T
N
H
T
V
Site 103
T1646
G
G
G
R
Y
F
P
T
N
H
T
V
Q
L
Q
Site 104
T1660
Q
A
V
V
R
D
G
T
N
V
S
Y
S
W
T
Site 105
S1679
R
G
P
A
L
A
G
S
G
K
G
F
S
L
T
Site 106
S1684
A
G
S
G
K
G
F
S
L
T
V
L
E
A
G
Site 107
T1692
L
T
V
L
E
A
G
T
Y
H
V
Q
L
R
A
Site 108
Y1750
A
G
G
S
G
V
V
Y
T
W
S
L
E
E
G
Site 109
S1753
S
G
V
V
Y
T
W
S
L
E
E
G
L
S
W
Site 110
S1759
W
S
L
E
E
G
L
S
W
E
T
S
E
P
F
Site 111
T1762
E
E
G
L
S
W
E
T
S
E
P
F
T
T
H
Site 112
S1763
E
G
L
S
W
E
T
S
E
P
F
T
T
H
S
Site 113
T1767
W
E
T
S
E
P
F
T
T
H
S
F
P
T
P
Site 114
T1768
E
T
S
E
P
F
T
T
H
S
F
P
T
P
G
Site 115
S1770
S
E
P
F
T
T
H
S
F
P
T
P
G
L
H
Site 116
S1806
Q
V
P
V
S
G
L
S
I
R
A
S
E
P
G
Site 117
S1810
S
G
L
S
I
R
A
S
E
P
G
G
S
F
V
Site 118
S1815
R
A
S
E
P
G
G
S
F
V
A
A
G
S
S
Site 119
S1845
C
W
A
V
P
G
G
S
S
K
R
G
P
H
V
Site 120
S1846
W
A
V
P
G
G
S
S
K
R
G
P
H
V
T
Site 121
T1853
S
K
R
G
P
H
V
T
M
V
F
P
D
A
G
Site 122
T1861
M
V
F
P
D
A
G
T
F
S
I
R
L
N
A
Site 123
S1863
F
P
D
A
G
T
F
S
I
R
L
N
A
S
N
Site 124
S1873
L
N
A
S
N
A
V
S
W
V
S
A
T
Y
N
Site 125
S1937
V
L
P
G
P
R
F
S
H
S
F
P
R
V
G
Site 126
S1939
P
G
P
R
F
S
H
S
F
P
R
V
G
D
H
Site 127
S1949
R
V
G
D
H
V
V
S
V
R
G
K
N
H
V
Site 128
S1957
V
R
G
K
N
H
V
S
W
A
Q
A
Q
V
R
Site 129
T1988
E
P
G
I
A
T
G
T
E
R
N
F
T
A
R
Site 130
T1993
T
G
T
E
R
N
F
T
A
R
V
Q
R
G
S
Site 131
S2000
T
A
R
V
Q
R
G
S
R
V
A
Y
A
W
Y
Site 132
Y2004
Q
R
G
S
R
V
A
Y
A
W
Y
F
S
L
Q
Site 133
Y2007
S
R
V
A
Y
A
W
Y
F
S
L
Q
K
V
Q
Site 134
S2048
R
A
F
N
A
L
G
S
E
N
R
T
L
V
L
Site 135
T2052
A
L
G
S
E
N
R
T
L
V
L
E
V
Q
D
Site 136
Y2063
E
V
Q
D
A
V
Q
Y
V
A
L
Q
S
G
P
Site 137
S2084
A
Q
F
E
A
A
T
S
P
S
P
R
R
V
A
Site 138
S2086
F
E
A
A
T
S
P
S
P
R
R
V
A
Y
H
Site 139
Y2092
P
S
P
R
R
V
A
Y
H
W
D
F
G
D
G
Site 140
S2100
H
W
D
F
G
D
G
S
P
G
Q
D
T
D
E
Site 141
T2105
D
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S
F
D
Q
V
A
Q
Site 293
S3976
G
R
P
R
R
F
T
S
F
D
Q
V
A
Q
L
Site 294
T4018
Q
W
S
V
F
G
K
T
L
C
R
A
L
P
E
Site 295
Y4118
H
A
L
R
G
E
L
Y
R
P
A
W
E
P
Q
Site 296
Y4127
P
A
W
E
P
Q
D
Y
E
M
V
E
L
F
L
Site 297
S4144
L
R
L
W
M
G
L
S
K
V
K
E
F
R
H
Site 298
S4163
E
G
M
E
P
L
P
S
R
S
S
R
G
S
K
Site 299
S4165
M
E
P
L
P
S
R
S
S
R
G
S
K
V
S
Site 300
S4166
E
P
L
P
S
R
S
S
R
G
S
K
V
S
P
Site 301
S4169
P
S
R
S
S
R
G
S
K
V
S
P
D
V
P
Site 302
S4172
S
S
R
G
S
K
V
S
P
D
V
P
P
P
S
Site 303
S4179
S
P
D
V
P
P
P
S
A
G
S
D
A
S
H
Site 304
S4182
V
P
P
P
S
A
G
S
D
A
S
H
P
S
T
Site 305
S4185
P
S
A
G
S
D
A
S
H
P
S
T
S
S
S
Site 306
S4188
G
S
D
A
S
H
P
S
T
S
S
S
Q
L
D
Site 307
T4189
S
D
A
S
H
P
S
T
S
S
S
Q
L
D
G
Site 308
S4190
D
A
S
H
P
S
T
S
S
S
Q
L
D
G
L
Site 309
S4192
S
H
P
S
T
S
S
S
Q
L
D
G
L
S
V
Site 310
S4198
S
S
Q
L
D
G
L
S
V
S
L
G
R
L
G
Site 311
S4200
Q
L
D
G
L
S
V
S
L
G
R
L
G
T
R
Site 312
T4206
V
S
L
G
R
L
G
T
R
C
E
P
E
P
S
Site 313
Y4237
N
Q
A
T
E
D
V
Y
Q
L
E
Q
Q
L
H
Site 314
S4245
Q
L
E
Q
Q
L
H
S
L
Q
G
R
R
S
S
Site 315
S4251
H
S
L
Q
G
R
R
S
S
R
A
P
A
G
S
Site 316
S4252
S
L
Q
G
R
R
S
S
R
A
P
A
G
S
S
Site 317
S4258
S
S
R
A
P
A
G
S
S
R
G
P
S
P
G
Site 318
S4259
S
R
A
P
A
G
S
S
R
G
P
S
P
G
L
Site 319
S4263
A
G
S
S
R
G
P
S
P
G
L
R
P
A
L
Site 320
S4272
G
L
R
P
A
L
P
S
R
L
A
R
A
S
R
Site 321
S4278
P
S
R
L
A
R
A
S
R
G
V
D
L
A
T
Site 322
T4285
S
R
G
V
D
L
A
T
G
P
S
R
T
P
L
Site 323
S4288
V
D
L
A
T
G
P
S
R
T
P
L
R
A
K
Site 324
T4290
L
A
T
G
P
S
R
T
P
L
R
A
K
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation