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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GUCY1B3
Full Name:
Guanylate cyclase soluble subunit beta-1
Alias:
Guanylate cyclase soluble subunit beta-3;Soluble guanylate cyclase small subunit
Type:
Enzyme, cyclic nucleotide synthesis, guanylyl cyclase
Mass (Da):
70514
Number AA:
619
UniProt ID:
Q02153
International Prot ID:
IPI00289033
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008074
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0004383
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0008015
GO:0006182
GO:0007263
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
E
L
L
V
I
R
N
Y
G
P
E
V
W
E
D
Site 2
Y43
Q
F
L
V
R
I
I
Y
D
D
S
K
T
Y
D
Site 3
S46
V
R
I
I
Y
D
D
S
K
T
Y
D
L
V
A
Site 4
T85
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Site 5
Y112
H
D
H
L
A
T
I
Y
P
G
M
R
A
P
S
Site 6
S119
Y
P
G
M
R
A
P
S
F
R
C
T
D
A
E
Site 7
T123
R
A
P
S
F
R
C
T
D
A
E
K
G
K
G
Site 8
Y135
G
K
G
L
I
L
H
Y
Y
S
E
R
E
G
L
Site 9
Y136
K
G
L
I
L
H
Y
Y
S
E
R
E
G
L
Q
Site 10
S137
G
L
I
L
H
Y
Y
S
E
R
E
G
L
Q
D
Site 11
T177
R
N
E
E
C
D
H
T
Q
F
L
I
E
E
K
Site 12
S186
F
L
I
E
E
K
E
S
K
E
E
D
F
Y
E
Site 13
Y192
E
S
K
E
E
D
F
Y
E
D
L
D
R
F
E
Site 14
T203
D
R
F
E
E
N
G
T
Q
E
S
R
I
S
P
Site 15
S209
G
T
Q
E
S
R
I
S
P
Y
T
F
C
K
A
Site 16
T212
E
S
R
I
S
P
Y
T
F
C
K
A
F
P
F
Site 17
T297
L
E
C
E
D
E
L
T
G
T
E
I
S
C
L
Site 18
T299
C
E
D
E
L
T
G
T
E
I
S
C
L
R
L
Site 19
S302
E
L
T
G
T
E
I
S
C
L
R
L
K
G
Q
Site 20
Y312
R
L
K
G
Q
M
I
Y
L
P
E
A
D
S
I
Site 21
T334
V
M
N
L
D
D
L
T
R
R
G
L
Y
L
S
Site 22
Y339
D
L
T
R
R
G
L
Y
L
S
D
I
P
L
H
Site 23
S341
T
R
R
G
L
Y
L
S
D
I
P
L
H
D
A
Site 24
Y363
G
E
Q
F
R
E
E
Y
K
L
T
Q
E
L
E
Site 25
T366
F
R
E
E
Y
K
L
T
Q
E
L
E
I
L
T
Site 26
T373
T
Q
E
L
E
I
L
T
D
R
L
Q
L
T
L
Site 27
T379
L
T
D
R
L
Q
L
T
L
R
A
L
E
D
E
Site 28
T390
L
E
D
E
K
K
K
T
D
T
L
L
Y
S
V
Site 29
T392
D
E
K
K
K
T
D
T
L
L
Y
S
V
L
P
Site 30
Y395
K
K
T
D
T
L
L
Y
S
V
L
P
P
S
V
Site 31
S401
L
Y
S
V
L
P
P
S
V
A
N
E
L
R
H
Site 32
Y417
R
P
V
P
A
K
R
Y
D
N
V
T
I
L
F
Site 33
S435
V
G
F
N
A
F
C
S
K
H
A
S
G
E
G
Site 34
S439
A
F
C
S
K
H
A
S
G
E
G
A
M
K
I
Site 35
Y454
V
N
L
L
N
D
L
Y
T
R
F
D
T
L
T
Site 36
T455
N
L
L
N
D
L
Y
T
R
F
D
T
L
T
D
Site 37
T459
D
L
Y
T
R
F
D
T
L
T
D
S
R
K
N
Site 38
T461
Y
T
R
F
D
T
L
T
D
S
R
K
N
P
F
Site 39
S463
R
F
D
T
L
T
D
S
R
K
N
P
F
V
Y
Site 40
Y470
S
R
K
N
P
F
V
Y
K
V
E
T
V
G
D
Site 41
T481
T
V
G
D
K
Y
M
T
V
S
G
L
P
E
P
Site 42
S483
G
D
K
Y
M
T
V
S
G
L
P
E
P
C
I
Site 43
T520
D
G
E
S
V
Q
I
T
I
G
I
H
T
G
E
Site 44
Y540
I
G
Q
R
M
P
R
Y
C
L
F
G
N
T
V
Site 45
T546
R
Y
C
L
F
G
N
T
V
N
L
T
S
R
T
Site 46
T550
F
G
N
T
V
N
L
T
S
R
T
E
T
T
G
Site 47
T555
N
L
T
S
R
T
E
T
T
G
E
K
G
K
I
Site 48
S565
E
K
G
K
I
N
V
S
E
Y
T
Y
R
C
L
Site 49
Y567
G
K
I
N
V
S
E
Y
T
Y
R
C
L
M
S
Site 50
T568
K
I
N
V
S
E
Y
T
Y
R
C
L
M
S
P
Site 51
Y569
I
N
V
S
E
Y
T
Y
R
C
L
M
S
P
E
Site 52
S574
Y
T
Y
R
C
L
M
S
P
E
N
S
D
P
Q
Site 53
S578
C
L
M
S
P
E
N
S
D
P
Q
F
H
L
E
Site 54
S591
L
E
H
R
G
P
V
S
M
K
G
K
K
E
P
Site 55
T609
W
F
L
S
R
K
N
T
G
T
E
E
T
K
Q
Site 56
T611
L
S
R
K
N
T
G
T
E
E
T
K
Q
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation