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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LCP2
Full Name:
Lymphocyte cytosolic protein 2
Alias:
76 kDa tyrosine phosphoprotein; SH2 domain containing leukocyte protein of 76kDa; SH2 domain-containing leucocyte protein of 76 kDa; SH2 domain-containing leukocyte protein of 76kD; SLP76; SLP-76; SLP-76 tyrosine phosphoprotein
Type:
Adapter/scaffold protein
Mass (Da):
60188
Number AA:
533
UniProt ID:
Q13094
International Prot ID:
IPI00297169
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0007169
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
R
N
V
P
F
R
S
E
V
L
G
W
D
P
Site 2
S19
V
L
G
W
D
P
D
S
L
A
D
Y
F
K
K
Site 3
Y23
D
P
D
S
L
A
D
Y
F
K
K
L
N
Y
K
Site 4
T50
G
A
R
F
L
N
L
T
E
N
D
I
Q
K
F
Site 5
S66
K
L
R
V
P
I
L
S
K
L
S
Q
E
I
N
Site 6
S69
V
P
I
L
S
K
L
S
Q
E
I
N
K
N
E
Site 7
S80
N
K
N
E
E
R
R
S
I
F
T
R
K
P
Q
Site 8
T83
E
E
R
R
S
I
F
T
R
K
P
Q
V
P
R
Site 9
T95
V
P
R
F
P
E
E
T
E
S
H
E
E
D
N
Site 10
S97
R
F
P
E
E
T
E
S
H
E
E
D
N
G
G
Site 11
S106
E
E
D
N
G
G
W
S
S
F
E
E
D
D
Y
Site 12
S107
E
D
N
G
G
W
S
S
F
E
E
D
D
Y
E
Site 13
Y113
S
S
F
E
E
D
D
Y
E
S
P
N
D
D
Q
Site 14
S115
F
E
E
D
D
Y
E
S
P
N
D
D
Q
D
G
Site 15
Y128
D
G
E
D
D
G
D
Y
E
S
P
N
E
E
E
Site 16
S130
E
D
D
G
D
Y
E
S
P
N
E
E
E
E
A
Site 17
Y145
P
V
E
D
D
A
D
Y
E
P
P
P
S
N
D
Site 18
S150
A
D
Y
E
P
P
P
S
N
D
E
E
A
L
Q
Site 19
S169
P
A
K
P
F
P
N
S
N
S
M
Y
I
D
R
Site 20
S171
K
P
F
P
N
S
N
S
M
Y
I
D
R
P
P
Site 21
Y173
F
P
N
S
N
S
M
Y
I
D
R
P
P
S
G
Site 22
S179
M
Y
I
D
R
P
P
S
G
K
T
P
Q
Q
P
Site 23
T182
D
R
P
P
S
G
K
T
P
Q
Q
P
P
V
P
Site 24
S207
P
P
A
G
R
N
H
S
P
L
P
P
P
Q
T
Site 25
T214
S
P
L
P
P
P
Q
T
N
H
E
E
P
S
R
Site 26
S222
N
H
E
E
P
S
R
S
R
N
H
K
T
A
K
Site 27
T227
S
R
S
R
N
H
K
T
A
K
L
P
A
P
S
Site 28
S234
T
A
K
L
P
A
P
S
I
D
R
S
T
K
P
Site 29
S238
P
A
P
S
I
D
R
S
T
K
P
P
L
D
R
Site 30
T239
A
P
S
I
D
R
S
T
K
P
P
L
D
R
S
Site 31
S246
T
K
P
P
L
D
R
S
L
A
P
F
D
R
E
Site 32
T256
P
F
D
R
E
P
F
T
L
G
K
K
P
P
F
Site 33
S264
L
G
K
K
P
P
F
S
D
K
P
S
I
P
A
Site 34
S268
P
P
F
S
D
K
P
S
I
P
A
G
R
S
L
Site 35
S274
P
S
I
P
A
G
R
S
L
G
E
H
L
P
K
Site 36
T290
Q
K
P
P
L
P
P
T
T
E
R
H
E
R
S
Site 37
T291
K
P
P
L
P
P
T
T
E
R
H
E
R
S
S
Site 38
S298
T
E
R
H
E
R
S
S
P
L
P
G
K
K
P
Site 39
S338
Q
P
A
L
L
P
M
S
S
N
T
F
P
S
R
Site 40
S339
P
A
L
L
P
M
S
S
N
T
F
P
S
R
S
Site 41
T341
L
L
P
M
S
S
N
T
F
P
S
R
S
T
K
Site 42
S344
M
S
S
N
T
F
P
S
R
S
T
K
P
S
P
Site 43
S346
S
N
T
F
P
S
R
S
T
K
P
S
P
M
N
Site 44
T347
N
T
F
P
S
R
S
T
K
P
S
P
M
N
P
Site 45
S350
P
S
R
S
T
K
P
S
P
M
N
P
L
P
S
Site 46
S357
S
P
M
N
P
L
P
S
S
H
M
P
G
A
F
Site 47
S358
P
M
N
P
L
P
S
S
H
M
P
G
A
F
S
Site 48
S365
S
H
M
P
G
A
F
S
E
S
N
S
S
F
P
Site 49
S367
M
P
G
A
F
S
E
S
N
S
S
F
P
Q
S
Site 50
S369
G
A
F
S
E
S
N
S
S
F
P
Q
S
A
S
Site 51
S370
A
F
S
E
S
N
S
S
F
P
Q
S
A
S
L
Site 52
S374
S
N
S
S
F
P
Q
S
A
S
L
P
P
Y
F
Site 53
S376
S
S
F
P
Q
S
A
S
L
P
P
Y
F
S
Q
Site 54
Y380
Q
S
A
S
L
P
P
Y
F
S
Q
G
P
S
N
Site 55
S382
A
S
L
P
P
Y
F
S
Q
G
P
S
N
R
P
Site 56
S386
P
Y
F
S
Q
G
P
S
N
R
P
P
I
R
A
Site 57
S410
P
N
K
P
R
P
P
S
P
A
E
E
E
N
S
Site 58
S417
S
P
A
E
E
E
N
S
L
N
E
E
W
Y
V
Site 59
Y423
N
S
L
N
E
E
W
Y
V
S
Y
I
T
R
P
Site 60
S425
L
N
E
E
W
Y
V
S
Y
I
T
R
P
E
A
Site 61
T428
E
W
Y
V
S
Y
I
T
R
P
E
A
E
A
A
Site 62
T444
R
K
I
N
Q
D
G
T
F
L
V
R
D
S
S
Site 63
S450
G
T
F
L
V
R
D
S
S
K
K
T
T
T
N
Site 64
S451
T
F
L
V
R
D
S
S
K
K
T
T
T
N
P
Site 65
T454
V
R
D
S
S
K
K
T
T
T
N
P
Y
V
L
Site 66
T455
R
D
S
S
K
K
T
T
T
N
P
Y
V
L
M
Site 67
T456
D
S
S
K
K
T
T
T
N
P
Y
V
L
M
V
Site 68
Y459
K
K
T
T
T
N
P
Y
V
L
M
V
L
Y
K
Site 69
Y465
P
Y
V
L
M
V
L
Y
K
D
K
V
Y
N
I
Site 70
Y470
V
L
Y
K
D
K
V
Y
N
I
Q
I
R
Y
Q
Site 71
Y476
V
Y
N
I
Q
I
R
Y
Q
K
E
S
Q
V
Y
Site 72
S480
Q
I
R
Y
Q
K
E
S
Q
V
Y
L
L
G
T
Site 73
Y483
Y
Q
K
E
S
Q
V
Y
L
L
G
T
G
L
R
Site 74
S497
R
G
K
E
D
F
L
S
V
S
D
I
I
D
Y
Site 75
S499
K
E
D
F
L
S
V
S
D
I
I
D
Y
F
R
Site 76
S520
I
D
G
K
N
R
G
S
R
Y
Q
C
T
L
T
Site 77
Y522
G
K
N
R
G
S
R
Y
Q
C
T
L
T
H
A
Site 78
T525
R
G
S
R
Y
Q
C
T
L
T
H
A
A
G
Y
Site 79
T527
S
R
Y
Q
C
T
L
T
H
A
A
G
Y
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation