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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HNRNPU
Full Name:
Heterogeneous nuclear ribonucleoprotein U
Alias:
Heterogeneous nuclear ribonucleoprotein U; Heterogenous nuclear ribonucleoprotein U; HnRNP U; HNRPU; SAFA; SAF-A; Scaffold attachment factor A; U21.1
Type:
RNA binding protein; DNA binding protein; Nuclear receptor co-regulator
Mass (Da):
90584
Number AA:
825
UniProt ID:
Q00839
International Prot ID:
IPI00644079
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0009986
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
S
P
V
N
V
K
Site 2
S3
_
_
_
_
_
M
S
S
S
P
V
N
V
K
K
Site 3
S4
_
_
_
_
M
S
S
S
P
V
N
V
K
K
L
Site 4
S14
N
V
K
K
L
K
V
S
E
L
K
E
E
L
K
Site 5
S26
E
L
K
K
R
R
L
S
D
K
G
L
K
A
E
Site 6
S59
A
M
E
P
G
N
G
S
L
D
L
G
G
D
S
Site 7
S66
S
L
D
L
G
G
D
S
A
G
R
S
G
A
G
Site 8
S70
G
G
D
S
A
G
R
S
G
A
G
L
E
Q
E
Site 9
S97
E
E
E
E
E
G
I
S
A
L
D
G
D
Q
M
Site 10
S118
G
A
A
G
A
A
D
S
G
P
M
E
E
E
E
Site 11
S128
M
E
E
E
E
A
A
S
E
D
E
N
G
D
D
Site 12
T168
Q
Q
P
Q
P
P
A
T
Q
Q
Q
Q
P
Q
Q
Site 13
S187
A
K
E
A
A
G
K
S
S
G
P
T
S
L
F
Site 14
S188
K
E
A
A
G
K
S
S
G
P
T
S
L
F
A
Site 15
T191
A
G
K
S
S
G
P
T
S
L
F
A
V
T
V
Site 16
S192
G
K
S
S
G
P
T
S
L
F
A
V
T
V
A
Site 17
T235
P
A
A
G
D
G
K
T
E
Q
K
G
G
D
K
Site 18
Y257
R
E
D
H
G
R
G
Y
F
E
Y
I
E
E
N
Site 19
Y260
H
G
R
G
Y
F
E
Y
I
E
E
N
K
Y
S
Site 20
Y266
E
Y
I
E
E
N
K
Y
S
R
A
K
S
P
Q
Site 21
S267
Y
I
E
E
N
K
Y
S
R
A
K
S
P
Q
P
Site 22
S271
N
K
Y
S
R
A
K
S
P
Q
P
P
V
E
E
Site 23
T286
E
D
E
H
F
D
D
T
V
V
C
L
D
T
Y
Site 24
T292
D
T
V
V
C
L
D
T
Y
N
C
D
L
H
F
Site 25
Y293
T
V
V
C
L
D
T
Y
N
C
D
L
H
F
K
Site 26
S302
C
D
L
H
F
K
I
S
R
D
R
L
S
A
S
Site 27
S307
K
I
S
R
D
R
L
S
A
S
S
L
T
M
E
Site 28
S309
S
R
D
R
L
S
A
S
S
L
T
M
E
S
F
Site 29
S310
R
D
R
L
S
A
S
S
L
T
M
E
S
F
A
Site 30
S315
A
S
S
L
T
M
E
S
F
A
F
L
W
A
G
Site 31
S326
L
W
A
G
G
R
A
S
Y
G
V
S
K
G
K
Site 32
Y327
W
A
G
G
R
A
S
Y
G
V
S
K
G
K
V
Site 33
S330
G
R
A
S
Y
G
V
S
K
G
K
V
C
F
E
Site 34
T341
V
C
F
E
M
K
V
T
E
K
I
P
V
R
H
Site 35
Y350
K
I
P
V
R
H
L
Y
T
K
D
I
D
I
H
Site 36
S378
L
L
G
E
E
E
F
S
Y
G
Y
S
L
K
G
Site 37
Y379
L
G
E
E
E
F
S
Y
G
Y
S
L
K
G
I
Site 38
S382
E
E
F
S
Y
G
Y
S
L
K
G
I
K
T
C
Site 39
T388
Y
S
L
K
G
I
K
T
C
N
C
E
T
E
D
Site 40
Y396
C
N
C
E
T
E
D
Y
G
E
K
F
D
E
N
Site 41
S414
T
C
F
A
N
F
E
S
D
E
V
E
L
S
Y
Site 42
S420
E
S
D
E
V
E
L
S
Y
A
K
N
G
Q
D
Site 43
Y421
S
D
E
V
E
L
S
Y
A
K
N
G
Q
D
L
Site 44
S435
L
G
V
A
F
K
I
S
K
E
V
L
A
G
R
Site 45
Y466
F
G
Q
K
E
K
P
Y
F
P
I
P
E
E
Y
Site 46
Y473
Y
F
P
I
P
E
E
Y
T
F
I
Q
N
V
P
Site 47
T474
F
P
I
P
E
E
Y
T
F
I
Q
N
V
P
L
Site 48
T511
G
L
P
G
A
G
K
T
T
W
V
T
K
H
A
Site 49
Y525
A
A
E
N
P
G
K
Y
N
I
L
G
T
N
T
Site 50
T549
F
K
K
Q
M
A
D
T
G
K
L
N
T
L
L
Site 51
T582
R
N
F
I
L
D
Q
T
N
V
S
A
A
A
Q
Site 52
Y613
V
C
P
K
D
E
D
Y
K
Q
R
T
Q
K
K
Site 53
T653
A
E
C
F
D
E
I
T
Y
V
E
L
Q
K
E
Site 54
Y654
E
C
F
D
E
I
T
Y
V
E
L
Q
K
E
E
Site 55
Y669
A
Q
K
L
L
E
Q
Y
K
E
E
S
K
K
A
Site 56
S673
L
E
Q
Y
K
E
E
S
K
K
A
L
P
P
E
Site 57
T685
P
P
E
K
K
Q
N
T
G
S
K
K
S
N
K
Site 58
S690
Q
N
T
G
S
K
K
S
N
K
N
K
S
G
K
Site 59
S695
K
K
S
N
K
N
K
S
G
K
N
Q
F
N
R
Site 60
Y730
A
P
G
N
R
G
G
Y
N
R
R
G
N
M
P
Site 61
S746
R
G
G
G
G
G
G
S
G
G
I
G
Y
P
Y
Site 62
Y751
G
G
S
G
G
I
G
Y
P
Y
P
R
A
P
V
Site 63
Y753
S
G
G
I
G
Y
P
Y
P
R
A
P
V
F
P
Site 64
S764
P
V
F
P
G
R
G
S
Y
S
N
R
G
N
Y
Site 65
Y765
V
F
P
G
R
G
S
Y
S
N
R
G
N
Y
N
Site 66
S766
F
P
G
R
G
S
Y
S
N
R
G
N
Y
N
R
Site 67
Y771
S
Y
S
N
R
G
N
Y
N
R
G
G
M
P
N
Site 68
Y782
G
M
P
N
R
G
N
Y
N
Q
N
F
R
G
R
Site 69
Y795
G
R
G
N
N
R
G
Y
K
N
Q
S
Q
G
Y
Site 70
S799
N
R
G
Y
K
N
Q
S
Q
G
Y
N
Q
W
Q
Site 71
Y802
Y
K
N
Q
S
Q
G
Y
N
Q
W
Q
Q
G
Q
Site 72
S817
F
W
G
Q
K
P
W
S
Q
H
Y
H
Q
G
Y
Site 73
Y820
Q
K
P
W
S
Q
H
Y
H
Q
G
Y
Y
_
_
Site 74
Y824
S
Q
H
Y
H
Q
G
Y
Y
_
_
_
_
_
_
Site 75
Y825
Q
H
Y
H
Q
G
Y
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation