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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKG2
Full Name:
cGMP-dependent protein kinase 2
Alias:
CGK 2; CGKII; EC 2.7.11.12; KGP2; Kinase cGMP-dependent protein kinase 2PKG2; PRKG2; PRKGR2; Protein kinase, cGMP-dependent, type II; Type II cGMP-dependent protein kinase
Type:
EC 2.7.11.12; Protein kinase, Ser/Thr (non-receptor);
AGC
group; PKG family
Mass (Da):
87432
Number AA:
762
UniProt ID:
Q13237
International Prot ID:
IPI00012322
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030553
GO:0004692
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
cGMP-dependent protein kinase 2 pan-specific antibody AB-NK290-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK290-1#cGMP-dependent protein kinase 2 (L397-R415, human) peptide - Powder PE-01BEW90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEW90#cGMP-dependent protein kinase 2 (S422-K440, human) peptide - Powder PE-01BEX70#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEX70#PKG2Subtide - PKG2 (PRKG2) protein kinase substrate peptide - Powder PE-01BIX99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIX99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
G
S
V
K
P
K
H
S
K
H
P
D
G
H
S
Site 2
S18
S
K
H
P
D
G
H
S
G
N
L
T
T
D
A
Site 3
T22
D
G
H
S
G
N
L
T
T
D
A
L
R
N
K
Site 4
Y49
A
E
I
Q
E
R
E
Y
H
L
K
E
L
R
E
Site 5
S59
K
E
L
R
E
Q
L
S
K
Q
T
V
A
I
A
Site 6
S92
V
V
H
M
Q
G
G
S
P
L
Q
A
S
P
D
Site 7
S97
G
G
S
P
L
Q
A
S
P
D
K
V
P
L
E
Site 8
T109
P
L
E
V
H
R
K
T
S
G
L
V
S
L
H
Site 9
S110
L
E
V
H
R
K
T
S
G
L
V
S
L
H
S
Site 10
S114
R
K
T
S
G
L
V
S
L
H
S
R
R
G
A
Site 11
S117
S
G
L
V
S
L
H
S
R
R
G
A
K
A
G
Site 12
S126
R
G
A
K
A
G
V
S
A
E
P
T
T
R
T
Site 13
T130
A
G
V
S
A
E
P
T
T
R
T
Y
D
L
N
Site 14
T131
G
V
S
A
E
P
T
T
R
T
Y
D
L
N
K
Site 15
Y134
A
E
P
T
T
R
T
Y
D
L
N
K
P
P
E
Site 16
S143
L
N
K
P
P
E
F
S
F
E
K
A
R
V
R
Site 17
S153
K
A
R
V
R
K
D
S
S
E
K
K
L
I
T
Site 18
S154
A
R
V
R
K
D
S
S
E
K
K
L
I
T
D
Site 19
Y185
K
D
M
V
E
C
M
Y
G
R
N
Y
Q
Q
G
Site 20
Y189
E
C
M
Y
G
R
N
Y
Q
Q
G
S
Y
I
I
Site 21
S193
G
R
N
Y
Q
Q
G
S
Y
I
I
K
Q
G
E
Site 22
S223
F
Q
G
E
K
L
L
S
S
I
P
M
W
T
T
Site 23
S224
Q
G
E
K
L
L
S
S
I
P
M
W
T
T
F
Site 24
S245
Y
N
C
T
R
T
A
S
V
K
A
I
T
N
V
Site 25
T269
F
Q
N
I
M
R
R
T
A
Q
A
R
D
E
Q
Site 26
Y277
A
Q
A
R
D
E
Q
Y
R
N
F
L
R
S
V
Site 27
S283
Q
Y
R
N
F
L
R
S
V
S
L
L
K
N
L
Site 28
S285
R
N
F
L
R
S
V
S
L
L
K
N
L
P
E
Site 29
T296
N
L
P
E
D
K
L
T
K
I
I
D
C
L
E
Site 30
Y306
I
D
C
L
E
V
E
Y
Y
D
K
G
D
Y
I
Site 31
Y307
D
C
L
E
V
E
Y
Y
D
K
G
D
Y
I
I
Site 32
Y312
E
Y
Y
D
K
G
D
Y
I
I
R
E
G
E
E
Site 33
T322
R
E
G
E
E
G
S
T
F
F
I
L
A
K
G
Site 34
T334
A
K
G
K
V
K
V
T
Q
S
T
E
G
H
D
Site 35
S336
G
K
V
K
V
T
Q
S
T
E
G
H
D
Q
P
Site 36
T348
D
Q
P
Q
L
I
K
T
L
Q
K
G
E
Y
F
Site 37
Y354
K
T
L
Q
K
G
E
Y
F
G
E
K
A
L
I
Site 38
S362
F
G
E
K
A
L
I
S
D
D
V
R
S
A
N
Site 39
T390
D
R
E
T
F
N
Q
T
V
G
T
F
E
E
L
Site 40
T393
T
F
N
Q
T
V
G
T
F
E
E
L
Q
K
Y
Site 41
Y400
T
F
E
E
L
Q
K
Y
L
E
G
Y
V
A
N
Site 42
Y404
L
Q
K
Y
L
E
G
Y
V
A
N
L
N
R
D
Site 43
S420
E
K
R
H
A
K
R
S
M
S
N
W
K
L
S
Site 44
S422
R
H
A
K
R
S
M
S
N
W
K
L
S
K
A
Site 45
S427
S
M
S
N
W
K
L
S
K
A
L
S
L
E
M
Site 46
S431
W
K
L
S
K
A
L
S
L
E
M
I
Q
L
K
Site 47
S445
K
E
K
V
A
R
F
S
S
S
S
P
F
Q
N
Site 48
S446
E
K
V
A
R
F
S
S
S
S
P
F
Q
N
L
Site 49
S447
K
V
A
R
F
S
S
S
S
P
F
Q
N
L
E
Site 50
S448
V
A
R
F
S
S
S
S
P
F
Q
N
L
E
I
Site 51
T492
R
K
K
H
I
V
D
T
K
Q
Q
E
H
V
Y
Site 52
S500
K
Q
Q
E
H
V
Y
S
E
K
R
I
L
E
E
Site 53
Y517
S
P
F
I
V
K
L
Y
R
T
F
K
D
N
K
Site 54
T519
F
I
V
K
L
Y
R
T
F
K
D
N
K
Y
V
Site 55
Y525
R
T
F
K
D
N
K
Y
V
Y
M
L
L
E
A
Site 56
S540
C
L
G
G
E
L
W
S
I
L
R
D
R
G
S
Site 57
S547
S
I
L
R
D
R
G
S
F
D
E
P
T
S
K
Site 58
T552
R
G
S
F
D
E
P
T
S
K
F
C
V
A
C
Site 59
Y574
L
H
R
L
G
I
I
Y
R
D
L
K
P
E
N
Site 60
S603
G
F
A
K
K
I
G
S
G
Q
K
T
W
T
F
Site 61
T607
K
I
G
S
G
Q
K
T
W
T
F
C
G
T
P
Site 62
T609
G
S
G
Q
K
T
W
T
F
C
G
T
P
E
Y
Site 63
T613
K
T
W
T
F
C
G
T
P
E
Y
V
A
P
E
Site 64
S630
L
N
K
G
H
D
F
S
V
D
F
W
S
L
G
Site 65
S651
L
T
G
N
P
P
F
S
G
V
D
Q
M
M
T
Site 66
T676
M
D
F
P
R
K
I
T
R
R
P
E
D
L
I
Site 67
S723
W
E
G
L
K
A
R
S
L
P
S
P
L
Q
R
Site 68
S726
L
K
A
R
S
L
P
S
P
L
Q
R
E
L
K
Site 69
S739
L
K
G
P
I
D
H
S
Y
F
D
K
Y
P
P
Site 70
Y740
K
G
P
I
D
H
S
Y
F
D
K
Y
P
P
E
Site 71
Y744
D
H
S
Y
F
D
K
Y
P
P
E
K
G
M
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation