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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEF2C
Full Name:
Myocyte-specific enhancer factor 2C
Alias:
Myocyte-specific enhancer factor 2C: Myocyte-specific enhancer factor 2C: Myocyte-specific enhancer factor 2C
Type:
Transcription protein
Mass (Da):
51221
Number AA:
473
UniProt ID:
Q06413
International Prot ID:
IPI00289092
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0005515
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0030154
GO:0007517
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
D
E
R
N
R
Q
V
T
F
T
K
R
K
F
G
Site 2
T22
R
N
R
Q
V
T
F
T
K
R
K
F
G
L
M
Site 3
Y57
S
T
N
K
L
F
Q
Y
A
S
T
D
M
D
K
Site 4
S59
N
K
L
F
Q
Y
A
S
T
D
M
D
K
V
L
Site 5
Y69
M
D
K
V
L
L
K
Y
T
E
Y
N
E
P
H
Site 6
T70
D
K
V
L
L
K
Y
T
E
Y
N
E
P
H
E
Site 7
Y72
V
L
L
K
Y
T
E
Y
N
E
P
H
E
S
R
Site 8
S78
E
Y
N
E
P
H
E
S
R
T
N
S
D
I
V
Site 9
T80
N
E
P
H
E
S
R
T
N
S
D
I
V
E
T
Site 10
S82
P
H
E
S
R
T
N
S
D
I
V
E
T
L
R
Site 11
T87
T
N
S
D
I
V
E
T
L
R
K
K
G
L
N
Site 12
S98
K
G
L
N
G
C
D
S
P
D
P
D
A
D
D
Site 13
S106
P
D
P
D
A
D
D
S
V
G
H
S
P
E
S
Site 14
S110
A
D
D
S
V
G
H
S
P
E
S
E
D
K
Y
Site 15
S113
S
V
G
H
S
P
E
S
E
D
K
Y
R
K
I
Site 16
Y117
S
P
E
S
E
D
K
Y
R
K
I
N
E
D
I
Site 17
S146
P
N
F
E
M
P
V
S
I
P
V
S
S
H
N
Site 18
S154
I
P
V
S
S
H
N
S
L
V
Y
S
N
P
V
Site 19
Y157
S
S
H
N
S
L
V
Y
S
N
P
V
S
S
L
Site 20
S158
S
H
N
S
L
V
Y
S
N
P
V
S
S
L
G
Site 21
S162
L
V
Y
S
N
P
V
S
S
L
G
N
P
N
L
Site 22
S163
V
Y
S
N
P
V
S
S
L
G
N
P
N
L
L
Site 23
S176
L
L
P
L
A
H
P
S
L
Q
R
N
S
M
S
Site 24
S181
H
P
S
L
Q
R
N
S
M
S
P
G
V
T
H
Site 25
S183
S
L
Q
R
N
S
M
S
P
G
V
T
H
R
P
Site 26
T187
N
S
M
S
P
G
V
T
H
R
P
P
S
A
G
Site 27
S192
G
V
T
H
R
P
P
S
A
G
N
T
G
G
L
Site 28
T196
R
P
P
S
A
G
N
T
G
G
L
M
G
G
D
Site 29
S206
L
M
G
G
D
L
T
S
G
A
G
T
S
A
G
Site 30
T210
D
L
T
S
G
A
G
T
S
A
G
N
G
Y
G
Site 31
Y216
G
T
S
A
G
N
G
Y
G
N
P
R
N
S
P
Site 32
S222
G
Y
G
N
P
R
N
S
P
G
L
L
V
S
P
Site 33
S228
N
S
P
G
L
L
V
S
P
G
N
L
N
K
N
Site 34
S240
N
K
N
M
Q
A
K
S
P
P
P
M
N
L
G
Site 35
S263
R
V
L
I
P
P
G
S
K
N
T
M
P
S
V
Site 36
S269
G
S
K
N
T
M
P
S
V
S
E
D
V
D
L
Site 37
S271
K
N
T
M
P
S
V
S
E
D
V
D
L
L
L
Site 38
S285
L
N
Q
R
I
N
N
S
Q
S
A
Q
S
L
A
Site 39
S287
Q
R
I
N
N
S
Q
S
A
Q
S
L
A
T
P
Site 40
T293
Q
S
A
Q
S
L
A
T
P
V
V
S
V
A
T
Site 41
T300
T
P
V
V
S
V
A
T
P
T
L
P
G
Q
G
Site 42
Y311
P
G
Q
G
M
G
G
Y
P
S
A
I
S
T
T
Site 43
S313
Q
G
M
G
G
Y
P
S
A
I
S
T
T
Y
G
Site 44
S316
G
G
Y
P
S
A
I
S
T
T
Y
G
T
E
Y
Site 45
T317
G
Y
P
S
A
I
S
T
T
Y
G
T
E
Y
S
Site 46
Y323
S
T
T
Y
G
T
E
Y
S
L
S
S
A
D
L
Site 47
S324
T
T
Y
G
T
E
Y
S
L
S
S
A
D
L
S
Site 48
S326
Y
G
T
E
Y
S
L
S
S
A
D
L
S
S
L
Site 49
S327
G
T
E
Y
S
L
S
S
A
D
L
S
S
L
S
Site 50
S331
S
L
S
S
A
D
L
S
S
L
S
G
F
N
T
Site 51
S334
S
A
D
L
S
S
L
S
G
F
N
T
A
S
A
Site 52
T338
S
S
L
S
G
F
N
T
A
S
A
L
H
L
G
Site 53
S346
A
S
A
L
H
L
G
S
V
T
G
W
Q
Q
Q
Site 54
S361
H
L
H
N
M
P
P
S
A
L
S
Q
L
G
A
Site 55
S364
N
M
P
P
S
A
L
S
Q
L
G
A
C
T
S
Site 56
S371
S
Q
L
G
A
C
T
S
T
H
L
S
Q
S
S
Site 57
S375
A
C
T
S
T
H
L
S
Q
S
S
N
L
S
L
Site 58
S377
T
S
T
H
L
S
Q
S
S
N
L
S
L
P
S
Site 59
S378
S
T
H
L
S
Q
S
S
N
L
S
L
P
S
T
Site 60
S381
L
S
Q
S
S
N
L
S
L
P
S
T
Q
S
L
Site 61
S384
S
S
N
L
S
L
P
S
T
Q
S
L
N
I
K
Site 62
T385
S
N
L
S
L
P
S
T
Q
S
L
N
I
K
S
Site 63
S387
L
S
L
P
S
T
Q
S
L
N
I
K
S
E
P
Site 64
S392
T
Q
S
L
N
I
K
S
E
P
V
S
P
P
R
Site 65
S396
N
I
K
S
E
P
V
S
P
P
R
D
R
T
T
Site 66
T402
V
S
P
P
R
D
R
T
T
T
P
S
R
Y
P
Site 67
T403
S
P
P
R
D
R
T
T
T
P
S
R
Y
P
Q
Site 68
T404
P
P
R
D
R
T
T
T
P
S
R
Y
P
Q
H
Site 69
S406
R
D
R
T
T
T
P
S
R
Y
P
Q
H
T
R
Site 70
Y408
R
T
T
T
P
S
R
Y
P
Q
H
T
R
H
E
Site 71
T412
P
S
R
Y
P
Q
H
T
R
H
E
A
G
R
S
Site 72
S419
T
R
H
E
A
G
R
S
P
V
D
S
L
S
S
Site 73
S423
A
G
R
S
P
V
D
S
L
S
S
C
S
S
S
Site 74
S425
R
S
P
V
D
S
L
S
S
C
S
S
S
Y
D
Site 75
S426
S
P
V
D
S
L
S
S
C
S
S
S
Y
D
G
Site 76
S428
V
D
S
L
S
S
C
S
S
S
Y
D
G
S
D
Site 77
S429
D
S
L
S
S
C
S
S
S
Y
D
G
S
D
R
Site 78
S430
S
L
S
S
C
S
S
S
Y
D
G
S
D
R
E
Site 79
S434
C
S
S
S
Y
D
G
S
D
R
E
D
H
R
N
Site 80
S445
D
H
R
N
E
F
H
S
P
I
G
L
T
R
P
Site 81
S453
P
I
G
L
T
R
P
S
P
D
E
R
E
S
P
Site 82
S459
P
S
P
D
E
R
E
S
P
S
V
K
R
M
R
Site 83
S461
P
D
E
R
E
S
P
S
V
K
R
M
R
L
S
Site 84
S468
S
V
K
R
M
R
L
S
E
G
W
A
T
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation