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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DGK-Z
Full Name:
Diacylglycerol kinase zeta
Alias:
Diglyceride kinase zeta;DGK-zeta;DAG kinase zeta
Type:
Kinase, lipid
Mass (Da):
124122
Number AA:
1117
UniProt ID:
Q13574
International Prot ID:
IPI00013835
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004143
GO:0001727
PhosphoSite+
KinaseNET
Biological Process:
GO:0031571
GO:0007205
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
G
E
G
Q
Q
R
P
S
S
V
G
L
P
T
G
Site 2
S25
E
G
Q
Q
R
P
S
S
V
G
L
P
T
G
K
Site 3
S37
T
G
K
A
R
R
R
S
P
A
G
Q
A
S
S
Site 4
S43
R
S
P
A
G
Q
A
S
S
S
L
A
Q
R
R
Site 5
S45
P
A
G
Q
A
S
S
S
L
A
Q
R
R
R
S
Site 6
S52
S
L
A
Q
R
R
R
S
S
A
Q
L
Q
G
C
Site 7
S53
L
A
Q
R
R
R
S
S
A
Q
L
Q
G
C
L
Site 8
S70
C
G
V
R
A
Q
G
S
S
R
R
R
S
S
T
Site 9
S71
G
V
R
A
Q
G
S
S
R
R
R
S
S
T
V
Site 10
S75
Q
G
S
S
R
R
R
S
S
T
V
P
P
S
C
Site 11
S76
G
S
S
R
R
R
S
S
T
V
P
P
S
C
N
Site 12
T77
S
S
R
R
R
S
S
T
V
P
P
S
C
N
P
Site 13
S81
R
S
S
T
V
P
P
S
C
N
P
R
F
I
V
Site 14
T138
S
S
A
I
Q
P
G
T
K
T
P
G
P
P
P
Site 15
T140
A
I
Q
P
G
T
K
T
P
G
P
P
P
P
R
Site 16
Y158
P
L
L
P
L
P
R
Y
L
R
R
A
S
S
H
Site 17
S163
P
R
Y
L
R
R
A
S
S
H
L
L
P
A
D
Site 18
S164
R
Y
L
R
R
A
S
S
H
L
L
P
A
D
A
Site 19
Y173
L
L
P
A
D
A
V
Y
D
H
A
L
W
G
L
Site 20
Y183
A
L
W
G
L
H
G
Y
Y
R
R
L
S
Q
R
Site 21
Y184
L
W
G
L
H
G
Y
Y
R
R
L
S
Q
R
R
Site 22
S188
H
G
Y
Y
R
R
L
S
Q
R
R
P
S
G
Q
Site 23
S193
R
L
S
Q
R
R
P
S
G
Q
H
P
G
P
G
Site 24
S205
G
P
G
G
R
R
A
S
G
T
T
A
G
T
M
Site 25
T207
G
G
R
R
A
S
G
T
T
A
G
T
M
L
P
Site 26
T211
A
S
G
T
T
A
G
T
M
L
P
T
R
V
R
Site 27
T215
T
A
G
T
M
L
P
T
R
V
R
P
L
S
R
Site 28
S221
P
T
R
V
R
P
L
S
R
R
R
Q
V
A
L
Site 29
T260
H
L
A
P
P
P
P
T
P
G
A
P
C
S
E
Site 30
S266
P
T
P
G
A
P
C
S
E
S
E
R
Q
I
R
Site 31
S268
P
G
A
P
C
S
E
S
E
R
Q
I
R
S
T
Site 32
T275
S
E
R
Q
I
R
S
T
V
D
W
S
E
S
A
Site 33
S281
S
T
V
D
W
S
E
S
A
T
Y
G
E
H
I
Site 34
Y284
D
W
S
E
S
A
T
Y
G
E
H
I
W
F
E
Site 35
S313
C
V
A
R
M
L
K
S
V
S
R
R
K
C
A
Site 36
S315
A
R
M
L
K
S
V
S
R
R
K
C
A
A
C
Site 37
S344
I
N
F
R
C
K
P
S
F
R
E
S
G
S
R
Site 38
S348
C
K
P
S
F
R
E
S
G
S
R
N
V
R
E
Site 39
T357
S
R
N
V
R
E
P
T
F
V
R
H
H
W
V
Site 40
T385
K
G
F
Q
Q
K
F
T
F
H
S
K
E
I
V
Site 41
T443
R
A
R
R
P
Q
N
T
L
K
A
S
K
K
K
Site 42
S447
P
Q
N
T
L
K
A
S
K
K
K
K
R
A
S
Site 43
S454
S
K
K
K
K
R
A
S
F
K
R
K
S
S
K
Site 44
S459
R
A
S
F
K
R
K
S
S
K
K
G
P
E
E
Site 45
S460
A
S
F
K
R
K
S
S
K
K
G
P
E
E
G
Site 46
T477
R
P
F
I
I
R
P
T
P
S
P
L
M
K
P
Site 47
S493
L
V
F
V
N
P
K
S
G
G
N
Q
G
A
K
Site 48
Y508
I
I
Q
S
F
L
W
Y
L
N
P
R
Q
V
F
Site 49
S518
P
R
Q
V
F
D
L
S
Q
G
G
P
K
E
A
Site 50
Y529
P
K
E
A
L
E
M
Y
R
K
V
H
N
L
R
Site 51
T578
T
G
N
D
L
A
R
T
L
N
W
G
G
G
Y
Site 52
T586
L
N
W
G
G
G
Y
T
D
E
P
V
S
K
I
Site 53
S591
G
Y
T
D
E
P
V
S
K
I
L
S
H
V
E
Site 54
S595
E
P
V
S
K
I
L
S
H
V
E
E
G
N
V
Site 55
T628
E
D
R
D
E
G
A
T
D
R
L
P
L
D
V
Site 56
T649
L
G
F
D
A
H
V
T
L
E
F
H
E
S
R
Site 57
S655
V
T
L
E
F
H
E
S
R
E
A
N
P
E
K
Site 58
Y673
R
F
R
N
K
M
F
Y
A
G
T
A
F
S
D
Site 59
S685
F
S
D
F
L
M
G
S
S
K
D
L
A
K
H
Site 60
T703
V
C
D
G
M
D
L
T
P
K
I
Q
D
L
K
Site 61
Y747
P
Q
R
H
D
D
G
Y
L
E
V
I
G
F
T
Site 62
T771
G
G
H
G
E
R
L
T
Q
C
R
E
V
V
L
Site 63
S798
E
P
C
K
L
A
A
S
R
I
R
I
A
L
R
Site 64
S818
V
Q
K
A
K
R
R
S
A
A
P
L
H
S
D
Site 65
S838
E
Q
L
R
I
Q
V
S
R
V
S
M
H
D
Y
Site 66
S841
R
I
Q
V
S
R
V
S
M
H
D
Y
E
A
L
Site 67
Y845
S
R
V
S
M
H
D
Y
E
A
L
H
Y
D
K
Site 68
Y850
H
D
Y
E
A
L
H
Y
D
K
E
Q
L
K
E
Site 69
S859
K
E
Q
L
K
E
A
S
V
P
L
G
T
V
V
Site 70
S894
P
D
G
A
G
A
K
S
P
T
C
Q
K
L
S
Site 71
Y916
A
T
T
A
S
R
F
Y
R
I
D
R
A
Q
E
Site 72
Y927
R
A
Q
E
H
L
N
Y
V
T
E
I
A
Q
D
Site 73
S947
D
P
E
L
L
G
A
S
A
R
P
D
L
P
T
Site 74
T954
S
A
R
P
D
L
P
T
P
T
S
P
L
P
T
Site 75
S957
P
D
L
P
T
P
T
S
P
L
P
T
S
P
C
Site 76
T961
T
P
T
S
P
L
P
T
S
P
C
S
P
T
P
Site 77
S962
P
T
S
P
L
P
T
S
P
C
S
P
T
P
R
Site 78
S965
P
L
P
T
S
P
C
S
P
T
P
R
S
L
Q
Site 79
T967
P
T
S
P
C
S
P
T
P
R
S
L
Q
G
D
Site 80
S970
P
C
S
P
T
P
R
S
L
Q
G
D
A
A
P
Site 81
S1012
L
M
H
R
D
E
Q
S
R
T
L
L
H
H
A
Site 82
T1014
H
R
D
E
Q
S
R
T
L
L
H
H
A
V
S
Site 83
S1024
H
H
A
V
S
T
G
S
K
D
V
V
R
Y
L
Site 84
Y1065
G
Q
R
T
I
C
H
Y
I
V
E
A
G
A
S
Site 85
S1072
Y
I
V
E
A
G
A
S
L
M
K
T
D
Q
Q
Site 86
T1076
A
G
A
S
L
M
K
T
D
Q
Q
G
D
T
P
Site 87
T1082
K
T
D
Q
Q
G
D
T
P
R
Q
R
A
E
K
Site 88
Y1098
Q
D
T
E
L
A
A
Y
L
E
N
R
Q
H
Y
Site 89
Y1105
Y
L
E
N
R
Q
H
Y
Q
M
I
Q
R
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation