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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFKB2
Full Name:
Nuclear factor NF-kappa-B p100 subunit
Alias:
DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10; Lyt10; LYT-10; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); Oncogene Lyt-10; P52
Type:
Transcription protein
Mass (Da):
96749
Number AA:
900
UniProt ID:
Q00653
International Prot ID:
IPI00024116
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0033257
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003713
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0007165
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
G
L
D
G
I
I
E
Y
D
D
F
K
L
N
S
Site 2
S22
Y
D
D
F
K
L
N
S
S
I
V
E
P
K
E
Site 3
S23
D
D
F
K
L
N
S
S
I
V
E
P
K
E
P
Site 4
Y39
P
E
T
A
D
G
P
Y
L
V
I
V
E
Q
P
Site 5
Y55
Q
R
G
F
R
F
R
Y
G
C
E
G
P
S
H
Site 6
S61
R
Y
G
C
E
G
P
S
H
G
G
L
P
G
A
Site 7
S70
G
G
L
P
G
A
S
S
E
K
G
R
K
T
Y
Site 8
T76
S
S
E
K
G
R
K
T
Y
P
T
V
K
I
C
Site 9
Y77
S
E
K
G
R
K
T
Y
P
T
V
K
I
C
N
Site 10
T79
K
G
R
K
T
Y
P
T
V
K
I
C
N
Y
E
Site 11
Y85
P
T
V
K
I
C
N
Y
E
G
P
A
K
I
E
Site 12
T97
K
I
E
V
D
L
V
T
H
S
D
P
P
R
A
Site 13
S99
E
V
D
L
V
T
H
S
D
P
P
R
A
H
A
Site 14
S108
P
P
R
A
H
A
H
S
L
V
G
K
Q
C
S
Site 15
S115
S
L
V
G
K
Q
C
S
E
L
G
I
C
A
V
Site 16
S123
E
L
G
I
C
A
V
S
V
G
P
K
D
M
T
Site 17
T130
S
V
G
P
K
D
M
T
A
Q
F
N
N
L
G
Site 18
S161
L
Q
R
Q
R
L
R
S
R
P
Q
G
L
T
E
Site 19
T167
R
S
R
P
Q
G
L
T
E
A
E
Q
R
E
L
Site 20
S204
F
L
R
A
S
D
G
S
F
S
L
P
L
K
P
Site 21
S214
L
P
L
K
P
V
I
S
Q
P
I
H
D
S
K
Site 22
S220
I
S
Q
P
I
H
D
S
K
S
P
G
A
S
N
Site 23
S222
Q
P
I
H
D
S
K
S
P
G
A
S
N
L
K
Site 24
S226
D
S
K
S
P
G
A
S
N
L
K
I
S
R
M
Site 25
T236
K
I
S
R
M
D
K
T
A
G
S
V
R
G
G
Site 26
S239
R
M
D
K
T
A
G
S
V
R
G
G
D
E
V
Site 27
Y247
V
R
G
G
D
E
V
Y
L
L
C
D
K
V
Q
Site 28
Y263
D
D
I
E
V
R
F
Y
E
D
D
E
N
G
W
Site 29
S277
W
Q
A
F
G
D
F
S
P
T
D
V
H
K
Q
Site 30
Y285
P
T
D
V
H
K
Q
Y
A
I
V
F
R
T
P
Site 31
T291
Q
Y
A
I
V
F
R
T
P
P
Y
H
K
M
K
Site 32
Y294
I
V
F
R
T
P
P
Y
H
K
M
K
I
E
R
Site 33
T304
M
K
I
E
R
P
V
T
V
F
L
Q
L
K
R
Site 34
S318
R
K
R
G
G
D
V
S
D
S
K
Q
F
T
Y
Site 35
S320
R
G
G
D
V
S
D
S
K
Q
F
T
Y
Y
P
Site 36
T324
V
S
D
S
K
Q
F
T
Y
Y
P
L
V
E
D
Site 37
Y325
S
D
S
K
Q
F
T
Y
Y
P
L
V
E
D
K
Site 38
Y326
D
S
K
Q
F
T
Y
Y
P
L
V
E
D
K
E
Site 39
T345
K
R
R
K
A
L
P
T
F
S
Q
P
F
G
G
Site 40
S347
R
K
A
L
P
T
F
S
Q
P
F
G
G
G
S
Site 41
S354
S
Q
P
F
G
G
G
S
H
M
G
G
G
S
G
Site 42
S360
G
S
H
M
G
G
G
S
G
G
A
A
G
G
Y
Site 43
Y367
S
G
G
A
A
G
G
Y
G
G
A
G
G
G
G
Site 44
S382
S
L
G
F
F
P
S
S
L
A
Y
S
P
Y
Q
Site 45
Y385
F
F
P
S
S
L
A
Y
S
P
Y
Q
S
G
A
Site 46
S386
F
P
S
S
L
A
Y
S
P
Y
Q
S
G
A
G
Site 47
Y388
S
S
L
A
Y
S
P
Y
Q
S
G
A
G
P
M
Site 48
S390
L
A
Y
S
P
Y
Q
S
G
A
G
P
M
G
C
Site 49
Y398
G
A
G
P
M
G
C
Y
P
G
G
G
G
G
A
Site 50
T410
G
G
A
Q
M
A
A
T
V
P
S
R
D
S
G
Site 51
S416
A
T
V
P
S
R
D
S
G
E
E
A
A
E
P
Site 52
S424
G
E
E
A
A
E
P
S
A
P
S
R
T
P
Q
Site 53
T429
E
P
S
A
P
S
R
T
P
Q
C
E
P
Q
A
Site 54
Y446
M
L
Q
R
A
R
E
Y
N
A
R
L
F
G
L
Site 55
Y464
S
A
R
A
L
L
D
Y
G
V
T
A
D
A
R
Site 56
T482
A
G
Q
R
H
L
L
T
A
Q
D
E
N
G
D
Site 57
T490
A
Q
D
E
N
G
D
T
P
L
H
L
A
I
I
Site 58
S562
L
L
D
R
H
G
D
S
A
M
H
L
A
L
R
Site 59
T629
S
G
A
E
V
E
A
T
E
R
Q
G
G
R
T
Site 60
T665
R
A
N
V
N
A
R
T
F
A
G
N
T
P
L
Site 61
S707
E
P
L
C
P
L
P
S
P
P
T
S
D
S
D
Site 62
T710
C
P
L
P
S
P
P
T
S
D
S
D
S
D
S
Site 63
S711
P
L
P
S
P
P
T
S
D
S
D
S
D
S
E
Site 64
S713
P
S
P
P
T
S
D
S
D
S
D
S
E
G
P
Site 65
S715
P
P
T
S
D
S
D
S
D
S
E
G
P
E
K
Site 66
S717
T
S
D
S
D
S
D
S
E
G
P
E
K
D
T
Site 67
T724
S
E
G
P
E
K
D
T
R
S
S
F
R
G
H
Site 68
S726
G
P
E
K
D
T
R
S
S
F
R
G
H
T
P
Site 69
S727
P
E
K
D
T
R
S
S
F
R
G
H
T
P
L
Site 70
T732
R
S
S
F
R
G
H
T
P
L
D
L
T
C
S
Site 71
T737
G
H
T
P
L
D
L
T
C
S
T
K
V
K
T
Site 72
T759
N
T
M
E
P
P
L
T
P
P
S
P
A
G
P
Site 73
S762
E
P
P
L
T
P
P
S
P
A
G
P
G
L
S
Site 74
S769
S
P
A
G
P
G
L
S
L
G
D
T
A
L
Q
Site 75
T773
P
G
L
S
L
G
D
T
A
L
Q
N
L
E
Q
Site 76
S790
D
G
P
E
A
Q
G
S
W
A
E
L
A
E
R
Site 77
S802
A
E
R
L
G
L
R
S
L
V
D
T
Y
R
Q
Site 78
T806
G
L
R
S
L
V
D
T
Y
R
Q
T
T
S
P
Site 79
Y807
L
R
S
L
V
D
T
Y
R
Q
T
T
S
P
S
Site 80
T810
L
V
D
T
Y
R
Q
T
T
S
P
S
G
S
L
Site 81
T811
V
D
T
Y
R
Q
T
T
S
P
S
G
S
L
L
Site 82
S812
D
T
Y
R
Q
T
T
S
P
S
G
S
L
L
R
Site 83
S814
Y
R
Q
T
T
S
P
S
G
S
L
L
R
S
Y
Site 84
S816
Q
T
T
S
P
S
G
S
L
L
R
S
Y
E
L
Site 85
S820
P
S
G
S
L
L
R
S
Y
E
L
A
G
G
D
Site 86
Y821
S
G
S
L
L
R
S
Y
E
L
A
G
G
D
L
Site 87
T852
R
L
L
R
G
P
E
T
R
D
K
L
P
S
T
Site 88
S858
E
T
R
D
K
L
P
S
T
A
E
V
K
E
D
Site 89
T859
T
R
D
K
L
P
S
T
A
E
V
K
E
D
S
Site 90
S866
T
A
E
V
K
E
D
S
A
Y
G
S
Q
S
V
Site 91
Y868
E
V
K
E
D
S
A
Y
G
S
Q
S
V
E
Q
Site 92
S870
K
E
D
S
A
Y
G
S
Q
S
V
E
Q
E
A
Site 93
S872
D
S
A
Y
G
S
Q
S
V
E
Q
E
A
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation