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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADCY1
Full Name:
Adenylate cyclase type 1
Alias:
AC1; Adenylate cyclase 1; Adenylate cyclase 1 (brain); Adenylate cyclase type I; Adenylate cyclase, type I; Adenylyl cyclase 1; ATP pyrophosphate-lyase; ATP pyrophosphate-lyase 1; Ca(2+)/calmodulin-activated adenylyl cyclase; Ca/calmodulin activated adenylyl cyclase; CYA1
Type:
EC 4.6.1.1; Lyase; Nucleotide Metabolism - purine; Adenylyl cyclase
Mass (Da):
123440
Number AA:
1119
UniProt ID:
Q08828
International Prot ID:
IPI00784385
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008294
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0007189
GO:0034199
GO:0006171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
G
A
E
R
A
A
G
T
S
R
R
R
G
L
R
Site 2
S28
A
E
R
A
A
G
T
S
R
R
R
G
L
R
A
Site 3
Y52
L
E
A
L
F
R
G
Y
T
L
R
L
E
Q
A
Site 4
T53
E
A
L
F
R
G
Y
T
L
R
L
E
Q
A
A
Site 5
S149
L
G
G
P
A
R
G
S
A
G
A
A
G
G
P
Site 6
T235
G
V
F
V
R
I
L
T
E
R
S
Q
R
K
A
Site 7
S238
V
R
I
L
T
E
R
S
Q
R
K
A
F
L
Q
Site 8
Y295
E
R
I
F
H
K
I
Y
I
Q
R
H
D
N
V
Site 9
Y416
L
G
L
R
K
W
Q
Y
D
V
W
S
N
D
V
Site 10
Y452
L
A
C
L
N
G
D
Y
E
V
E
P
G
Y
G
Site 11
Y458
D
Y
E
V
E
P
G
Y
G
H
E
R
N
S
F
Site 12
S464
G
Y
G
H
E
R
N
S
F
L
K
T
H
N
I
Site 13
T468
E
R
N
S
F
L
K
T
H
N
I
E
T
F
F
Site 14
S479
E
T
F
F
I
V
P
S
H
R
R
K
I
F
P
Site 15
T529
I
P
F
S
N
V
M
T
C
E
D
D
D
K
R
Site 16
T541
D
K
R
R
A
L
R
T
A
S
E
K
L
R
N
Site 17
S543
R
R
A
L
R
T
A
S
E
K
L
R
N
R
S
Site 18
S550
S
E
K
L
R
N
R
S
S
F
S
T
N
V
V
Site 19
S551
E
K
L
R
N
R
S
S
F
S
T
N
V
V
Y
Site 20
S553
L
R
N
R
S
S
F
S
T
N
V
V
Y
T
T
Site 21
T554
R
N
R
S
S
F
S
T
N
V
V
Y
T
T
P
Site 22
Y558
S
F
S
T
N
V
V
Y
T
T
P
G
T
R
V
Site 23
T559
F
S
T
N
V
V
Y
T
T
P
G
T
R
V
N
Site 24
T560
S
T
N
V
V
Y
T
T
P
G
T
R
V
N
R
Site 25
Y568
P
G
T
R
V
N
R
Y
I
S
R
L
L
E
A
Site 26
S570
T
R
V
N
R
Y
I
S
R
L
L
E
A
R
Q
Site 27
T578
R
L
L
E
A
R
Q
T
E
L
E
M
A
D
L
Site 28
Y592
L
N
F
F
T
L
K
Y
K
H
V
E
R
E
Q
Site 29
Y608
Y
H
Q
L
Q
D
E
Y
F
T
S
A
V
V
L
Site 30
S700
G
C
L
P
W
A
W
S
S
K
P
N
S
S
L
Site 31
S701
C
L
P
W
A
W
S
S
K
P
N
S
S
L
V
Site 32
S705
A
W
S
S
K
P
N
S
S
L
V
V
L
S
S
Site 33
S706
W
S
S
K
P
N
S
S
L
V
V
L
S
S
G
Site 34
T717
L
S
S
G
G
Q
R
T
A
L
P
T
L
P
C
Site 35
T721
G
Q
R
T
A
L
P
T
L
P
C
E
S
T
H
Site 36
S781
R
T
G
G
G
A
V
S
G
R
S
Y
E
P
I
Site 37
Y813
D
I
R
L
R
L
D
Y
L
W
A
A
Q
A
E
Site 38
Y860
N
P
R
N
M
D
L
Y
Y
Q
S
Y
S
Q
V
Site 39
Y861
P
R
N
M
D
L
Y
Y
Q
S
Y
S
Q
V
G
Site 40
Y881
I
P
N
F
N
D
F
Y
I
E
L
D
G
N
N
Site 41
Y913
E
L
M
E
K
D
F
Y
K
D
I
E
K
I
K
Site 42
T921
K
D
I
E
K
I
K
T
I
G
S
T
Y
M
A
Site 43
Y926
I
K
T
I
G
S
T
Y
M
A
A
V
G
L
A
Site 44
T935
A
A
V
G
L
A
P
T
S
G
T
K
A
K
K
Site 45
S936
A
V
G
L
A
P
T
S
G
T
K
A
K
K
S
Site 46
S943
S
G
T
K
A
K
K
S
I
S
S
H
L
S
T
Site 47
S945
T
K
A
K
K
S
I
S
S
H
L
S
T
L
A
Site 48
S946
K
A
K
K
S
I
S
S
H
L
S
T
L
A
D
Site 49
Y967
D
V
L
D
E
I
N
Y
Q
S
Y
N
D
F
V
Site 50
Y996
I
G
A
R
R
P
Q
Y
D
I
W
G
N
T
V
Site 51
S1007
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
Site 52
S1011
N
V
A
S
R
M
D
S
T
G
V
Q
G
R
I
Site 53
T1012
V
A
S
R
M
D
S
T
G
V
Q
G
R
I
Q
Site 54
Y1033
R
L
L
R
R
C
P
Y
H
F
V
C
R
G
K
Site 55
T1051
K
G
K
G
E
M
L
T
Y
F
L
E
G
R
T
Site 56
Y1052
G
K
G
E
M
L
T
Y
F
L
E
G
R
T
D
Site 57
S1063
G
R
T
D
G
N
G
S
Q
I
R
S
L
G
L
Site 58
S1067
G
N
G
S
Q
I
R
S
L
G
L
D
R
K
M
Site 59
S1105
R
A
G
L
P
P
H
S
P
G
Q
Y
L
P
S
Site 60
Y1109
P
P
H
S
P
G
Q
Y
L
P
S
A
A
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation