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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAP4K2
Full Name:
Mitogen-activated protein kinase kinase kinase kinase 2
Alias:
B lymphocyte serine/threonine-protein kinase; BL44; EC 2.7.11.1; GCK; Germinal center kinase; Kinase GCK; M4K2; M4K2_HUMAN; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; MEKKK2; Rab8 interacting protein; RAB8IP
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
STE
group; STE20 family; KHS subfamily
Mass (Da):
91556
Number AA:
820
UniProt ID:
Q12851
International Prot ID:
IPI00149094
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0006955
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Germinal centre protein-serine kinase; Mitogen-activated protein kinase kinase kinase kinase 2 S170 phosphosite-specific antibody AB-PK646#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK646#Germinal centre protein-serine kinase / Mitogen-activated protein kinase kinase kinase kinase 2 (K167-G173, human) pS170 phosphopeptide - Powder PE-04AMQ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMQ99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
L
L
R
D
V
S
L
Q
D
P
R
D
R
Site 2
T26
L
Q
R
V
G
A
G
T
Y
G
D
V
Y
K
A
Site 3
Y27
Q
R
V
G
A
G
T
Y
G
D
V
Y
K
A
R
Site 4
Y31
A
G
T
Y
G
D
V
Y
K
A
R
D
T
V
T
Site 5
T36
D
V
Y
K
A
R
D
T
V
T
S
E
L
A
A
Site 6
S39
K
A
R
D
T
V
T
S
E
L
A
A
V
K
I
Site 7
S56
L
D
P
G
D
D
I
S
S
L
Q
Q
E
I
T
Site 8
S57
D
P
G
D
D
I
S
S
L
Q
Q
E
I
T
I
Site 9
T63
S
S
L
Q
Q
E
I
T
I
L
R
E
C
R
H
Site 10
Y76
R
H
P
N
V
V
A
Y
I
G
S
Y
L
R
N
Site 11
S79
N
V
V
A
Y
I
G
S
Y
L
R
N
D
R
L
Site 12
Y102
G
G
S
L
Q
E
I
Y
H
A
T
G
P
L
E
Site 13
Y115
L
E
E
R
Q
I
A
Y
V
C
R
E
A
L
K
Site 14
S129
K
G
L
H
H
L
H
S
Q
G
K
I
H
R
D
Site 15
T162
F
G
V
S
G
E
L
T
A
S
V
A
K
R
R
Site 16
S164
V
S
G
E
L
T
A
S
V
A
K
R
R
S
F
Site 17
S170
A
S
V
A
K
R
R
S
F
I
G
T
P
Y
W
Germinal centre protein-serine kinase; Mitogen-activated protein kinase kinase kinase kinase 2 S170 phosphosite-specific antibody AB-PK646#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK646#Germinal centre protein-serine kinase / Mitogen-activated protein kinase kinase kinase kinase 2 (K167-G173, human) pS170 phosphopeptide - Powder PE-04AMQ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMQ99
Site 18
T174
K
R
R
S
F
I
G
T
P
Y
W
M
A
P
E
Site 19
S227
M
R
A
L
M
L
M
S
K
S
S
F
Q
P
P
Site 20
S229
A
L
M
L
M
S
K
S
S
F
Q
P
P
K
L
Site 21
S230
L
M
L
M
S
K
S
S
F
Q
P
P
K
L
R
Site 22
T255
H
F
L
K
L
A
L
T
K
N
P
K
K
R
P
Site 23
T263
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
Site 24
T273
K
L
L
Q
H
P
F
T
T
Q
Q
L
P
R
A
Site 25
S290
T
Q
L
L
D
K
A
S
D
P
H
L
G
T
P
Site 26
T296
A
S
D
P
H
L
G
T
P
S
P
E
D
C
E
Site 27
S298
D
P
H
L
G
T
P
S
P
E
D
C
E
L
E
Site 28
T306
P
E
D
C
E
L
E
T
Y
D
M
F
P
D
T
Site 29
Y307
E
D
C
E
L
E
T
Y
D
M
F
P
D
T
I
Site 30
T326
Q
H
G
P
A
E
R
T
P
S
E
I
Q
F
H
Site 31
S328
G
P
A
E
R
T
P
S
E
I
Q
F
H
Q
V
Site 32
T345
G
A
P
R
R
K
E
T
D
P
L
N
E
P
W
Site 33
T357
E
P
W
E
E
E
W
T
L
L
G
K
E
E
L
Site 34
S367
G
K
E
E
L
S
G
S
L
L
Q
S
V
Q
E
Site 35
S371
L
S
G
S
L
L
Q
S
V
Q
E
A
L
E
E
Site 36
S380
Q
E
A
L
E
E
R
S
L
T
I
R
S
A
S
Site 37
T382
A
L
E
E
R
S
L
T
I
R
S
A
S
E
F
Site 38
S385
E
R
S
L
T
I
R
S
A
S
E
F
Q
E
L
Site 39
S387
S
L
T
I
R
S
A
S
E
F
Q
E
L
D
S
Site 40
S394
S
E
F
Q
E
L
D
S
P
D
D
T
M
G
T
Site 41
T398
E
L
D
S
P
D
D
T
M
G
T
I
K
R
A
Site 42
T401
S
P
D
D
T
M
G
T
I
K
R
A
P
F
L
Site 43
T413
P
F
L
G
P
L
P
T
D
P
P
A
E
E
P
Site 44
S422
P
P
A
E
E
P
L
S
S
P
P
G
T
L
P
Site 45
S423
P
A
E
E
P
L
S
S
P
P
G
T
L
P
P
Site 46
T427
P
L
S
S
P
P
G
T
L
P
P
P
P
S
G
Site 47
S433
G
T
L
P
P
P
P
S
G
P
N
S
S
P
L
Site 48
S437
P
P
P
S
G
P
N
S
S
P
L
L
P
T
A
Site 49
S438
P
P
S
G
P
N
S
S
P
L
L
P
T
A
W
Site 50
S458
R
E
D
P
E
R
S
S
C
H
G
L
P
P
T
Site 51
T465
S
C
H
G
L
P
P
T
P
K
V
H
M
G
A
Site 52
T511
G
A
E
E
G
I
Y
T
L
N
L
H
E
L
H
Site 53
T521
L
H
E
L
H
E
D
T
L
E
K
L
I
S
H
Site 54
S542
C
V
N
N
V
L
L
S
L
S
G
K
S
T
H
Site 55
S544
N
N
V
L
L
S
L
S
G
K
S
T
H
I
W
Site 56
S547
L
L
S
L
S
G
K
S
T
H
I
W
A
H
D
Site 57
T548
L
S
L
S
G
K
S
T
H
I
W
A
H
D
L
Site 58
S571
L
Q
Q
Q
V
P
L
S
I
P
T
N
R
L
T
Site 59
T578
S
I
P
T
N
R
L
T
Q
R
I
I
P
R
R
Site 60
S589
I
P
R
R
F
A
L
S
T
K
I
P
D
T
K
Site 61
T590
P
R
R
F
A
L
S
T
K
I
P
D
T
K
G
Site 62
T595
L
S
T
K
I
P
D
T
K
G
C
L
Q
C
R
Site 63
S646
N
F
S
S
P
L
P
S
P
A
G
M
L
E
P
Site 64
S703
P
P
E
G
I
P
G
S
A
Q
Q
V
I
Q
V
Site 65
S718
D
R
D
T
I
L
V
S
F
E
R
C
V
R
I
Site 66
T735
M
Q
G
E
P
T
A
T
L
A
P
E
L
T
F
Site 67
S761
D
S
V
L
A
F
W
S
H
G
M
Q
G
R
S
Site 68
S798
H
R
D
I
I
L
E
S
I
P
T
D
N
P
E
Site 69
T801
I
I
L
E
S
I
P
T
D
N
P
E
A
H
S
Site 70
Y811
P
E
A
H
S
N
L
Y
I
L
T
G
H
Q
S
Site 71
T814
H
S
N
L
Y
I
L
T
G
H
Q
S
T
Y
_
Site 72
T819
I
L
T
G
H
Q
S
T
Y
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation