PhosphoNET

           
Protein Info 
   
Short Name:  EWS
Full Name:  RNA-binding protein EWS
Alias:  Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1 (EWS); Ewing sarcoma breakpoint region 1 protein; EWS oncogene; EWSH; EWSR1
Type:  Transcription, coactivator/corepressor; RNA binding protein
Mass (Da):  68478
Number AA:  656
UniProt ID:  Q01844
International Prot ID:  IPI00009841
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005634  GO:0005886 Uniprot OncoNet
Molecular Function:  GO:0003723  GO:0005516  GO:0000166 PhosphoSite+ KinaseNET
Biological Process:  GO:0045449  GO:0006350   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S7_MASTDYSTYSQAAA
Site 2S10STDYSTYSQAAAQQG
Site 3T22QQGYSAYTAQPTQGY
Site 4S40TQAYGQQSYGTYGQP
Site 5Y44GQQSYGTYGQPTDVS
Site 6S51YGQPTDVSYTQAQTT
Site 7Y52GQPTDVSYTQAQTTA
Site 8Y66ATYGQTAYATSYGQP
Site 9S69GQTAYATSYGQPPTG
Site 10Y70QTAYATSYGQPPTGY
Site 11T75TSYGQPPTGYTTPTA
Site 12Y77YGQPPTGYTTPTAPQ
Site 13T79QPPTGYTTPTAPQAY
Site 14Y86TPTAPQAYSQPVQGY
Site 15S87PTAPQAYSQPVQGYG
Site 16Y98QGYGTGAYDTTTATV
Site 17T100YGTGAYDTTTATVTT
Site 18T101GTGAYDTTTATVTTT
Site 19T102TGAYDTTTATVTTTQ
Site 20T104AYDTTTATVTTTQAS
Site 21S111TVTTTQASYAAQSAY
Site 22T120AAQSAYGTQPAYPAY
Site 23Y124AYGTQPAYPAYGQQP
Site 24T148DGNKPTETSQPQSST
Site 25S149GNKPTETSQPQSSTG
Site 26S153TETSQPQSSTGGYNQ
Site 27S154ETSQPQSSTGGYNQP
Site 28Y158PQSSTGGYNQPSLGY
Site 29S162TGGYNQPSLGYGQSN
Site 30S168PSLGYGQSNYSYPQV
Site 31Y170LGYGQSNYSYPQVPG
Site 32S171GYGQSNYSYPQVPGS
Site 33Y172YGQSNYSYPQVPGSY
Site 34S178SYPQVPGSYPMQPVT
Site 35T185SYPMQPVTAPPSYPP
Site 36S189QPVTAPPSYPPTSYS
Site 37Y190PVTAPPSYPPTSYSS
Site 38T193APPSYPPTSYSSTQP
Site 39S194PPSYPPTSYSSTQPT
Site 40S196SYPPTSYSSTQPTSY
Site 41T198PPTSYSSTQPTSYDQ
Site 42T201SYSSTQPTSYDQSSY
Site 43S202YSSTQPTSYDQSSYS
Site 44Y203SSTQPTSYDQSSYSQ
Site 45S206QPTSYDQSSYSQQNT
Site 46S207PTSYDQSSYSQQNTY
Site 47S209SYDQSSYSQQNTYGQ
Site 48T213SSYSQQNTYGQPSSY
Site 49Y214SYSQQNTYGQPSSYG
Site 50S219NTYGQPSSYGQQSSY
Site 51Y220TYGQPSSYGQQSSYG
Site 52S224PSSYGQQSSYGQQSS
Site 53S225SSYGQQSSYGQQSSY
Site 54Y226SYGQQSSYGQQSSYG
Site 55S231SSYGQQSSYGQQPPT
Site 56Y232SYGQQSSYGQQPPTS
Site 57T238SYGQQPPTSYPPQTG
Site 58S239YGQQPPTSYPPQTGS
Site 59Y240GQQPPTSYPPQTGSY
Site 60T244PTSYPPQTGSYSQAP
Site 61S246SYPPQTGSYSQAPSQ
Site 62S248PPQTGSYSQAPSQYS
Site 63S252GSYSQAPSQYSQQSS
Site 64Y254YSQAPSQYSQQSSSY
Site 65S255SQAPSQYSQQSSSYG
Site 66S258PSQYSQQSSSYGQQS
Site 67S259SQYSQQSSSYGQQSS
Site 68S260QYSQQSSSYGQQSSF
Site 69Y261YSQQSSSYGQQSSFR
Site 70S265SSSYGQQSSFRQDHP
Site 71S266SSYGQQSSFRQDHPS
Site 72S273SFRQDHPSSMGVYGQ
Site 73S274FRQDHPSSMGVYGQE
Site 74Y278HPSSMGVYGQESGGF
Site 75S282MGVYGQESGGFSGPG
Site 76S286GQESGGFSGPGENRS
Site 77S293SGPGENRSMSGPDNR
Site 78S295PGENRSMSGPDNRGR
Site 79S313GFDRGGMSRGGRGGG
Site 80S326GGRGGMGSAGERGGF
Site 81S358PVDPDEDSDNSAIYV
Site 82S361PDEDSDNSAIYVQGL
Site 83Y364DSDNSAIYVQGLNDS
Site 84S371YVQGLNDSVTLDDLA
Site 85T373QGLNDSVTLDDLADF
Site 86Y401GQPMIHIYLDKETGK
Site 87T406HIYLDKETGKPKGDA
Site 88T414GKPKGDATVSYEDPP
Site 89S416PKGDATVSYEDPPTA
Site 90Y417KGDATVSYEDPPTAK
Site 91T422VSYEDPPTAKAAVEW
Site 92S443QGSKLKVSLARKKPP
Site 93S453RKKPPMNSMRGGLPP
Site 94S505PPRGPRGSRGNPSGG
Site 95S510RGSRGNPSGGGNVQH
Site 96Y656QERRDRPY_______
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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