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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
E2F1
Full Name:
Transcription factor E2F1
Alias:
E2F transcription factor 1; E2F-1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBBP3; RBBP-3; RBP3; Retinoblastoma binding protein 3; Retinoblastoma-associated protein 1
Type:
Transcription protein
Mass (Da):
46920
Number AA:
437
UniProt ID:
Q01094
International Prot ID:
IPI00005630
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0003714
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0000080
GO:0006915
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
A
L
R
L
L
D
S
S
Q
I
V
I
I
S
A
Site 2
S43
I
S
A
A
Q
D
A
S
A
P
P
A
P
T
G
Site 3
T68
P
D
L
L
L
F
A
T
P
Q
A
P
R
P
T
Site 4
T75
T
P
Q
A
P
R
P
T
P
S
A
P
R
P
A
Site 5
S77
Q
A
P
R
P
T
P
S
A
P
R
P
A
L
G
Site 6
T96
K
R
R
L
D
L
E
T
D
H
Q
Y
L
A
E
Site 7
Y100
D
L
E
T
D
H
Q
Y
L
A
E
S
S
G
P
Site 8
S104
D
H
Q
Y
L
A
E
S
S
G
P
A
R
G
R
Site 9
S105
H
Q
Y
L
A
E
S
S
G
P
A
R
G
R
G
Site 10
S121
H
P
G
K
G
V
K
S
P
G
E
K
S
R
Y
Site 11
S126
V
K
S
P
G
E
K
S
R
Y
E
T
S
L
N
Site 12
Y128
S
P
G
E
K
S
R
Y
E
T
S
L
N
L
T
Site 13
T130
G
E
K
S
R
Y
E
T
S
L
N
L
T
T
K
Site 14
S131
E
K
S
R
Y
E
T
S
L
N
L
T
T
K
R
Site 15
T135
Y
E
T
S
L
N
L
T
T
K
R
F
L
E
L
Site 16
T136
E
T
S
L
N
L
T
T
K
R
F
L
E
L
L
Site 17
Y168
K
V
Q
K
R
R
I
Y
D
I
T
N
V
L
E
Site 18
T171
K
R
R
I
Y
D
I
T
N
V
L
E
G
I
Q
Site 19
T196
Q
W
L
G
S
H
T
T
V
G
V
G
G
R
L
Site 20
T207
G
G
R
L
E
G
L
T
Q
D
L
R
Q
L
Q
Site 21
S216
D
L
R
Q
L
Q
E
S
E
Q
Q
L
D
H
L
Site 22
S235
T
T
Q
L
R
L
L
S
E
D
T
D
S
Q
R
Site 23
T238
L
R
L
L
S
E
D
T
D
S
Q
R
L
A
Y
Site 24
S240
L
L
S
E
D
T
D
S
Q
R
L
A
Y
V
T
Site 25
Y245
T
D
S
Q
R
L
A
Y
V
T
C
Q
D
L
R
Site 26
T247
S
Q
R
L
A
Y
V
T
C
Q
D
L
R
S
I
Site 27
S278
T
Q
L
Q
A
V
D
S
S
E
N
F
Q
I
S
Site 28
S285
S
S
E
N
F
Q
I
S
L
K
S
K
Q
G
P
Site 29
S307
E
E
T
V
G
G
I
S
P
G
K
T
P
S
Q
Site 30
T311
G
G
I
S
P
G
K
T
P
S
Q
E
V
T
S
Site 31
S313
I
S
P
G
K
T
P
S
Q
E
V
T
S
E
E
Site 32
T317
K
T
P
S
Q
E
V
T
S
E
E
E
N
R
A
Site 33
T325
S
E
E
E
N
R
A
T
D
S
A
T
I
V
S
Site 34
S327
E
E
N
R
A
T
D
S
A
T
I
V
S
P
P
Site 35
T329
N
R
A
T
D
S
A
T
I
V
S
P
P
P
S
Site 36
S332
T
D
S
A
T
I
V
S
P
P
P
S
S
P
P
Site 37
S336
T
I
V
S
P
P
P
S
S
P
P
S
S
L
T
Site 38
S337
I
V
S
P
P
P
S
S
P
P
S
S
L
T
T
Site 39
S340
P
P
P
S
S
P
P
S
S
L
T
T
D
P
S
Site 40
S341
P
P
S
S
P
P
S
S
L
T
T
D
P
S
Q
Site 41
T343
S
S
P
P
S
S
L
T
T
D
P
S
Q
S
L
Site 42
T344
S
P
P
S
S
L
T
T
D
P
S
Q
S
L
L
Site 43
S347
S
S
L
T
T
D
P
S
Q
S
L
L
S
L
E
Site 44
S349
L
T
T
D
P
S
Q
S
L
L
S
L
E
Q
E
Site 45
S352
D
P
S
Q
S
L
L
S
L
E
Q
E
P
L
L
Site 46
S360
L
E
Q
E
P
L
L
S
R
M
G
S
L
R
A
Site 47
S364
P
L
L
S
R
M
G
S
L
R
A
P
V
D
E
Site 48
S375
P
V
D
E
D
R
L
S
P
L
V
A
A
D
S
Site 49
S382
S
P
L
V
A
A
D
S
L
L
E
H
V
R
E
Site 50
S392
E
H
V
R
E
D
F
S
G
L
L
P
E
E
F
Site 51
S401
L
L
P
E
E
F
I
S
L
S
P
P
H
E
A
Site 52
S403
P
E
E
F
I
S
L
S
P
P
H
E
A
L
D
Site 53
Y411
P
P
H
E
A
L
D
Y
H
F
G
L
E
E
G
Site 54
T433
D
C
D
F
G
D
L
T
P
L
D
F
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation