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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THOC5
Full Name:
THO complex subunit 5 homolog
Alias:
C22orf19; CV019; CV19; Fmip; Fms-interacting protein; FSAP79; Functional spliceosome-associated protein 79; HTREX90; KIAA0983; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; THO complex 5; THO complex subunit 5 homolog: NF2/meningioma region protein pK1.3: Placental protein 39.2
Type:
Cell development/differentiation
Mass (Da):
78508
Number AA:
683
UniProt ID:
Q13769
International Prot ID:
IPI00299417
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000445
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0046784
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
S
E
S
S
K
K
R
K
P
K
Site 2
S6
_
_
M
S
S
E
S
S
K
K
R
K
P
K
V
Site 3
S16
R
K
P
K
V
I
R
S
D
G
A
P
A
E
G
Site 4
S28
A
E
G
K
R
N
R
S
D
T
E
Q
E
G
K
Site 5
T30
G
K
R
N
R
S
D
T
E
Q
E
G
K
Y
Y
Site 6
Y36
D
T
E
Q
E
G
K
Y
Y
S
E
E
A
E
V
Site 7
Y37
T
E
Q
E
G
K
Y
Y
S
E
E
A
E
V
D
Site 8
S38
E
Q
E
G
K
Y
Y
S
E
E
A
E
V
D
L
Site 9
Y52
L
R
D
P
G
R
D
Y
E
L
Y
K
Y
T
C
Site 10
Y55
P
G
R
D
Y
E
L
Y
K
Y
T
C
Q
E
L
Site 11
Y57
R
D
Y
E
L
Y
K
Y
T
C
Q
E
L
Q
R
Site 12
S74
A
E
I
Q
D
L
K
S
R
G
G
K
D
V
A
Site 13
T116
L
K
K
G
R
D
Q
T
H
E
A
K
Q
K
V
Site 14
Y126
A
K
Q
K
V
D
A
Y
H
L
Q
L
Q
N
L
Site 15
Y135
L
Q
L
Q
N
L
L
Y
E
V
M
H
L
Q
K
Site 16
S152
T
K
C
L
E
F
K
S
K
H
E
E
I
D
L
Site 17
S161
H
E
E
I
D
L
V
S
L
E
E
F
Y
K
E
Site 18
T187
M
G
D
P
H
Q
Q
T
L
A
R
L
D
W
E
Site 19
Y205
R
K
R
L
A
E
K
Y
R
E
C
L
S
N
K
Site 20
S210
E
K
Y
R
E
C
L
S
N
K
E
K
I
L
K
Site 21
Y225
E
I
E
V
K
K
E
Y
L
S
S
L
Q
P
R
Site 22
S228
V
K
K
E
Y
L
S
S
L
Q
P
R
L
N
S
Site 23
S235
S
L
Q
P
R
L
N
S
I
M
Q
A
S
L
P
Site 24
T260
Q
A
H
K
Q
Y
E
T
A
R
H
L
P
P
P
Site 25
T285
Y
G
Q
A
C
D
K
T
L
S
V
A
I
E
G
Site 26
S293
L
S
V
A
I
E
G
S
V
D
E
A
K
A
L
Site 27
S307
L
F
K
P
P
E
D
S
Q
D
D
E
S
D
S
Site 28
S312
E
D
S
Q
D
D
E
S
D
S
D
A
E
E
E
Site 29
S314
S
Q
D
D
E
S
D
S
D
A
E
E
E
Q
T
Site 30
T321
S
D
A
E
E
E
Q
T
T
K
R
R
R
P
T
Site 31
T322
D
A
E
E
E
Q
T
T
K
R
R
R
P
T
L
Site 32
T328
T
T
K
R
R
R
P
T
L
G
V
Q
L
D
D
Site 33
S347
M
L
K
R
H
P
L
S
V
M
L
D
L
K
C
Site 34
S358
D
L
K
C
K
D
D
S
V
L
H
L
T
F
Y
Site 35
S402
L
S
P
D
S
V
L
S
C
L
Y
P
G
D
H
Site 36
Y405
D
S
V
L
S
C
L
Y
P
G
D
H
G
K
K
Site 37
T413
P
G
D
H
G
K
K
T
P
N
P
A
N
Q
Y
Site 38
Y420
T
P
N
P
A
N
Q
Y
Q
F
D
K
V
G
I
Site 39
S466
Q
T
V
I
A
D
H
S
L
S
A
S
H
M
E
Site 40
S468
V
I
A
D
H
S
L
S
A
S
H
M
E
T
T
Site 41
S470
A
D
H
S
L
S
A
S
H
M
E
T
T
M
K
Site 42
T474
L
S
A
S
H
M
E
T
T
M
K
L
L
K
T
Site 43
T481
T
T
M
K
L
L
K
T
R
V
Q
S
R
L
A
Site 44
S485
L
L
K
T
R
V
Q
S
R
L
A
L
H
K
Q
Site 45
T524
S
R
L
V
K
W
V
T
V
A
H
E
D
Y
M
Site 46
Y530
V
T
V
A
H
E
D
Y
M
E
L
H
F
T
K
Site 47
Y552
A
G
D
T
N
L
Y
Y
M
A
L
I
E
R
G
Site 48
T591
L
N
W
K
G
E
K
T
N
S
N
D
D
N
I
Site 49
S593
W
K
G
E
K
T
N
S
N
D
D
N
I
R
A
Site 50
Y609
E
G
E
V
N
V
C
Y
K
E
L
C
G
P
W
Site 51
S641
D
V
Y
L
E
T
E
S
H
D
D
S
V
E
G
Site 52
S645
E
T
E
S
H
D
D
S
V
E
G
P
K
E
F
Site 53
S666
L
R
L
F
R
G
P
S
R
M
K
P
F
K
Y
Site 54
Y673
S
R
M
K
P
F
K
Y
N
H
P
Q
G
F
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation