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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP1R8
Full Name:
Nuclear inhibitor of protein phosphatase 1
Alias:
Activator of RNA decay; ARD1; ARD-1; EC 3.1.4.-; NIPP1; NIPP-1; Nuclear inhibitor of protein phosphatase-1; PP1R8; PPR8; Protein phosphatase 1, regulatory inhibitor subunit 8
Type:
Regulatory protein, protein phosphatase inhibitior
Mass (Da):
38479
Number AA:
351
UniProt ID:
Q12972
International Prot ID:
IsoformAlpha - IPI00030383
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016607
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003723
GO:0004519
PhosphoSite+
KinaseNET
Biological Process:
GO:0006401
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
L
P
L
F
D
C
P
T
W
A
G
K
P
P
P
Site 2
Y48
L
I
I
D
E
K
K
Y
Y
L
F
G
R
N
P
Site 3
Y49
I
I
D
E
K
K
Y
Y
L
F
G
R
N
P
D
Site 4
T94
D
L
N
S
T
H
G
T
F
L
G
H
I
R
L
Site 5
S113
P
Q
Q
I
P
I
D
S
T
V
S
F
G
A
S
Site 6
T114
Q
Q
I
P
I
D
S
T
V
S
F
G
A
S
T
Site 7
S120
S
T
V
S
F
G
A
S
T
R
A
Y
T
L
R
Site 8
T121
T
V
S
F
G
A
S
T
R
A
Y
T
L
R
E
Site 9
Y124
F
G
A
S
T
R
A
Y
T
L
R
E
K
P
Q
Site 10
T125
G
A
S
T
R
A
Y
T
L
R
E
K
P
Q
T
Site 11
T132
T
L
R
E
K
P
Q
T
L
P
S
A
V
K
G
Site 12
T161
L
G
L
P
E
E
E
T
E
L
D
N
L
T
E
Site 13
T167
E
T
E
L
D
N
L
T
E
F
N
T
A
H
N
Site 14
S178
T
A
H
N
K
R
I
S
T
L
T
I
E
E
G
Site 15
T179
A
H
N
K
R
I
S
T
L
T
I
E
E
G
N
Site 16
T181
N
K
R
I
S
T
L
T
I
E
E
G
N
L
D
Site 17
S199
P
K
R
K
R
K
N
S
R
V
T
F
S
E
D
Site 18
T202
K
R
K
N
S
R
V
T
F
S
E
D
D
E
I
Site 19
S204
K
N
S
R
V
T
F
S
E
D
D
E
I
I
N
Site 20
S218
N
P
E
D
V
D
P
S
V
G
R
F
R
N
M
Site 21
T228
R
F
R
N
M
V
Q
T
A
V
V
P
V
K
K
Site 22
S243
K
R
V
E
G
P
G
S
L
G
L
E
E
S
G
Site 23
S249
G
S
L
G
L
E
E
S
G
S
R
R
M
Q
N
Site 24
S251
L
G
L
E
E
S
G
S
R
R
M
Q
N
F
A
Site 25
Y264
F
A
F
S
G
G
L
Y
G
G
L
P
P
T
H
Site 26
T270
L
Y
G
G
L
P
P
T
H
S
E
A
G
S
Q
Site 27
S272
G
G
L
P
P
T
H
S
E
A
G
S
Q
P
H
Site 28
S276
P
T
H
S
E
A
G
S
Q
P
H
G
I
H
G
Site 29
Y335
N
E
P
K
K
K
K
Y
A
K
E
A
W
P
G
Site 30
T346
A
W
P
G
K
K
P
T
P
S
L
L
I
_
_
Site 31
S348
P
G
K
K
P
T
P
S
L
L
I
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation