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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN12
Full Name:
Tyrosine-protein phosphatase non-receptor type 12
Alias:
EC 3.1.3.48; Protein-tyrosine phosphatase G1; PTN12; PTNC; PTPG1; PTP-PEST
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
88120
Number AA:
780
UniProt ID:
Q05209
International Prot ID:
IPI00289082
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0004726
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
Q
R
V
Q
A
M
K
S
P
D
H
N
G
E
D
Site 2
S39
F
M
R
L
R
R
L
S
T
K
Y
R
T
E
K
Site 3
T40
M
R
L
R
R
L
S
T
K
Y
R
T
E
K
I
Site 4
Y42
L
R
R
L
S
T
K
Y
R
T
E
K
I
Y
P
Site 5
Y48
K
Y
R
T
E
K
I
Y
P
T
A
T
G
E
K
Site 6
Y64
E
N
V
K
K
N
R
Y
K
D
I
L
P
F
D
Site 7
S73
D
I
L
P
F
D
H
S
R
V
K
L
T
L
K
Site 8
T81
R
V
K
L
T
L
K
T
P
S
Q
D
S
D
Y
Site 9
S83
K
L
T
L
K
T
P
S
Q
D
S
D
Y
I
N
Site 10
S86
L
K
T
P
S
Q
D
S
D
Y
I
N
A
N
F
Site 11
Y88
T
P
S
Q
D
S
D
Y
I
N
A
N
F
I
K
Site 12
Y146
G
R
K
K
C
E
R
Y
W
P
L
Y
G
E
D
Site 13
Y150
C
E
R
Y
W
P
L
Y
G
E
D
P
I
T
F
Site 14
S163
T
F
A
P
F
K
I
S
C
E
D
E
Q
A
R
Site 15
T171
C
E
D
E
Q
A
R
T
D
Y
F
I
R
T
L
Site 16
Y173
D
E
Q
A
R
T
D
Y
F
I
R
T
L
L
L
Site 17
S186
L
L
E
F
Q
N
E
S
R
R
L
Y
Q
F
H
Site 18
Y190
Q
N
E
S
R
R
L
Y
Q
F
H
Y
V
N
W
Site 19
S204
W
P
D
H
D
V
P
S
S
F
D
S
I
L
D
Site 20
S205
P
D
H
D
V
P
S
S
F
D
S
I
L
D
M
Site 21
S214
D
S
I
L
D
M
I
S
L
M
R
K
Y
Q
E
Site 22
Y219
M
I
S
L
M
R
K
Y
Q
E
H
E
D
V
P
Site 23
T271
N
L
I
Q
E
M
R
T
Q
R
H
S
A
V
Q
Site 24
S275
E
M
R
T
Q
R
H
S
A
V
Q
T
K
E
Q
Site 25
T279
Q
R
H
S
A
V
Q
T
K
E
Q
Y
E
L
V
Site 26
Y301
F
E
K
Q
L
Q
L
Y
E
I
H
G
A
Q
K
Site 27
T318
D
G
V
N
E
I
N
T
E
N
M
I
S
S
I
Site 28
S323
I
N
T
E
N
M
I
S
S
I
E
P
E
K
Q
Site 29
S324
N
T
E
N
M
I
S
S
I
E
P
E
K
Q
D
Site 30
S332
I
E
P
E
K
Q
D
S
P
P
P
K
P
P
R
Site 31
T340
P
P
P
K
P
P
R
T
R
S
C
L
V
E
G
Site 32
S342
P
K
P
P
R
T
R
S
C
L
V
E
G
D
A
Site 33
T367
H
P
V
P
P
I
L
T
P
S
P
P
S
A
F
Site 34
T376
S
P
P
S
A
F
P
T
V
T
T
V
W
Q
D
Site 35
Y387
V
W
Q
D
N
D
R
Y
H
P
K
P
V
L
H
Site 36
S397
K
P
V
L
H
M
V
S
S
E
Q
H
S
A
D
Site 37
S398
P
V
L
H
M
V
S
S
E
Q
H
S
A
D
L
Site 38
S402
M
V
S
S
E
Q
H
S
A
D
L
N
R
N
Y
Site 39
Y409
S
A
D
L
N
R
N
Y
S
K
S
T
E
L
P
Site 40
S410
A
D
L
N
R
N
Y
S
K
S
T
E
L
P
G
Site 41
S412
L
N
R
N
Y
S
K
S
T
E
L
P
G
K
N
Site 42
S435
K
K
L
E
R
N
L
S
F
E
I
K
K
V
P
Site 43
S449
P
L
Q
E
G
P
K
S
F
D
G
N
T
L
L
Site 44
T454
P
K
S
F
D
G
N
T
L
L
N
R
G
H
A
Site 45
S468
A
I
K
I
K
S
A
S
P
C
I
A
D
K
I
Site 46
S476
P
C
I
A
D
K
I
S
K
P
Q
E
L
S
S
Site 47
S483
S
K
P
Q
E
L
S
S
D
L
N
V
G
D
T
Site 48
T490
S
D
L
N
V
G
D
T
S
Q
N
S
C
V
D
Site 49
S491
D
L
N
V
G
D
T
S
Q
N
S
C
V
D
C
Site 50
S494
V
G
D
T
S
Q
N
S
C
V
D
C
S
V
T
Site 51
T501
S
C
V
D
C
S
V
T
Q
S
N
K
V
S
V
Site 52
S503
V
D
C
S
V
T
Q
S
N
K
V
S
V
T
P
Site 53
S507
V
T
Q
S
N
K
V
S
V
T
P
P
E
E
S
Site 54
T509
Q
S
N
K
V
S
V
T
P
P
E
E
S
Q
N
Site 55
S514
S
V
T
P
P
E
E
S
Q
N
S
D
T
P
P
Site 56
S517
P
P
E
E
S
Q
N
S
D
T
P
P
R
P
D
Site 57
T519
E
E
S
Q
N
S
D
T
P
P
R
P
D
R
L
Site 58
S551
A
I
P
I
P
D
L
S
E
G
N
S
S
D
I
Site 59
S555
P
D
L
S
E
G
N
S
S
D
I
N
Y
Q
T
Site 60
S556
D
L
S
E
G
N
S
S
D
I
N
Y
Q
T
R
Site 61
Y560
G
N
S
S
D
I
N
Y
Q
T
R
K
T
V
S
Site 62
T565
I
N
Y
Q
T
R
K
T
V
S
L
T
P
S
P
Site 63
S567
Y
Q
T
R
K
T
V
S
L
T
P
S
P
T
T
Site 64
T569
T
R
K
T
V
S
L
T
P
S
P
T
T
Q
V
Site 65
S571
K
T
V
S
L
T
P
S
P
T
T
Q
V
E
T
Site 66
T573
V
S
L
T
P
S
P
T
T
Q
V
E
T
P
D
Site 67
T574
S
L
T
P
S
P
T
T
Q
V
E
T
P
D
L
Site 68
T578
S
P
T
T
Q
V
E
T
P
D
L
V
D
H
D
Site 69
T587
D
L
V
D
H
D
N
T
S
P
L
F
R
T
P
Site 70
S588
L
V
D
H
D
N
T
S
P
L
F
R
T
P
L
Site 71
T593
N
T
S
P
L
F
R
T
P
L
S
F
T
N
P
Site 72
S596
P
L
F
R
T
P
L
S
F
T
N
P
L
H
S
Site 73
S603
S
F
T
N
P
L
H
S
D
D
S
D
S
D
E
Site 74
S606
N
P
L
H
S
D
D
S
D
S
D
E
R
N
S
Site 75
S608
L
H
S
D
D
S
D
S
D
E
R
N
S
D
G
Site 76
S613
S
D
S
D
E
R
N
S
D
G
A
V
T
Q
N
Site 77
S632
S
T
A
S
A
T
V
S
A
A
T
S
T
E
S
Site 78
S636
A
T
V
S
A
A
T
S
T
E
S
I
S
T
R
Site 79
T637
T
V
S
A
A
T
S
T
E
S
I
S
T
R
K
Site 80
S641
A
T
S
T
E
S
I
S
T
R
K
V
L
P
M
Site 81
T642
T
S
T
E
S
I
S
T
R
K
V
L
P
M
S
Site 82
S649
T
R
K
V
L
P
M
S
I
A
R
H
N
I
A
Site 83
S670
A
E
K
D
V
D
V
S
E
D
S
P
P
P
L
Site 84
S673
D
V
D
V
S
E
D
S
P
P
P
L
P
E
R
Site 85
T681
P
P
P
L
P
E
R
T
P
E
S
F
V
L
A
Site 86
S684
L
P
E
R
T
P
E
S
F
V
L
A
S
E
H
Site 87
S689
P
E
S
F
V
L
A
S
E
H
N
T
P
V
R
Site 88
T693
V
L
A
S
E
H
N
T
P
V
R
S
E
W
S
Site 89
S697
E
H
N
T
P
V
R
S
E
W
S
E
L
Q
S
Site 90
S704
S
E
W
S
E
L
Q
S
Q
E
R
S
E
Q
K
Site 91
S708
E
L
Q
S
Q
E
R
S
E
Q
K
K
S
E
G
Site 92
S713
E
R
S
E
Q
K
K
S
E
G
L
I
T
S
E
Site 93
T718
K
K
S
E
G
L
I
T
S
E
N
E
K
C
D
Site 94
S719
K
S
E
G
L
I
T
S
E
N
E
K
C
D
H
Site 95
T742
M
C
I
E
C
P
P
T
F
S
D
K
R
E
Q
Site 96
S744
I
E
C
P
P
T
F
S
D
K
R
E
Q
I
S
Site 97
T755
E
Q
I
S
E
N
P
T
E
A
T
D
I
G
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation