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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRAF2
Full Name:
TNF receptor-associated factor 2
Alias:
TNF receptor associated factor 2; TRAP3; tumor necrosis factor type 2 receptor associated protein 3
Type:
Adapter protein and signal transducer
Mass (Da):
55859
Number AA:
501
UniProt ID:
Q12933
International Prot ID:
IPI00030278
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007250
GO:0008633
GO:0050870
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
A
A
S
V
T
P
P
G
S
L
Site 2
T7
_
M
A
A
A
S
V
T
P
P
G
S
L
E
L
Site 3
S11
A
S
V
T
P
P
G
S
L
E
L
L
Q
P
G
Site 4
S20
E
L
L
Q
P
G
F
S
K
T
L
L
G
T
K
Site 5
T22
L
Q
P
G
F
S
K
T
L
L
G
T
K
L
E
Site 6
T26
F
S
K
T
L
L
G
T
K
L
E
A
K
Y
L
Site 7
Y32
G
T
K
L
E
A
K
Y
L
C
S
A
C
R
N
Site 8
S55
Q
C
G
H
R
Y
C
S
F
C
L
A
S
I
L
Site 9
S83
G
I
Y
E
E
G
I
S
I
L
E
S
S
S
A
Site 10
S87
E
G
I
S
I
L
E
S
S
S
A
F
P
D
N
Site 11
S102
A
A
R
R
E
V
E
S
L
P
A
V
C
P
S
Site 12
S109
S
L
P
A
V
C
P
S
D
G
C
T
W
K
G
Site 13
T113
V
C
P
S
D
G
C
T
W
K
G
T
L
K
E
Site 14
T117
D
G
C
T
W
K
G
T
L
K
E
Y
E
S
C
Site 15
Y121
W
K
G
T
L
K
E
Y
E
S
C
H
E
G
R
Site 16
S162
E
C
P
E
R
S
L
S
C
R
H
C
R
A
P
Site 17
T188
V
C
P
K
F
P
L
T
C
D
G
C
G
K
K
Site 18
T226
H
A
I
G
C
L
E
T
V
E
G
E
K
Q
Q
Site 19
S262
K
P
L
L
G
D
Q
S
H
A
G
S
E
L
L
Site 20
S266
G
D
Q
S
H
A
G
S
E
L
L
Q
R
C
E
Site 21
S274
E
L
L
Q
R
C
E
S
L
E
K
K
T
A
T
Site 22
S319
D
K
I
E
A
L
S
S
K
V
Q
Q
L
E
R
Site 23
Y350
L
E
M
E
A
S
T
Y
D
G
V
F
I
W
K
Site 24
S378
G
R
I
P
A
I
F
S
P
A
F
Y
T
S
R
Site 25
Y382
A
I
F
S
P
A
F
Y
T
S
R
Y
G
Y
K
Site 26
Y386
P
A
F
Y
T
S
R
Y
G
Y
K
M
C
L
R
Site 27
Y388
F
Y
T
S
R
Y
G
Y
K
M
C
L
R
I
Y
Site 28
Y395
Y
K
M
C
L
R
I
Y
L
N
G
D
G
T
G
Site 29
T401
I
Y
L
N
G
D
G
T
G
R
G
T
H
L
S
Site 30
T431
W
P
F
N
Q
K
V
T
L
M
L
L
D
Q
N
Site 31
T452
D
A
F
R
P
D
V
T
S
S
S
F
Q
R
P
Site 32
S453
A
F
R
P
D
V
T
S
S
S
F
Q
R
P
V
Site 33
S454
F
R
P
D
V
T
S
S
S
F
Q
R
P
V
N
Site 34
S455
R
P
D
V
T
S
S
S
F
Q
R
P
V
N
D
Site 35
S476
C
P
L
F
C
P
V
S
K
M
E
A
K
N
S
Site 36
S483
S
K
M
E
A
K
N
S
Y
V
R
D
D
A
I
Site 37
Y484
K
M
E
A
K
N
S
Y
V
R
D
D
A
I
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation