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Updated November 2019
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Protein Info
Short Name:
SPTAN1
Full Name:
Spectrin alpha chain, brain
Alias:
Alpha-fodrin; Alpha-II spectrin; Fodrin alpha; Fodrin alpha chain; SPCN; Spectrin alpha II; Spectrin alpha, brain; Spectrin, alpha, non-erythrocytic 1; Spectrin, non-erythroid alpha; SPNA2; SPTA2
Type:
Adaptor/scaffold; Cytoskeletal protein
Mass (Da):
284539
Number AA:
2472
UniProt ID:
Q13813
International Prot ID:
IPI00413728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005624
GO:0008091
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005509
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0051693
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
R
Q
Q
V
L
D
R
Y
H
R
F
K
E
L
S
Site 2
S33
Y
H
R
F
K
E
L
S
T
L
R
R
Q
K
L
Site 3
T34
H
R
F
K
E
L
S
T
L
R
R
Q
K
L
E
Site 4
S43
R
R
Q
K
L
E
D
S
Y
R
F
Q
F
F
Q
Site 5
Y44
R
Q
K
L
E
D
S
Y
R
F
Q
F
F
Q
R
Site 6
Y72
Q
I
A
S
D
E
N
Y
K
D
P
T
N
L
Q
Site 7
T76
D
E
N
Y
K
D
P
T
N
L
Q
G
K
L
Q
Site 8
S111
E
T
G
N
L
M
I
S
E
G
H
F
A
S
E
Site 9
S117
I
S
E
G
H
F
A
S
E
T
I
R
T
R
L
Site 10
T119
E
G
H
F
A
S
E
T
I
R
T
R
L
M
E
Site 11
T122
F
A
S
E
T
I
R
T
R
L
M
E
L
H
R
Site 12
Y154
Q
A
Q
K
L
V
Q
Y
L
R
E
C
E
D
V
Site 13
T173
N
D
K
E
A
I
V
T
S
E
E
L
G
Q
D
Site 14
T196
K
K
F
E
E
F
Q
T
D
M
A
A
H
E
E
Site 15
T228
P
E
E
E
L
I
K
T
K
Q
D
E
V
N
A
Site 16
T267
F
N
R
D
V
D
E
T
I
S
W
I
K
E
K
Site 17
S280
E
K
E
Q
L
M
A
S
D
D
F
G
R
D
L
Site 18
S289
D
F
G
R
D
L
A
S
V
Q
A
L
L
R
K
Site 19
S324
E
A
D
R
L
Q
Q
S
H
P
L
S
A
T
Q
Site 20
S328
L
Q
Q
S
H
P
L
S
A
T
Q
I
Q
V
K
Site 21
T341
V
K
R
E
E
L
I
T
N
W
E
Q
I
R
T
Site 22
T348
T
N
W
E
Q
I
R
T
L
A
A
E
R
H
A
Site 23
S360
R
H
A
R
L
N
D
S
Y
R
L
Q
R
F
L
Site 24
Y361
H
A
R
L
N
D
S
Y
R
L
Q
R
F
L
A
Site 25
T374
L
A
D
F
R
D
L
T
S
W
V
T
E
M
K
Site 26
S391
I
N
A
D
E
L
A
S
D
V
A
G
A
E
A
Site 27
S416
E
I
D
A
H
E
D
S
F
K
S
A
D
E
S
Site 28
S419
A
H
E
D
S
F
K
S
A
D
E
S
G
Q
A
Site 29
S423
S
F
K
S
A
D
E
S
G
Q
A
L
L
A
A
Site 30
S435
L
A
A
G
H
Y
A
S
D
E
V
R
E
K
L
Site 31
T443
D
E
V
R
E
K
L
T
V
L
S
E
E
R
A
Site 32
Y463
W
E
L
R
R
Q
Q
Y
E
Q
C
M
D
L
Q
Site 33
S498
L
N
E
D
L
G
D
S
L
D
S
V
E
A
L
Site 34
S501
D
L
G
D
S
L
D
S
V
E
A
L
L
K
K
Site 35
S515
K
H
E
D
F
E
K
S
L
S
A
Q
E
E
K
Site 36
S517
E
D
F
E
K
S
L
S
A
Q
E
E
K
I
T
Site 37
T524
S
A
Q
E
E
K
I
T
A
L
D
E
F
A
T
Site 38
T546
Y
A
M
E
D
V
A
T
R
R
D
A
L
L
S
Site 39
S553
T
R
R
D
A
L
L
S
R
R
N
A
L
H
E
Site 40
S572
R
R
A
Q
L
A
D
S
F
H
L
Q
Q
F
F
Site 41
S582
L
Q
Q
F
F
R
D
S
D
E
L
K
S
W
V
Site 42
S587
R
D
S
D
E
L
K
S
W
V
N
E
K
M
K
Site 43
T595
W
V
N
E
K
M
K
T
A
T
D
E
A
Y
K
Site 44
Y601
K
T
A
T
D
E
A
Y
K
D
P
S
N
L
Q
Site 45
S605
D
E
A
Y
K
D
P
S
N
L
Q
G
K
V
Q
Site 46
S622
Q
A
F
E
A
E
L
S
A
N
Q
S
R
I
D
Site 47
S626
A
E
L
S
A
N
Q
S
R
I
D
A
L
E
K
Site 48
Y644
K
L
I
D
V
N
H
Y
A
K
D
E
V
A
A
Site 49
S658
A
R
M
N
E
V
I
S
L
W
K
K
L
L
E
Site 50
T667
W
K
K
L
L
E
A
T
E
L
K
G
I
K
L
Site 51
Y695
E
D
I
E
L
W
L
Y
E
V
E
G
H
L
A
Site 52
Y706
G
H
L
A
S
D
D
Y
G
K
D
L
T
N
V
Site 53
T711
D
D
Y
G
K
D
L
T
N
V
Q
N
L
Q
K
Site 54
T738
Q
D
R
I
D
G
I
T
I
Q
A
R
Q
F
Q
Site 55
Y766
Q
E
A
L
V
A
R
Y
E
A
L
K
E
P
M
Site 56
S783
R
K
Q
K
L
A
D
S
L
R
L
Q
Q
L
F
Site 57
T798
R
D
V
E
D
E
E
T
W
I
R
E
K
E
P
Site 58
S809
E
K
E
P
I
A
A
S
T
N
R
G
K
D
L
Site 59
T844
E
P
R
I
K
A
V
T
Q
K
G
N
A
M
V
Site 60
S880
E
A
L
K
A
K
A
S
Q
R
R
Q
D
L
E
Site 61
S889
R
R
Q
D
L
E
D
S
L
Q
A
Q
Q
Y
F
Site 62
Y895
D
S
L
Q
A
Q
Q
Y
F
A
D
A
N
E
A
Site 63
S904
A
D
A
N
E
A
E
S
W
M
R
E
K
E
P
Site 64
Y918
P
I
V
G
S
T
D
Y
G
K
D
E
D
S
A
Site 65
S924
D
Y
G
K
D
E
D
S
A
E
A
L
L
K
K
Site 66
S937
K
K
H
E
A
L
M
S
D
L
S
A
Y
G
S
Site 67
S940
E
A
L
M
S
D
L
S
A
Y
G
S
S
I
Q
Site 68
Y942
L
M
S
D
L
S
A
Y
G
S
S
I
Q
A
L
Site 69
S944
S
D
L
S
A
Y
G
S
S
I
Q
A
L
R
E
Site 70
S955
A
L
R
E
Q
A
Q
S
C
R
Q
Q
V
A
P
Site 71
T967
V
A
P
T
D
D
E
T
G
K
E
L
V
L
A
Site 72
Y976
K
E
L
V
L
A
L
Y
D
Y
Q
E
K
S
P
Site 73
Y978
L
V
L
A
L
Y
D
Y
Q
E
K
S
P
R
E
Site 74
S982
L
Y
D
Y
Q
E
K
S
P
R
E
V
T
M
K
Site 75
T987
E
K
S
P
R
E
V
T
M
K
K
G
D
I
L
Site 76
T995
M
K
K
G
D
I
L
T
L
L
N
S
T
N
K
Site 77
S999
D
I
L
T
L
L
N
S
T
N
K
D
W
W
K
Site 78
Y1020
Q
G
F
V
P
A
A
Y
V
K
K
L
D
P
A
Site 79
S1029
K
K
L
D
P
A
Q
S
A
S
R
E
N
L
L
Site 80
S1031
L
D
P
A
Q
S
A
S
R
E
N
L
L
E
E
Site 81
S1041
N
L
L
E
E
Q
G
S
I
A
L
R
Q
E
Q
Site 82
T1053
Q
E
Q
I
D
N
Q
T
R
I
T
K
E
A
G
Site 83
T1056
I
D
N
Q
T
R
I
T
K
E
A
G
S
V
S
Site 84
S1061
R
I
T
K
E
A
G
S
V
S
L
R
M
K
Q
Site 85
S1063
T
K
E
A
G
S
V
S
L
R
M
K
Q
V
E
Site 86
Y1073
M
K
Q
V
E
E
L
Y
H
S
L
L
E
L
G
Site 87
S1075
Q
V
E
E
L
Y
H
S
L
L
E
L
G
E
K
Site 88
T1115
N
E
K
E
A
A
L
T
S
E
E
V
G
A
D
Site 89
S1159
K
V
A
E
D
L
E
S
E
G
L
M
A
E
E
Site 90
Y1176
A
V
Q
Q
Q
E
V
Y
G
M
M
P
R
D
E
Site 91
T1184
G
M
M
P
R
D
E
T
D
S
K
T
A
S
P
Site 92
S1186
M
P
R
D
E
T
D
S
K
T
A
S
P
W
K
Site 93
T1188
R
D
E
T
D
S
K
T
A
S
P
W
K
S
A
Site 94
S1190
E
T
D
S
K
T
A
S
P
W
K
S
A
R
L
Site 95
S1194
K
T
A
S
P
W
K
S
A
R
L
M
V
H
T
Site 96
S1217
E
L
N
E
R
W
R
S
L
Q
Q
L
A
E
E
Site 97
S1226
Q
Q
L
A
E
E
R
S
Q
L
L
G
S
A
H
Site 98
T1245
F
H
R
D
A
D
E
T
K
E
W
I
E
E
K
Site 99
T1258
E
K
N
Q
A
L
N
T
D
N
Y
G
H
D
L
Site 100
Y1261
Q
A
L
N
T
D
N
Y
G
H
D
L
A
S
V
Site 101
S1267
N
Y
G
H
D
L
A
S
V
Q
A
L
Q
R
K
Site 102
S1291
A
L
G
D
K
V
N
S
L
G
E
T
A
E
R
Site 103
T1295
K
V
N
S
L
G
E
T
A
E
R
L
I
Q
S
Site 104
S1302
T
A
E
R
L
I
Q
S
H
P
E
S
A
E
D
Site 105
S1306
L
I
Q
S
H
P
E
S
A
E
D
L
Q
E
K
Site 106
S1322
T
E
L
N
Q
A
W
S
S
L
G
K
R
A
D
Site 107
S1323
E
L
N
Q
A
W
S
S
L
G
K
R
A
D
Q
Site 108
S1346
H
D
L
Q
R
F
L
S
D
F
R
D
L
M
S
Site 109
S1353
S
D
F
R
D
L
M
S
W
I
N
G
I
R
G
Site 110
S1363
N
G
I
R
G
L
V
S
S
D
E
L
A
K
D
Site 111
S1364
G
I
R
G
L
V
S
S
D
E
L
A
K
D
V
Site 112
T1372
D
E
L
A
K
D
V
T
G
A
E
A
L
L
E
Site 113
T1386
E
R
H
Q
E
H
R
T
E
I
D
A
R
A
G
Site 114
T1394
E
I
D
A
R
A
G
T
F
Q
A
F
E
Q
F
Site 115
Y1411
Q
L
L
A
H
G
H
Y
A
S
P
E
I
K
Q
Site 116
S1413
L
A
H
G
H
Y
A
S
P
E
I
K
Q
K
L
Site 117
S1476
N
T
E
D
K
G
D
S
L
D
S
V
E
A
L
Site 118
S1479
D
K
G
D
S
L
D
S
V
E
A
L
I
K
K
Site 119
S1523
H
Y
A
K
G
D
I
S
S
R
R
N
E
V
L
Site 120
S1524
Y
A
K
G
D
I
S
S
R
R
N
E
V
L
D
Site 121
S1545
A
Q
M
I
E
K
R
S
K
L
G
E
S
Q
T
Site 122
S1550
K
R
S
K
L
G
E
S
Q
T
L
Q
Q
F
S
Site 123
T1552
S
K
L
G
E
S
Q
T
L
Q
Q
F
S
R
D
Site 124
S1568
D
E
I
E
A
W
I
S
E
K
L
Q
T
A
S
Site 125
T1573
W
I
S
E
K
L
Q
T
A
S
D
E
S
Y
K
Site 126
S1575
S
E
K
L
Q
T
A
S
D
E
S
Y
K
D
P
Site 127
Y1579
Q
T
A
S
D
E
S
Y
K
D
P
T
N
I
Q
Site 128
T1583
D
E
S
Y
K
D
P
T
N
I
Q
S
K
H
Q
Site 129
S1615
G
V
I
D
M
G
N
S
L
I
E
R
G
A
C
Site 130
S1647
W
Q
F
L
V
Q
K
S
A
E
K
S
Q
K
L
Site 131
S1651
V
Q
K
S
A
E
K
S
Q
K
L
K
E
A
N
Site 132
S1692
D
Y
G
K
D
L
A
S
V
N
N
L
L
K
K
Site 133
S1708
Q
L
L
E
A
D
I
S
A
H
E
D
R
L
K
Site 134
S1719
D
R
L
K
D
L
N
S
Q
A
D
S
L
M
T
Site 135
S1723
D
L
N
S
Q
A
D
S
L
M
T
S
S
A
F
Site 136
T1726
S
Q
A
D
S
L
M
T
S
S
A
F
D
T
S
Site 137
S1727
Q
A
D
S
L
M
T
S
S
A
F
D
T
S
Q
Site 138
S1728
A
D
S
L
M
T
S
S
A
F
D
T
S
Q
V
Site 139
T1732
M
T
S
S
A
F
D
T
S
Q
V
K
D
K
R
Site 140
S1733
T
S
S
A
F
D
T
S
Q
V
K
D
K
R
D
Site 141
T1741
Q
V
K
D
K
R
D
T
I
N
G
R
F
Q
K
Site 142
S1751
G
R
F
Q
K
I
K
S
M
A
A
S
R
R
A
Site 143
S1755
K
I
K
S
M
A
A
S
R
R
A
K
L
N
E
Site 144
S1763
R
R
A
K
L
N
E
S
H
R
L
H
Q
F
F
Site 145
S1778
R
D
M
D
D
E
E
S
W
I
K
E
K
K
L
Site 146
S1789
E
K
K
L
L
V
G
S
E
D
Y
G
R
D
L
Site 147
Y1792
L
L
V
G
S
E
D
Y
G
R
D
L
T
G
V
Site 148
T1797
E
D
Y
G
R
D
L
T
G
V
Q
N
L
R
K
Site 149
T1826
A
I
Q
G
V
L
D
T
G
K
K
L
S
D
D
Site 150
S1831
L
D
T
G
K
K
L
S
D
D
N
T
I
G
K
Site 151
T1835
K
K
L
S
D
D
N
T
I
G
K
E
E
I
Q
Site 152
S1869
R
G
Q
R
L
E
E
S
L
E
Y
Q
Q
F
V
Site 153
Y1872
R
L
E
E
S
L
E
Y
Q
Q
F
V
A
N
V
Site 154
T1891
A
W
I
N
E
K
M
T
L
V
A
S
E
D
Y
Site 155
S1895
E
K
M
T
L
V
A
S
E
D
Y
G
D
T
L
Site 156
T1901
A
S
E
D
Y
G
D
T
L
A
A
I
Q
G
L
Site 157
T1917
K
K
H
E
A
F
E
T
D
F
T
V
H
K
D
Site 158
T1920
E
A
F
E
T
D
F
T
V
H
K
D
R
V
N
Site 159
T1931
D
R
V
N
D
V
C
T
N
G
Q
D
L
I
K
Site 160
S1949
H
H
E
E
N
I
S
S
K
M
K
G
L
N
G
Site 161
S1959
K
G
L
N
G
K
V
S
D
L
E
K
A
A
A
Site 162
S1998
W
I
G
E
K
E
N
S
L
K
T
D
D
Y
G
Site 163
Y2004
N
S
L
K
T
D
D
Y
G
R
D
L
S
S
V
Site 164
S2009
D
D
Y
G
R
D
L
S
S
V
Q
T
L
L
T
Site 165
S2010
D
Y
G
R
D
L
S
S
V
Q
T
L
L
T
K
Site 166
T2013
R
D
L
S
S
V
Q
T
L
L
T
K
Q
E
T
Site 167
T2016
S
S
V
Q
T
L
L
T
K
Q
E
T
F
D
A
Site 168
T2020
T
L
L
T
K
Q
E
T
F
D
A
G
L
Q
A
Site 169
S2060
A
I
E
A
R
H
A
S
L
M
K
R
W
S
Q
Site 170
S2066
A
S
L
M
K
R
W
S
Q
L
L
A
N
S
A
Site 171
S2072
W
S
Q
L
L
A
N
S
A
A
R
K
K
K
L
Site 172
S2084
K
K
L
L
E
A
Q
S
H
F
R
K
V
E
D
Site 173
S2101
L
T
F
A
K
K
A
S
A
F
N
S
W
F
E
Site 174
S2105
K
K
A
S
A
F
N
S
W
F
E
N
A
E
E
Site 175
T2115
E
N
A
E
E
D
L
T
D
P
V
R
C
N
S
Site 176
S2122
T
D
P
V
R
C
N
S
L
E
E
I
K
A
L
Site 177
S2138
E
A
H
D
A
F
R
S
S
L
S
S
A
Q
A
Site 178
S2139
A
H
D
A
F
R
S
S
L
S
S
A
Q
A
D
Site 179
S2141
D
A
F
R
S
S
L
S
S
A
Q
A
D
F
N
Site 180
S2142
A
F
R
S
S
L
S
S
A
Q
A
D
F
N
Q
Site 181
S2159
E
L
D
R
Q
I
K
S
F
R
V
A
S
N
P
Site 182
Y2167
F
R
V
A
S
N
P
Y
T
W
F
T
M
E
A
Site 183
T2168
R
V
A
S
N
P
Y
T
W
F
T
M
E
A
L
Site 184
Y2227
W
I
Q
E
T
R
T
Y
L
L
D
G
S
C
M
Site 185
S2232
R
T
Y
L
L
D
G
S
C
M
V
E
E
S
G
Site 186
S2238
G
S
C
M
V
E
E
S
G
T
L
E
S
Q
L
Site 187
T2240
C
M
V
E
E
S
G
T
L
E
S
Q
L
E
A
Site 188
S2260
Q
E
I
R
A
M
R
S
Q
L
K
K
I
E
D
Site 189
Y2282
A
L
I
L
D
N
K
Y
T
E
H
S
T
V
G
Site 190
T2317
Q
Q
I
Q
A
R
N
T
T
G
V
T
E
E
A
Site 191
T2318
Q
I
Q
A
R
N
T
T
G
V
T
E
E
A
L
Site 192
S2340
K
H
F
D
K
D
K
S
G
R
L
N
H
Q
E
Site 193
S2350
L
N
H
Q
E
F
K
S
C
L
R
S
L
G
Y
Site 194
S2354
E
F
K
S
C
L
R
S
L
G
Y
D
L
P
M
Site 195
Y2357
S
C
L
R
S
L
G
Y
D
L
P
M
V
E
E
Site 196
T2377
E
F
E
A
I
L
D
T
V
D
P
N
R
D
G
Site 197
S2387
P
N
R
D
G
H
V
S
L
Q
E
Y
M
A
F
Site 198
T2400
A
F
M
I
S
R
E
T
E
N
V
K
S
S
E
Site 199
S2405
R
E
T
E
N
V
K
S
S
E
E
I
E
S
A
Site 200
S2406
E
T
E
N
V
K
S
S
E
E
I
E
S
A
F
Site 201
S2411
K
S
S
E
E
I
E
S
A
F
R
A
L
S
S
Site 202
S2417
E
S
A
F
R
A
L
S
S
E
G
K
P
Y
V
Site 203
S2418
S
A
F
R
A
L
S
S
E
G
K
P
Y
V
T
Site 204
Y2423
L
S
S
E
G
K
P
Y
V
T
K
E
E
L
Y
Site 205
T2425
S
E
G
K
P
Y
V
T
K
E
E
L
Y
Q
N
Site 206
Y2430
Y
V
T
K
E
E
L
Y
Q
N
L
T
R
E
Q
Site 207
T2434
E
E
L
Y
Q
N
L
T
R
E
Q
A
D
Y
C
Site 208
Y2440
L
T
R
E
Q
A
D
Y
C
V
S
H
M
K
P
Site 209
Y2448
C
V
S
H
M
K
P
Y
V
D
G
K
G
R
E
Site 210
Y2462
E
L
P
T
A
F
D
Y
V
E
F
T
R
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation