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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLTC
Full Name:
Clathrin heavy chain 1
Alias:
Clathrin heavy chain; Clathrin, heavy chain; Clathrin, heavy polypeptide (Hc); CLH; CLH1; CLH17; CLH-17; CLTCL2; Hc; KIAA0034
Type:
Vesicle protein
Mass (Da):
191615
Number AA:
1675
UniProt ID:
Q00610
International Prot ID:
IPI00024067
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030132
GO:0030130
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0016044
GO:0006892
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
P
A
N
I
G
F
S
T
L
T
M
E
S
D
K
Site 2
S67
N
P
I
R
R
P
I
S
A
D
S
A
I
M
N
Site 3
S70
R
R
P
I
S
A
D
S
A
I
M
N
P
A
S
Site 4
T103
K
S
K
M
K
A
H
T
M
T
D
D
V
T
F
Site 5
T105
K
M
K
A
H
T
M
T
D
D
V
T
F
W
K
Site 6
S146
V
K
M
F
D
R
H
S
S
L
A
G
C
Q
I
Site 7
S147
K
M
F
D
R
H
S
S
L
A
G
C
Q
I
I
Site 8
Y156
A
G
C
Q
I
I
N
Y
R
T
D
A
K
Q
K
Site 9
T158
C
Q
I
I
N
Y
R
T
D
A
K
Q
K
W
L
Site 10
Y184
V
V
G
A
M
Q
L
Y
S
V
D
R
K
V
S
Site 11
S185
V
G
A
M
Q
L
Y
S
V
D
R
K
V
S
Q
Site 12
S191
Y
S
V
D
R
K
V
S
Q
P
I
E
G
H
A
Site 13
S200
P
I
E
G
H
A
A
S
F
A
Q
F
K
M
E
Site 14
T235
L
H
I
I
E
V
G
T
P
P
T
G
N
Q
P
Site 15
T238
I
E
V
G
T
P
P
T
G
N
Q
P
F
P
K
Site 16
Y285
K
Y
G
Y
I
H
L
Y
D
L
E
T
G
T
C
Site 17
Y294
L
E
T
G
T
C
I
Y
M
N
R
I
S
G
E
Site 18
S299
C
I
Y
M
N
R
I
S
G
E
T
I
F
V
T
Site 19
T302
M
N
R
I
S
G
E
T
I
F
V
T
A
P
H
Site 20
S326
N
R
K
G
Q
V
L
S
V
C
V
E
E
E
N
Site 21
Y337
E
E
E
N
I
I
P
Y
I
T
N
V
L
Q
N
Site 22
T394
A
P
K
G
I
L
R
T
P
D
T
I
R
R
F
Site 23
T397
G
I
L
R
T
P
D
T
I
R
R
F
Q
S
V
Site 24
S403
D
T
I
R
R
F
Q
S
V
P
A
Q
P
G
Q
Site 25
T411
V
P
A
Q
P
G
Q
T
S
P
L
L
Q
Y
F
Site 26
S412
P
A
Q
P
G
Q
T
S
P
L
L
Q
Y
F
G
Site 27
Y430
D
Q
G
Q
L
N
K
Y
E
S
L
E
L
C
R
Site 28
S432
G
Q
L
N
K
Y
E
S
L
E
L
C
R
P
V
Site 29
S460
K
E
D
K
L
E
C
S
E
E
L
G
D
L
V
Site 30
T473
L
V
K
S
V
D
P
T
L
A
L
S
V
Y
L
Site 31
T495
V
I
Q
C
F
A
E
T
G
Q
V
Q
K
I
V
Site 32
Y504
Q
V
Q
K
I
V
L
Y
A
K
K
V
G
Y
T
Site 33
Y510
L
Y
A
K
K
V
G
Y
T
P
D
W
I
F
L
Site 34
S525
L
R
N
V
M
R
I
S
P
D
Q
G
Q
Q
F
Site 35
Y556
I
V
D
V
F
M
E
Y
N
L
I
Q
Q
C
T
Site 36
S576
A
L
K
N
N
R
P
S
E
G
P
L
Q
T
R
Site 37
Y608
G
N
Q
M
F
T
H
Y
D
R
A
H
I
A
Q
Site 38
Y634
L
E
H
F
T
D
L
Y
D
I
K
R
A
V
V
Site 39
T643
I
K
R
A
V
V
H
T
H
L
L
N
P
E
W
Site 40
Y654
N
P
E
W
L
V
N
Y
F
G
S
L
S
V
E
Site 41
S672
E
C
L
R
A
M
L
S
A
N
I
R
Q
N
L
Site 42
Y689
C
V
Q
V
A
S
K
Y
H
E
Q
L
S
T
Q
Site 43
S694
S
K
Y
H
E
Q
L
S
T
Q
S
L
I
E
L
Site 44
T695
K
Y
H
E
Q
L
S
T
Q
S
L
I
E
L
F
Site 45
S722
L
G
S
I
V
N
F
S
Q
D
P
D
V
H
F
Site 46
Y731
D
P
D
V
H
F
K
Y
I
Q
A
A
C
K
T
Site 47
Y754
I
C
R
E
S
N
C
Y
D
P
E
R
V
K
N
Site 48
T769
F
L
K
E
A
K
L
T
D
Q
L
P
L
I
I
Site 49
Y792
H
D
L
V
L
Y
L
Y
R
N
N
L
Q
K
Y
Site 50
Y799
Y
R
N
N
L
Q
K
Y
I
E
I
Y
V
Q
K
Site 51
Y803
L
Q
K
Y
I
E
I
Y
V
Q
K
V
N
P
S
Site 52
T875
E
G
C
E
E
P
A
T
H
N
A
L
A
K
I
Site 53
Y883
H
N
A
L
A
K
I
Y
I
D
S
N
N
N
P
Site 54
S886
L
A
K
I
Y
I
D
S
N
N
N
P
E
R
F
Site 55
Y899
R
F
L
R
E
N
P
Y
Y
D
S
R
V
V
G
Site 56
Y900
F
L
R
E
N
P
Y
Y
D
S
R
V
V
G
K
Site 57
S902
R
E
N
P
Y
Y
D
S
R
V
V
G
K
Y
C
Site 58
Y908
D
S
R
V
V
G
K
Y
C
E
K
R
D
P
H
Site 59
Y921
P
H
L
A
C
V
A
Y
E
R
G
Q
C
D
L
Site 60
S938
I
N
V
C
N
E
N
S
L
F
K
S
L
S
R
Site 61
S942
N
E
N
S
L
F
K
S
L
S
R
Y
L
V
R
Site 62
S944
N
S
L
F
K
S
L
S
R
Y
L
V
R
R
K
Site 63
Y946
L
F
K
S
L
S
R
Y
L
V
R
R
K
D
P
Site 64
S958
K
D
P
E
L
W
G
S
V
L
L
E
S
N
P
Site 65
Y966
V
L
L
E
S
N
P
Y
R
R
P
L
I
D
Q
Site 66
S1016
E
K
I
V
L
D
N
S
V
F
S
E
H
R
N
Site 67
S1019
V
L
D
N
S
V
F
S
E
H
R
N
L
Q
N
Site 68
Y1043
D
R
T
R
V
M
E
Y
I
N
R
L
D
N
Y
Site 69
Y1050
Y
I
N
R
L
D
N
Y
D
A
P
D
I
A
N
Site 70
Y1096
I
G
N
L
D
R
A
Y
E
F
A
E
R
C
N
Site 71
S1127
M
V
K
E
A
I
D
S
Y
I
K
A
D
D
P
Site 72
Y1128
V
K
E
A
I
D
S
Y
I
K
A
D
D
P
S
Site 73
S1135
Y
I
K
A
D
D
P
S
S
Y
M
E
V
V
Q
Site 74
S1136
I
K
A
D
D
P
S
S
Y
M
E
V
V
Q
A
Site 75
Y1137
K
A
D
D
P
S
S
Y
M
E
V
V
Q
A
A
Site 76
Y1156
N
W
E
E
L
V
K
Y
L
Q
M
A
R
K
K
Site 77
S1167
A
R
K
K
A
R
E
S
Y
V
E
T
E
L
I
Site 78
Y1168
R
K
K
A
R
E
S
Y
V
E
T
E
L
I
F
Site 79
Y1206
Q
Q
V
G
D
R
C
Y
D
E
K
M
Y
D
A
Site 80
Y1211
R
C
Y
D
E
K
M
Y
D
A
A
K
L
L
Y
Site 81
Y1218
Y
D
A
A
K
L
L
Y
N
N
V
S
N
F
G
Site 82
S1222
K
L
L
Y
N
N
V
S
N
F
G
R
L
A
S
Site 83
S1229
S
N
F
G
R
L
A
S
T
L
V
H
L
G
E
Site 84
Y1237
T
L
V
H
L
G
E
Y
Q
A
A
V
D
G
A
Site 85
S1249
D
G
A
R
K
A
N
S
T
R
T
W
K
E
V
Site 86
T1250
G
A
R
K
A
N
S
T
R
T
W
K
E
V
C
Site 87
Y1289
E
L
E
E
L
I
N
Y
Y
Q
D
R
G
Y
F
Site 88
Y1290
L
E
E
L
I
N
Y
Y
Q
D
R
G
Y
F
E
Site 89
Y1295
N
Y
Y
Q
D
R
G
Y
F
E
E
L
I
T
M
Site 90
Y1324
F
T
E
L
A
I
L
Y
S
K
F
K
P
Q
K
Site 91
S1325
T
E
L
A
I
L
Y
S
K
F
K
P
Q
K
M
Site 92
S1341
E
H
L
E
L
F
W
S
R
V
N
I
P
K
V
Site 93
Y1365
W
A
E
L
V
F
L
Y
D
K
Y
E
E
Y
D
Site 94
Y1368
L
V
F
L
Y
D
K
Y
E
E
Y
D
N
A
I
Site 95
Y1371
L
Y
D
K
Y
E
E
Y
D
N
A
I
I
T
M
Site 96
T1396
G
Q
F
K
D
I
I
T
K
V
A
N
V
E
L
Site 97
Y1404
K
V
A
N
V
E
L
Y
Y
R
A
I
Q
F
Y
Site 98
S1427
N
D
L
L
M
V
L
S
P
R
L
D
H
T
R
Site 99
T1433
L
S
P
R
L
D
H
T
R
A
V
N
Y
F
S
Site 100
Y1438
D
H
T
R
A
V
N
Y
F
S
K
V
K
Q
L
Site 101
S1440
T
R
A
V
N
Y
F
S
K
V
K
Q
L
P
L
Site 102
Y1451
Q
L
P
L
V
K
P
Y
L
R
S
V
Q
N
H
Site 103
S1462
V
Q
N
H
N
N
K
S
V
N
E
S
L
N
N
Site 104
S1466
N
N
K
S
V
N
E
S
L
N
N
L
F
I
T
Site 105
Y1477
L
F
I
T
E
E
D
Y
Q
A
L
R
T
S
I
Site 106
T1482
E
D
Y
Q
A
L
R
T
S
I
D
A
Y
D
N
Site 107
S1483
D
Y
Q
A
L
R
T
S
I
D
A
Y
D
N
F
Site 108
Y1487
L
R
T
S
I
D
A
Y
D
N
F
D
N
I
S
Site 109
S1494
Y
D
N
F
D
N
I
S
L
A
Q
R
L
E
K
Site 110
Y1513
E
F
R
R
I
A
A
Y
L
F
K
G
N
N
R
Site 111
S1532
V
E
L
C
K
K
D
S
L
Y
K
D
A
M
Q
Site 112
Y1534
L
C
K
K
D
S
L
Y
K
D
A
M
Q
Y
A
Site 113
S1544
A
M
Q
Y
A
S
E
S
K
D
T
E
L
A
E
Site 114
T1547
Y
A
S
E
S
K
D
T
E
L
A
E
E
L
L
Site 115
T1608
Q
V
M
K
E
Y
L
T
K
V
D
K
L
D
A
Site 116
S1616
K
V
D
K
L
D
A
S
E
S
L
R
K
E
E
Site 117
S1618
D
K
L
D
A
S
E
S
L
R
K
E
E
E
Q
Site 118
T1627
R
K
E
E
E
Q
A
T
E
T
Q
P
I
V
Y
Site 119
Y1634
T
E
T
Q
P
I
V
Y
G
Q
P
Q
L
M
L
Site 120
Y1657
P
P
Q
A
P
F
G
Y
G
Y
T
A
P
P
Y
Site 121
Y1659
Q
A
P
F
G
Y
G
Y
T
A
P
P
Y
G
Q
Site 122
T1660
A
P
F
G
Y
G
Y
T
A
P
P
Y
G
Q
P
Site 123
Y1664
Y
G
Y
T
A
P
P
Y
G
Q
P
Q
P
G
F
Site 124
Y1673
Q
P
Q
P
G
F
G
Y
S
M
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation