KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
NFATC2
Full Name:
Nuclear factor of activated T-cells, cytoplasmic 2
Alias:
NFAC2; NFAT pre-existing subunit; NFAT1; NFATP; NF-ATp; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1
Type:
Transcription protein
Mass (Da):
100146
Number AA:
925
UniProt ID:
Q13469
International Prot ID:
IPI00247309
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0016563
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
GO:0045941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
P
G
H
E
P
G
G
S
P
Q
D
E
L
D
F
Site 2
S31
P
Q
D
E
L
D
F
S
I
L
F
D
Y
E
Y
Site 3
Y36
D
F
S
I
L
F
D
Y
E
Y
L
N
P
N
E
Site 4
Y38
S
I
L
F
D
Y
E
Y
L
N
P
N
E
E
E
Site 5
S53
P
N
A
H
K
V
A
S
P
P
S
G
P
A
Y
Site 6
S56
H
K
V
A
S
P
P
S
G
P
A
Y
P
D
D
Site 7
Y60
S
P
P
S
G
P
A
Y
P
D
D
V
L
D
Y
Site 8
Y67
Y
P
D
D
V
L
D
Y
G
L
K
P
Y
S
P
Site 9
S73
D
Y
G
L
K
P
Y
S
P
L
A
S
L
S
G
Site 10
S77
K
P
Y
S
P
L
A
S
L
S
G
E
P
P
G
Site 11
S79
Y
S
P
L
A
S
L
S
G
E
P
P
G
R
F
Site 12
S99
V
G
P
Q
K
F
L
S
A
A
K
P
A
G
A
Site 13
S110
P
A
G
A
S
G
L
S
P
R
I
E
I
T
P
Site 14
T116
L
S
P
R
I
E
I
T
P
S
H
E
L
I
Q
Site 15
S118
P
R
I
E
I
T
P
S
H
E
L
I
Q
A
V
Site 16
S148
P
L
A
G
V
A
A
S
P
R
F
T
L
P
V
Site 17
Y161
P
V
P
G
F
E
G
Y
R
E
P
L
C
L
S
Site 18
S168
Y
R
E
P
L
C
L
S
P
A
S
S
G
S
S
Site 19
S171
P
L
C
L
S
P
A
S
S
G
S
S
A
S
F
Site 20
S172
L
C
L
S
P
A
S
S
G
S
S
A
S
F
I
Site 21
S174
L
S
P
A
S
S
G
S
S
A
S
F
I
S
D
Site 22
S175
S
P
A
S
S
G
S
S
A
S
F
I
S
D
T
Site 23
S177
A
S
S
G
S
S
A
S
F
I
S
D
T
F
S
Site 24
S180
G
S
S
A
S
F
I
S
D
T
F
S
P
Y
T
Site 25
T182
S
A
S
F
I
S
D
T
F
S
P
Y
T
S
P
Site 26
Y186
I
S
D
T
F
S
P
Y
T
S
P
C
V
S
P
Site 27
T187
S
D
T
F
S
P
Y
T
S
P
C
V
S
P
N
Site 28
S188
D
T
F
S
P
Y
T
S
P
C
V
S
P
N
N
Site 29
S192
P
Y
T
S
P
C
V
S
P
N
N
G
G
P
D
Site 30
S213
Q
N
I
P
A
H
Y
S
P
R
T
S
P
I
M
Site 31
T216
P
A
H
Y
S
P
R
T
S
P
I
M
S
P
R
Site 32
S217
A
H
Y
S
P
R
T
S
P
I
M
S
P
R
T
Site 33
S221
P
R
T
S
P
I
M
S
P
R
T
S
L
A
E
Site 34
T224
S
P
I
M
S
P
R
T
S
L
A
E
D
S
C
Site 35
S225
P
I
M
S
P
R
T
S
L
A
E
D
S
C
L
Site 36
S230
R
T
S
L
A
E
D
S
C
L
G
R
H
S
P
Site 37
S236
D
S
C
L
G
R
H
S
P
V
P
R
P
A
S
Site 38
S243
S
P
V
P
R
P
A
S
R
S
S
S
P
G
A
Site 39
S245
V
P
R
P
A
S
R
S
S
S
P
G
A
K
R
Site 40
S246
P
R
P
A
S
R
S
S
S
P
G
A
K
R
R
Site 41
S247
R
P
A
S
R
S
S
S
P
G
A
K
R
R
H
Site 42
S255
P
G
A
K
R
R
H
S
C
A
E
A
L
V
A
Site 43
S268
V
A
L
P
P
G
A
S
P
Q
R
S
R
S
P
Site 44
S272
P
G
A
S
P
Q
R
S
R
S
P
S
P
Q
P
Site 45
S274
A
S
P
Q
R
S
R
S
P
S
P
Q
P
S
S
Site 46
S276
P
Q
R
S
R
S
P
S
P
Q
P
S
S
H
V
Site 47
S280
R
S
P
S
P
Q
P
S
S
H
V
A
P
Q
D
Site 48
S281
S
P
S
P
Q
P
S
S
H
V
A
P
Q
D
H
Site 49
S290
V
A
P
Q
D
H
G
S
P
A
G
Y
P
P
V
Site 50
Y294
D
H
G
S
P
A
G
Y
P
P
V
A
G
S
A
Site 51
T312
D
A
L
N
S
L
A
T
D
S
P
C
G
I
P
Site 52
S314
L
N
S
L
A
T
D
S
P
C
G
I
P
P
K
Site 53
T325
I
P
P
K
M
W
K
T
S
P
D
P
S
P
V
Site 54
S326
P
P
K
M
W
K
T
S
P
D
P
S
P
V
S
Site 55
S330
W
K
T
S
P
D
P
S
P
V
S
A
A
P
S
Site 56
S333
S
P
D
P
S
P
V
S
A
A
P
S
K
A
G
Site 57
S337
S
P
V
S
A
A
P
S
K
A
G
L
P
R
H
Site 58
Y346
A
G
L
P
R
H
I
Y
P
A
V
E
F
L
G
Site 59
S363
E
Q
G
E
R
R
N
S
A
P
E
S
I
L
L
Site 60
S367
R
R
N
S
A
P
E
S
I
L
L
V
P
P
T
Site 61
T374
S
I
L
L
V
P
P
T
W
P
K
P
L
V
P
Site 62
S402
P
P
L
E
W
P
L
S
S
Q
S
G
S
Y
E
Site 63
S403
P
L
E
W
P
L
S
S
Q
S
G
S
Y
E
L
Site 64
S405
E
W
P
L
S
S
Q
S
G
S
Y
E
L
R
I
Site 65
S407
P
L
S
S
Q
S
G
S
Y
E
L
R
I
E
V
Site 66
Y424
K
P
H
H
R
A
H
Y
E
T
E
G
S
R
G
Site 67
T426
H
H
R
A
H
Y
E
T
E
G
S
R
G
A
V
Site 68
S429
A
H
Y
E
T
E
G
S
R
G
A
V
K
A
P
Site 69
Y448
P
V
V
Q
L
H
G
Y
M
E
N
K
P
L
G
Site 70
T480
F
Y
Q
V
H
R
I
T
G
K
T
V
T
T
T
Site 71
T483
V
H
R
I
T
G
K
T
V
T
T
T
S
Y
E
Site 72
T485
R
I
T
G
K
T
V
T
T
T
S
Y
E
K
I
Site 73
S488
G
K
T
V
T
T
T
S
Y
E
K
I
V
G
N
Site 74
Y489
K
T
V
T
T
T
S
Y
E
K
I
V
G
N
T
Site 75
T512
P
K
N
N
M
R
A
T
I
D
C
A
G
I
L
Site 76
T540
T
D
I
G
R
K
N
T
R
V
R
L
V
F
R
Site 77
S554
R
V
H
I
P
E
S
S
G
R
I
V
S
L
Q
Site 78
S559
E
S
S
G
R
I
V
S
L
Q
T
A
S
N
P
Site 79
S564
I
V
S
L
Q
T
A
S
N
P
I
E
C
S
Q
Site 80
S570
A
S
N
P
I
E
C
S
Q
R
S
A
H
E
L
Site 81
S573
P
I
E
C
S
Q
R
S
A
H
E
L
P
M
V
Site 82
T585
P
M
V
E
R
Q
D
T
D
S
C
L
V
Y
G
Site 83
S587
V
E
R
Q
D
T
D
S
C
L
V
Y
G
G
Q
Site 84
T599
G
G
Q
Q
M
I
L
T
G
Q
N
F
T
S
E
Site 85
S605
L
T
G
Q
N
F
T
S
E
S
K
V
V
F
T
Site 86
S607
G
Q
N
F
T
S
E
S
K
V
V
F
T
E
K
Site 87
T615
K
V
V
F
T
E
K
T
T
D
G
Q
Q
I
W
Site 88
T616
V
V
F
T
E
K
T
T
D
G
Q
Q
I
W
E
Site 89
T627
Q
I
W
E
M
E
A
T
V
D
K
D
K
S
Q
Site 90
S633
A
T
V
D
K
D
K
S
Q
P
N
M
L
F
V
Site 91
Y645
L
F
V
E
I
P
E
Y
R
N
K
H
I
R
T
Site 92
T652
Y
R
N
K
H
I
R
T
P
V
K
V
N
F
Y
Site 93
Y659
T
P
V
K
V
N
F
Y
V
I
N
G
K
R
K
Site 94
S668
I
N
G
K
R
K
R
S
Q
P
Q
H
F
T
Y
Site 95
T674
R
S
Q
P
Q
H
F
T
Y
H
P
V
P
A
I
Site 96
Y675
S
Q
P
Q
H
F
T
Y
H
P
V
P
A
I
K
Site 97
Y689
K
T
E
P
T
D
E
Y
D
P
T
L
I
C
S
Site 98
T692
P
T
D
E
Y
D
P
T
L
I
C
S
P
T
H
Site 99
S696
Y
D
P
T
L
I
C
S
P
T
H
G
G
L
G
Site 100
T698
P
T
L
I
C
S
P
T
H
G
G
L
G
S
Q
Site 101
S704
P
T
H
G
G
L
G
S
Q
P
Y
Y
P
Q
H
Site 102
Y707
G
G
L
G
S
Q
P
Y
Y
P
Q
H
P
M
V
Site 103
Y708
G
L
G
S
Q
P
Y
Y
P
Q
H
P
M
V
A
Site 104
T733
A
P
C
Q
Q
F
R
T
G
L
S
S
P
D
A
Site 105
S737
Q
F
R
T
G
L
S
S
P
D
A
R
Y
Q
Q
Site 106
Y742
L
S
S
P
D
A
R
Y
Q
Q
Q
N
P
A
A
Site 107
Y752
Q
N
P
A
A
V
L
Y
Q
R
S
K
S
L
S
Site 108
S755
A
A
V
L
Y
Q
R
S
K
S
L
S
P
S
L
Site 109
S757
V
L
Y
Q
R
S
K
S
L
S
P
S
L
L
G
Site 110
S759
Y
Q
R
S
K
S
L
S
P
S
L
L
G
Y
Q
Site 111
S761
R
S
K
S
L
S
P
S
L
L
G
Y
Q
Q
P
Site 112
S776
A
L
M
A
A
P
L
S
L
A
D
A
H
R
S
Site 113
S794
H
A
G
S
Q
G
Q
S
S
A
L
L
H
P
S
Site 114
S795
A
G
S
Q
G
Q
S
S
A
L
L
H
P
S
P
Site 115
S801
S
S
A
L
L
H
P
S
P
T
N
Q
Q
A
S
Site 116
S808
S
P
T
N
Q
Q
A
S
P
V
I
H
Y
S
P
Site 117
S814
A
S
P
V
I
H
Y
S
P
T
N
Q
Q
L
R
Site 118
T841
C
E
N
F
A
P
G
T
T
R
P
G
P
P
P
Site 119
S850
R
P
G
P
P
P
V
S
Q
G
Q
R
L
S
P
Site 120
S856
V
S
Q
G
Q
R
L
S
P
G
S
Y
P
T
V
Site 121
S859
G
Q
R
L
S
P
G
S
Y
P
T
V
I
Q
Q
Site 122
Y860
Q
R
L
S
P
G
S
Y
P
T
V
I
Q
Q
Q
Site 123
S871
I
Q
Q
Q
N
A
T
S
Q
R
A
A
K
N
G
Site 124
S882
A
K
N
G
P
P
V
S
D
Q
K
E
V
L
P
Site 125
T893
E
V
L
P
A
G
V
T
I
K
Q
E
Q
N
L
Site 126
Y904
E
Q
N
L
D
Q
T
Y
L
D
D
V
N
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation