PhosphoNET

           
Protein Info 
   
Short Name:  FOXO4
Full Name:  Forkhead box protein O4
Alias:  Afx; Afx1; Afxh; Forkhead box O4; Forkhead domain AFX1; Foxo4; Mllt7; Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Translocated to, 7 (AFX1)
Type:  Transcription protein
Mass (Da):  53684
Number AA:  505
UniProt ID:  P98177
International Prot ID:  IPI00024316
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0005634   Uniprot OncoNet
Molecular Function:  GO:0019899  GO:0043565  GO:0003700 PhosphoSite+ KinaseNET
Biological Process:  GO:0000080  GO:0007050  GO:0030154 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T10PGNENSATEAAAIID
Site 2S26DPDFEPQSRPRSCTW
Site 3S30EPQSRPRSCTWPLPR
Site 4T32QSRPRSCTWPLPRPE
Site 5S45PEIANQPSEPPEVEP
Site 6T60DLGEKVHTEGRSEPI
Site 7S71SEPILLPSRLPEPAG
Site 8T89PGILGAVTGPRKGGS
Site 9S96TGPRKGGSRRNAWGN
Site 10S111QSYAELISQAIESAP
Site 11T123SAPEKRLTLAQIYEW
Site 12Y137WMVRTVPYFKDKGDS
Site 13S144YFKDKGDSNSSAGWK
Site 14S146KDKGDSNSSAGWKNS
Site 15S153SSAGWKNSIRHNLSL
Site 16S159NSIRHNLSLHSKFIK
Site 17S175HNEATGKSSWWMLNP
Site 18S176NEATGKSSWWMLNPE
Site 19S187LNPEGGKSGKAPRRR
Site 20S197APRRRAASMDSSSKL
Site 21S200RRAASMDSSSKLLRG
Site 22S201RAASMDSSSKLLRGR
Site 23S202AASMDSSSKLLRGRS
Site 24S209SKLLRGRSKAPKKKP
Site 25S217KAPKKKPSVLPAPPE
Site 26T227PAPPEGATPTSPVGH
Site 27S230PEGATPTSPVGHFAK
Site 28S239VGHFAKWSGSPCSRN
Site 29S241HFAKWSGSPCSRNRE
Site 30S244KWSGSPCSRNREEAD
Site 31T254REEADMWTTFRPRSS
Site 32T255EEADMWTTFRPRSSS
Site 33S260WTTFRPRSSSNASSV
Site 34S261TTFRPRSSSNASSVS
Site 35S262TFRPRSSSNASSVST
Site 36S265PRSSSNASSVSTRLS
Site 37S266RSSSNASSVSTRLSP
Site 38S268SSNASSVSTRLSPLR
Site 39T269SNASSVSTRLSPLRP
Site 40S272SSVSTRLSPLRPESE
Site 41S278LSPLRPESEVLAEEI
Site 42S288LAEEIPASVSSYAGG
Site 43S290EEIPASVSSYAGGVP
Site 44Y292IPASVSSYAGGVPPT
Site 45T299YAGGVPPTLNEGLEL
Site 46S314LDGLNLTSSHSLLSR
Site 47S315DGLNLTSSHSLLSRS
Site 48S317LNLTSSHSLLSRSGL
Site 49S320TSSHSLLSRSGLSGF
Site 50S322SHSLLSRSGLSGFSL
Site 51S325LLSRSGLSGFSLQHP
Site 52S328RSGLSGFSLQHPGVT
Site 53T340GVTGPLHTYSSSLFS
Site 54Y341VTGPLHTYSSSLFSP
Site 55S342TGPLHTYSSSLFSPA
Site 56S343GPLHTYSSSLFSPAE
Site 57S344PLHTYSSSLFSPAEG
Site 58S347TYSSSLFSPAEGPLS
Site 59S354SPAEGPLSAGEGCFS
Site 60S361SAGEGCFSSSQALEA
Site 61T371QALEALLTSDTPPPP
Site 62S372ALEALLTSDTPPPPA
Site 63T374EALLTSDTPPPPADV
Site 64T410PSSSKLATGVGLCPK
Site 65T451PIPKALGTPVLTPPT
Site 66T455ALGTPVLTPPTEAAS
Site 67T458TPVLTPPTEAASQDR
Site 68S462TPPTEAASQDRMPQD
Site 69Y475QDLDLDMYMENLECD
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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