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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRIK2
Full Name:
Glutamate receptor, ionotropic kainate 2
Alias:
EAA4; Excitatory amino acid receptor 4; GLK2; GLUR6; GluR-6; Glutamate receptor 6; Glutamate receptor, ionotropic kainate 2; Glutamate receptor, ionotropic, kainate 2
Type:
Channel, calcium; Channel, ligand-gated
Mass (Da):
102583
Number AA:
908
UniProt ID:
Q13002
International Prot ID:
IPI00011396
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0005234
GO:0015277
PhosphoSite+
KinaseNET
Biological Process:
GO:0007215
GO:0031557
GO:0006811
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
I
G
Y
S
Q
G
T
T
H
V
L
R
F
G
G
Site 2
Y44
R
F
G
G
I
F
E
Y
V
E
S
G
P
M
G
Site 3
S47
G
I
F
E
Y
V
E
S
G
P
M
G
A
E
E
Site 4
T63
A
F
R
F
A
V
N
T
I
N
R
N
R
T
L
Site 5
T69
N
T
I
N
R
N
R
T
L
L
P
N
T
T
L
Site 6
T80
N
T
T
L
T
Y
D
T
Q
K
I
N
L
Y
D
Site 7
Y86
D
T
Q
K
I
N
L
Y
D
S
F
E
A
S
K
Site 8
S88
Q
K
I
N
L
Y
D
S
F
E
A
S
K
K
A
Site 9
S92
L
Y
D
S
F
E
A
S
K
K
A
C
D
Q
L
Site 10
S112
A
I
F
G
P
S
H
S
S
S
A
N
A
V
Q
Site 11
S114
F
G
P
S
H
S
S
S
A
N
A
V
Q
S
I
Site 12
S144
Q
V
S
D
N
K
D
S
F
Y
V
S
L
Y
P
Site 13
Y146
S
D
N
K
D
S
F
Y
V
S
L
Y
P
D
F
Site 14
S148
N
K
D
S
F
Y
V
S
L
Y
P
D
F
S
S
Site 15
Y150
D
S
F
Y
V
S
L
Y
P
D
F
S
S
L
S
Site 16
S155
S
L
Y
P
D
F
S
S
L
S
R
A
I
L
D
Site 17
T171
V
Q
F
F
K
W
K
T
V
T
V
V
Y
D
D
Site 18
T173
F
F
K
W
K
T
V
T
V
V
Y
D
D
S
T
Site 19
T180
T
V
V
Y
D
D
S
T
G
L
I
R
L
Q
E
Site 20
S193
Q
E
L
I
K
A
P
S
R
Y
N
L
R
L
K
Site 21
Y269
F
A
L
D
V
E
P
Y
R
Y
S
G
V
N
M
Site 22
Y271
L
D
V
E
P
Y
R
Y
S
G
V
N
M
T
G
Site 23
S272
D
V
E
P
Y
R
Y
S
G
V
N
M
T
G
F
Site 24
T287
R
I
L
N
T
E
N
T
Q
V
S
S
I
I
E
Site 25
S297
S
S
I
I
E
K
W
S
M
E
R
L
Q
A
P
Site 26
S309
Q
A
P
P
K
P
D
S
G
L
L
D
G
F
M
Site 27
T341
V
Q
Q
F
P
Q
M
T
V
S
S
L
Q
C
N
Site 28
S361
R
F
G
T
R
F
M
S
L
I
K
E
A
H
W
Site 29
T372
E
A
H
W
E
G
L
T
G
R
I
T
F
N
K
Site 30
T376
E
G
L
T
G
R
I
T
F
N
K
T
N
G
L
Site 31
S393
D
F
D
L
D
V
I
S
L
K
E
E
G
L
E
Site 32
T404
E
G
L
E
K
I
G
T
W
D
P
A
S
G
L
Site 33
S409
I
G
T
W
D
P
A
S
G
L
N
M
T
E
S
Site 34
S416
S
G
L
N
M
T
E
S
Q
K
G
K
P
A
N
Site 35
T425
K
G
K
P
A
N
I
T
D
S
L
S
N
R
S
Site 36
S427
K
P
A
N
I
T
D
S
L
S
N
R
S
L
I
Site 37
T436
S
N
R
S
L
I
V
T
T
I
L
E
E
P
Y
Site 38
Y443
T
T
I
L
E
E
P
Y
V
L
F
K
K
S
D
Site 39
S449
P
Y
V
L
F
K
K
S
D
K
P
L
Y
G
N
Site 40
Y454
K
K
S
D
K
P
L
Y
G
N
D
R
F
E
G
Site 41
Y462
G
N
D
R
F
E
G
Y
C
I
D
L
L
R
E
Site 42
Y488
R
L
V
E
D
G
K
Y
G
A
Q
D
D
A
N
Site 43
S530
R
E
K
V
I
D
F
S
K
P
F
M
T
L
G
Site 44
Y542
T
L
G
I
S
I
L
Y
R
K
P
N
G
T
N
Site 45
T548
L
Y
R
K
P
N
G
T
N
P
G
V
F
S
F
Site 46
Y587
V
I
A
R
F
S
P
Y
E
W
Y
N
P
H
P
Site 47
S666
L
T
V
E
R
M
E
S
P
I
D
S
A
D
D
Site 48
S670
R
M
E
S
P
I
D
S
A
D
D
L
A
K
Q
Site 49
Y682
A
K
Q
T
K
I
E
Y
G
A
V
E
D
G
A
Site 50
T690
G
A
V
E
D
G
A
T
M
T
F
F
K
K
S
Site 51
T692
V
E
D
G
A
T
M
T
F
F
K
K
S
K
I
Site 52
S697
T
M
T
F
F
K
K
S
K
I
S
T
Y
D
K
Site 53
T701
F
K
K
S
K
I
S
T
Y
D
K
M
W
A
F
Site 54
Y702
K
K
S
K
I
S
T
Y
D
K
M
W
A
F
M
Site 55
S710
D
K
M
W
A
F
M
S
S
R
R
Q
S
V
L
Site 56
S711
K
M
W
A
F
M
S
S
R
R
Q
S
V
L
V
Site 57
S715
F
M
S
S
R
R
Q
S
V
L
V
K
S
N
E
Site 58
S720
R
Q
S
V
L
V
K
S
N
E
E
G
I
Q
R
Site 59
Y733
Q
R
V
L
T
S
D
Y
A
F
L
M
E
S
T
Site 60
T746
S
T
T
I
E
F
V
T
Q
R
N
C
N
L
T
Site 61
T753
T
Q
R
N
C
N
L
T
Q
I
G
G
L
I
D
Site 62
S761
Q
I
G
G
L
I
D
S
K
G
Y
G
V
G
T
Site 63
T768
S
K
G
Y
G
V
G
T
P
M
G
S
P
Y
R
Site 64
S772
G
V
G
T
P
M
G
S
P
Y
R
D
K
I
T
Site 65
T779
S
P
Y
R
D
K
I
T
I
A
I
L
Q
L
Q
Site 66
S809
N
G
C
P
E
E
E
S
K
E
A
S
A
L
G
Site 67
S813
E
E
E
S
K
E
A
S
A
L
G
V
Q
N
I
Site 68
Y844
V
A
V
G
E
F
L
Y
K
S
K
K
N
A
Q
Site 69
S846
V
G
E
F
L
Y
K
S
K
K
N
A
Q
L
E
Site 70
S856
N
A
Q
L
E
K
R
S
F
C
S
A
M
V
E
Site 71
S868
M
V
E
E
L
R
M
S
L
K
C
Q
R
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation