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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCL1
Full Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Alias:
BCL2L3; Bcl-2-related protein EAT/mcl1; EAT/MCL-1; Mcl-1; Mcl1/EAT; Myeloid cell leukemia sequence 1; Myeloid cell leukemia sequence 1 (BCL2-related)
Type:
Apoptosis; Channel, misc.; Mitochondrial; Inhibitor protein
Mass (Da):
37337
Number AA:
350
UniProt ID:
Q07820
International Prot ID:
IPI00030356
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005741
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0015266
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0001709
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
G
A
G
S
G
G
A
T
R
P
G
G
R
L
L
Site 2
T38
P
G
G
R
L
L
A
T
E
K
E
A
S
A
R
Site 3
S43
L
A
T
E
K
E
A
S
A
R
R
E
I
G
G
Site 4
S60
A
G
A
V
I
G
G
S
A
G
A
S
P
P
S
Site 5
S64
I
G
G
S
A
G
A
S
P
P
S
T
L
T
P
Site 6
S67
S
A
G
A
S
P
P
S
T
L
T
P
D
S
R
Site 7
T68
A
G
A
S
P
P
S
T
L
T
P
D
S
R
R
Site 8
T70
A
S
P
P
S
T
L
T
P
D
S
R
R
V
A
Site 9
S73
P
S
T
L
T
P
D
S
R
R
V
A
R
P
P
Site 10
T92
E
V
P
D
V
T
A
T
P
A
R
L
L
F
F
Site 11
S121
P
A
A
D
A
I
M
S
P
E
E
E
L
D
G
Site 12
Y129
P
E
E
E
L
D
G
Y
E
P
E
P
L
G
K
Site 13
S150
L
L
E
L
V
G
E
S
G
N
N
T
S
T
D
Site 14
T154
V
G
E
S
G
N
N
T
S
T
D
G
S
L
P
Site 15
S155
G
E
S
G
N
N
T
S
T
D
G
S
L
P
S
Site 16
T156
E
S
G
N
N
T
S
T
D
G
S
L
P
S
T
Site 17
S159
N
N
T
S
T
D
G
S
L
P
S
T
P
P
P
Site 18
S162
S
T
D
G
S
L
P
S
T
P
P
P
A
E
E
Site 19
T163
T
D
G
S
L
P
S
T
P
P
P
A
E
E
E
Site 20
Y175
E
E
E
E
D
E
L
Y
R
Q
S
L
E
I
I
Site 21
S178
E
D
E
L
Y
R
Q
S
L
E
I
I
S
R
Y
Site 22
Y185
S
L
E
I
I
S
R
Y
L
R
E
Q
A
T
G
Site 23
S206
M
G
R
S
G
A
T
S
R
K
A
L
E
T
L
Site 24
T212
T
S
R
K
A
L
E
T
L
R
R
V
G
D
G
Site 25
S245
K
N
E
D
D
V
K
S
L
S
R
V
M
I
H
Site 26
S247
E
D
D
V
K
S
L
S
R
V
M
I
H
V
F
Site 27
T280
F
V
A
K
H
L
K
T
I
N
Q
E
S
C
I
Site 28
T301
I
T
D
V
L
V
R
T
K
R
D
W
L
V
K
Site 29
Y347
G
V
G
A
G
L
A
Y
L
I
R
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation