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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE4B
Full Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Alias:
CN4B; DPDE4; PDE32; Phosphodiesterase 4B, cAMP-specific; Phosphodiesterase E4 dunce
Type:
Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.17
Mass (Da):
83343
Number AA:
736
UniProt ID:
Q07343
International Prot ID:
IPI00016604
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005626
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0004115
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
A
D
D
N
V
K
D
Y
F
E
C
S
L
S
K
Site 2
S23
V
K
D
Y
F
E
C
S
L
S
K
S
Y
S
S
Site 3
S25
D
Y
F
E
C
S
L
S
K
S
Y
S
S
S
S
Site 4
S27
F
E
C
S
L
S
K
S
Y
S
S
S
S
N
T
Site 5
S29
C
S
L
S
K
S
Y
S
S
S
S
N
T
L
G
Site 6
S30
S
L
S
K
S
Y
S
S
S
S
N
T
L
G
I
Site 7
S31
L
S
K
S
Y
S
S
S
S
N
T
L
G
I
D
Site 8
S32
S
K
S
Y
S
S
S
S
N
T
L
G
I
D
L
Site 9
T34
S
Y
S
S
S
S
N
T
L
G
I
D
L
W
R
Site 10
S47
W
R
G
R
R
C
C
S
G
N
L
Q
L
P
P
Site 11
S56
N
L
Q
L
P
P
L
S
Q
R
Q
S
E
R
A
Site 12
S60
P
P
L
S
Q
R
Q
S
E
R
A
R
T
P
E
Site 13
T65
R
Q
S
E
R
A
R
T
P
E
G
D
G
I
S
Site 14
S72
T
P
E
G
D
G
I
S
R
P
T
T
L
P
L
Site 15
T75
G
D
G
I
S
R
P
T
T
L
P
L
T
T
L
Site 16
T76
D
G
I
S
R
P
T
T
L
P
L
T
T
L
P
Site 17
S102
F
D
V
E
N
G
P
S
P
G
R
S
P
L
D
Site 18
S106
N
G
P
S
P
G
R
S
P
L
D
P
Q
A
S
Site 19
T123
A
G
L
V
L
H
A
T
F
P
G
H
S
Q
R
Site 20
S128
H
A
T
F
P
G
H
S
Q
R
R
E
S
F
L
Site 21
S133
G
H
S
Q
R
R
E
S
F
L
Y
R
S
D
S
Site 22
Y136
Q
R
R
E
S
F
L
Y
R
S
D
S
D
Y
D
Site 23
S138
R
E
S
F
L
Y
R
S
D
S
D
Y
D
L
S
Site 24
S140
S
F
L
Y
R
S
D
S
D
Y
D
L
S
P
K
Site 25
Y142
L
Y
R
S
D
S
D
Y
D
L
S
P
K
A
M
Site 26
S145
S
D
S
D
Y
D
L
S
P
K
A
M
S
R
N
Site 27
S150
D
L
S
P
K
A
M
S
R
N
S
S
L
P
S
Site 28
S153
P
K
A
M
S
R
N
S
S
L
P
S
E
Q
H
Site 29
S154
K
A
M
S
R
N
S
S
L
P
S
E
Q
H
G
Site 30
S157
S
R
N
S
S
L
P
S
E
Q
H
G
D
D
L
Site 31
T167
H
G
D
D
L
I
V
T
P
F
A
Q
V
L
A
Site 32
S175
P
F
A
Q
V
L
A
S
L
R
S
V
R
N
N
Site 33
T184
R
S
V
R
N
N
F
T
I
L
T
N
L
H
G
Site 34
T187
R
N
N
F
T
I
L
T
N
L
H
G
T
S
N
Site 35
S193
L
T
N
L
H
G
T
S
N
K
R
S
P
A
A
Site 36
S197
H
G
T
S
N
K
R
S
P
A
A
S
Q
P
P
Site 37
S201
N
K
R
S
P
A
A
S
Q
P
P
V
S
R
V
Site 38
S206
A
A
S
Q
P
P
V
S
R
V
N
P
Q
E
E
Site 39
S214
R
V
N
P
Q
E
E
S
Y
Q
K
L
A
M
E
Site 40
Y215
V
N
P
Q
E
E
S
Y
Q
K
L
A
M
E
T
Site 41
T238
D
Q
L
E
T
I
Q
T
Y
R
S
V
S
E
M
Site 42
Y239
Q
L
E
T
I
Q
T
Y
R
S
V
S
E
M
A
Site 43
S241
E
T
I
Q
T
Y
R
S
V
S
E
M
A
S
N
Site 44
S243
I
Q
T
Y
R
S
V
S
E
M
A
S
N
K
F
Site 45
S247
R
S
V
S
E
M
A
S
N
K
F
K
R
M
L
Site 46
T259
R
M
L
N
R
E
L
T
H
L
S
E
M
S
R
Site 47
S262
N
R
E
L
T
H
L
S
E
M
S
R
S
G
N
Site 48
S267
H
L
S
E
M
S
R
S
G
N
Q
V
S
E
Y
Site 49
S272
S
R
S
G
N
Q
V
S
E
Y
I
S
N
T
F
Site 50
Y274
S
G
N
Q
V
S
E
Y
I
S
N
T
F
L
D
Site 51
S276
N
Q
V
S
E
Y
I
S
N
T
F
L
D
K
Q
Site 52
T278
V
S
E
Y
I
S
N
T
F
L
D
K
Q
N
D
Site 53
S290
Q
N
D
V
E
I
P
S
P
T
Q
K
D
R
E
Site 54
T292
D
V
E
I
P
S
P
T
Q
K
D
R
E
K
K
Site 55
S309
Q
Q
L
M
T
Q
I
S
G
V
K
K
L
M
H
Site 56
S318
V
K
K
L
M
H
S
S
S
L
N
N
T
S
I
Site 57
S319
K
K
L
M
H
S
S
S
L
N
N
T
S
I
S
Site 58
T323
H
S
S
S
L
N
N
T
S
I
S
R
F
G
V
Site 59
S324
S
S
S
L
N
N
T
S
I
S
R
F
G
V
N
Site 60
T332
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
Site 61
Y369
R
P
L
T
C
I
M
Y
A
I
F
Q
E
R
D
Site 62
T380
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
Site 63
Y391
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Site 64
Y399
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
Site 65
Y405
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
Site 66
T505
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
Site 67
S524
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
Site 68
Y549
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
Site 69
S566
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
Site 70
S571
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
Site 71
Y575
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
Site 72
T579
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
Site 73
S601
R
E
R
G
M
E
I
S
P
M
C
D
K
H
T
Site 74
T608
S
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
Site 75
S610
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
Site 76
S614
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
Site 77
T644
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Site 78
Y652
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
S
Site 79
S659
Y
Q
S
M
I
P
Q
S
P
S
P
P
L
D
E
Site 80
S661
S
M
I
P
Q
S
P
S
P
P
L
D
E
Q
N
Site 81
T683
E
K
F
Q
F
E
L
T
L
D
E
E
D
S
E
Site 82
S689
L
T
L
D
E
E
D
S
E
G
P
E
K
E
G
Site 83
S700
E
K
E
G
E
G
H
S
Y
F
S
S
T
K
T
Site 84
Y701
K
E
G
E
G
H
S
Y
F
S
S
T
K
T
L
Site 85
S703
G
E
G
H
S
Y
F
S
S
T
K
T
L
C
V
Site 86
S704
E
G
H
S
Y
F
S
S
T
K
T
L
C
V
I
Site 87
T707
S
Y
F
S
S
T
K
T
L
C
V
I
D
P
E
Site 88
S718
I
D
P
E
N
R
D
S
L
G
E
T
D
I
D
Site 89
T722
N
R
D
S
L
G
E
T
D
I
D
I
A
T
E
Site 90
T728
E
T
D
I
D
I
A
T
E
D
K
S
P
V
D
Site 91
S732
D
I
A
T
E
D
K
S
P
V
D
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation