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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNAseL
Full Name:
2-5A-dependent ribonuclease
Alias:
2-5A-dependent ribonuclease; 2-5A-dependent RNase; EC 3.1.26.-; PRCA1; Ribonuclease 4; Ribonuclease L; RN5A; RNase L; RNS4
Type:
EC 3.1.26.-; Ribonuclease; Protein kinase, Ser/Thr (non-receptor); Other group; Other-Unique family
Mass (Da):
83533
Number AA:
741
UniProt ID:
Q05823
International Prot ID:
IPI00015864
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016891
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0006397
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
N
P
Q
E
G
P
T
S
S
S
G
R
R
A
A
Site 2
S16
P
Q
E
G
P
T
S
S
S
G
R
R
A
A
V
Site 3
S17
Q
E
G
P
T
S
S
S
G
R
R
A
A
V
E
Site 4
T61
Q
E
E
E
G
G
W
T
P
L
H
N
A
V
Q
Site 5
S113
K
L
L
K
L
F
L
S
K
G
A
D
V
N
E
Site 6
Y124
D
V
N
E
C
D
F
Y
G
F
T
A
F
M
E
Site 7
Y145
V
K
A
L
K
F
L
Y
K
R
G
A
N
V
N
Site 8
T157
N
V
N
L
R
R
K
T
K
E
D
Q
E
R
L
Site 9
S216
A
L
L
S
S
D
D
S
D
V
E
A
I
T
H
Site 10
T241
V
R
G
E
R
G
K
T
P
L
I
L
A
V
E
Site 11
T269
E
H
I
E
I
N
D
T
D
S
D
G
K
T
A
Site 12
S271
I
E
I
N
D
T
D
S
D
G
K
T
A
L
L
Site 13
T275
D
T
D
S
D
G
K
T
A
L
L
L
A
V
E
Site 14
T307
D
C
G
D
L
V
M
T
A
R
R
N
Y
D
H
Site 15
Y312
V
M
T
A
R
R
N
Y
D
H
S
L
V
K
V
Site 16
S315
A
R
R
N
Y
D
H
S
L
V
K
V
L
L
S
Site 17
S340
A
E
D
W
K
P
Q
S
S
H
W
G
A
A
L
Site 18
Y354
L
K
D
L
H
R
I
Y
R
P
M
I
G
K
L
Site 19
Y369
K
F
F
I
D
E
K
Y
K
I
A
D
T
S
E
Site 20
T374
E
K
Y
K
I
A
D
T
S
E
G
G
I
Y
L
Site 21
S375
K
Y
K
I
A
D
T
S
E
G
G
I
Y
L
G
Site 22
Y380
D
T
S
E
G
G
I
Y
L
G
F
Y
E
K
Q
Site 23
T393
K
Q
E
V
A
V
K
T
F
C
E
G
S
P
R
Site 24
S398
V
K
T
F
C
E
G
S
P
R
A
Q
R
E
V
Site 25
S406
P
R
A
Q
R
E
V
S
C
L
Q
S
S
R
E
Site 26
S410
R
E
V
S
C
L
Q
S
S
R
E
N
S
H
L
Site 27
S411
E
V
S
C
L
Q
S
S
R
E
N
S
H
L
V
Site 28
S415
L
Q
S
S
R
E
N
S
H
L
V
T
F
Y
G
Site 29
T419
R
E
N
S
H
L
V
T
F
Y
G
S
E
S
H
Site 30
Y421
N
S
H
L
V
T
F
Y
G
S
E
S
H
R
G
Site 31
S423
H
L
V
T
F
Y
G
S
E
S
H
R
G
H
L
Site 32
S425
V
T
F
Y
G
S
E
S
H
R
G
H
L
F
V
Site 33
T482
L
H
L
S
C
G
Y
T
H
Q
D
L
Q
P
Q
Site 34
S538
V
V
K
K
G
S
I
S
F
E
D
L
K
A
Q
Site 35
S554
N
E
E
V
V
Q
L
S
P
D
E
E
T
K
D
Site 36
S578
E
H
V
R
D
C
L
S
D
L
L
G
H
P
F
Site 37
T588
L
G
H
P
F
F
W
T
W
E
S
R
Y
R
T
Site 38
T595
T
W
E
S
R
Y
R
T
L
R
N
V
G
N
E
Site 39
S603
L
R
N
V
G
N
E
S
D
I
K
T
R
K
S
Site 40
T607
G
N
E
S
D
I
K
T
R
K
S
E
S
E
I
Site 41
S610
S
D
I
K
T
R
K
S
E
S
E
I
L
R
L
Site 42
S612
I
K
T
R
K
S
E
S
E
I
L
R
L
L
Q
Site 43
S623
R
L
L
Q
P
G
P
S
E
H
S
K
S
F
D
Site 44
S628
G
P
S
E
H
S
K
S
F
D
K
W
T
T
K
Site 45
Y648
M
K
K
M
N
K
F
Y
E
K
R
G
N
F
Y
Site 46
Y655
Y
E
K
R
G
N
F
Y
Q
N
T
V
G
D
L
Site 47
T658
R
G
N
F
Y
Q
N
T
V
G
D
L
L
K
F
Site 48
S689
K
L
K
I
G
D
P
S
L
Y
F
Q
K
T
F
Site 49
Y691
K
I
G
D
P
S
L
Y
F
Q
K
T
F
P
D
Site 50
Y704
P
D
L
V
I
Y
V
Y
T
K
L
Q
N
T
E
Site 51
Y712
T
K
L
Q
N
T
E
Y
R
K
H
F
P
Q
T
Site 52
T719
Y
R
K
H
F
P
Q
T
H
S
P
N
K
P
Q
Site 53
S721
K
H
F
P
Q
T
H
S
P
N
K
P
Q
C
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation