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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BMPR2
Full Name:
Bone morphogenetic protein receptor type-2
Alias:
BMP type II receptor; BMPR3; BMPR-II; BMR2; Bone morphogenetic protein receptor type II precursor; Bone morphogenetic protein receptor, type II; BRK-3; EC 2.7.11.30; PPH1; T-ALK
Type:
EC 2.7.11.30; Cell cycle regulation; Receptor Ser/Thr kinase;
TKL
group; STKR family; Type2 subfamily
Mass (Da):
115201
Number AA:
1038
UniProt ID:
Q13873
International Prot ID:
IPI00783156
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0009952
GO:0009267
Phosida
TranscriptoNet
STRING
Kinexus Products
Bone morphogenetic protein receptor type-2 S375 phosphosite-specific antibody AB-PK544#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK544#Bone morphogenetic protein receptor type-2 (A372-G378, human) pS375 phosphopeptide - Powder PE-04AIS99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AIS99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T176
C
F
G
Y
R
M
L
T
G
D
R
K
Q
G
L
Site 2
S194
N
M
M
E
A
A
A
S
E
P
S
L
D
L
D
Site 3
Y214
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
Site 4
Y218
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
R
Site 5
S221
Y
G
A
V
Y
K
G
S
L
D
E
R
P
V
A
Site 6
Y247
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
Site 7
T268
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
Site 8
Y275
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
Site 9
S286
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
Site 10
Y290
P
N
G
S
L
C
K
Y
L
S
L
H
T
S
D
Site 11
S292
G
S
L
C
K
Y
L
S
L
H
T
S
D
W
V
Site 12
S296
K
Y
L
S
L
H
T
S
D
W
V
S
S
C
R
Site 13
S300
L
H
T
S
D
W
V
S
S
C
R
L
A
H
S
Site 14
S301
H
T
S
D
W
V
S
S
C
R
L
A
H
S
V
Site 15
S307
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
Site 16
Y314
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R
Site 17
T317
R
G
L
A
Y
L
H
T
E
L
P
R
G
D
H
Site 18
Y325
E
L
P
R
G
D
H
Y
K
P
A
I
S
H
R
Site 19
S330
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
Site 20
S336
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
Site 21
S350
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
Site 22
S355
V
I
S
D
F
G
L
S
M
R
L
T
G
N
R
Site 23
T359
F
G
L
S
M
R
L
T
G
N
R
L
V
R
P
Site 24
S375
E
E
D
N
A
A
I
S
E
V
G
T
I
R
Y
Bone morphogenetic protein receptor type-2 S375 phosphosite-specific antibody AB-PK544#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK544#Bone morphogenetic protein receptor type-2 (A372-G378, human) pS375 phosphopeptide - Powder PE-04AIS99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AIS99
Site 25
T379
A
A
I
S
E
V
G
T
I
R
Y
M
A
P
E
Site 26
Y382
S
E
V
G
T
I
R
Y
M
A
P
E
V
L
E
Site 27
S399
V
N
L
R
D
C
E
S
A
L
K
Q
V
D
M
Site 28
S428
T
D
L
F
P
G
E
S
V
P
E
Y
Q
M
A
Site 29
Y432
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
Site 30
T445
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
Site 31
S470
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
Site 32
T479
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
Site 33
T493
Q
D
A
E
A
R
L
T
A
Q
C
A
E
E
R
Site 34
S513
M
I
W
E
R
N
K
S
V
S
P
T
V
N
P
Site 35
S515
W
E
R
N
K
S
V
S
P
T
V
N
P
M
S
Site 36
T517
R
N
K
S
V
S
P
T
V
N
P
M
S
T
A
Site 37
S522
S
P
T
V
N
P
M
S
T
A
M
Q
N
E
R
Site 38
S532
M
Q
N
E
R
N
L
S
H
N
R
R
V
P
K
Site 39
Y543
R
V
P
K
I
G
P
Y
P
D
Y
S
S
S
S
Site 40
Y546
K
I
G
P
Y
P
D
Y
S
S
S
S
Y
I
E
Site 41
S547
I
G
P
Y
P
D
Y
S
S
S
S
Y
I
E
D
Site 42
S548
G
P
Y
P
D
Y
S
S
S
S
Y
I
E
D
S
Site 43
S549
P
Y
P
D
Y
S
S
S
S
Y
I
E
D
S
I
Site 44
S550
Y
P
D
Y
S
S
S
S
Y
I
E
D
S
I
H
Site 45
Y551
P
D
Y
S
S
S
S
Y
I
E
D
S
I
H
H
Site 46
S555
S
S
S
Y
I
E
D
S
I
H
H
T
D
S
I
Site 47
T559
I
E
D
S
I
H
H
T
D
S
I
V
K
N
I
Site 48
S561
D
S
I
H
H
T
D
S
I
V
K
N
I
S
S
Site 49
S567
D
S
I
V
K
N
I
S
S
E
H
S
M
S
S
Site 50
S568
S
I
V
K
N
I
S
S
E
H
S
M
S
S
T
Site 51
S571
K
N
I
S
S
E
H
S
M
S
S
T
P
L
T
Site 52
S573
I
S
S
E
H
S
M
S
S
T
P
L
T
I
G
Site 53
S574
S
S
E
H
S
M
S
S
T
P
L
T
I
G
E
Site 54
T575
S
E
H
S
M
S
S
T
P
L
T
I
G
E
K
Site 55
T578
S
M
S
S
T
P
L
T
I
G
E
K
N
R
N
Site 56
S586
I
G
E
K
N
R
N
S
I
N
Y
E
R
Q
Q
Site 57
Y589
K
N
R
N
S
I
N
Y
E
R
Q
Q
A
Q
A
Site 58
S600
Q
A
Q
A
R
I
P
S
P
E
T
S
V
T
S
Site 59
T603
A
R
I
P
S
P
E
T
S
V
T
S
L
S
T
Site 60
S604
R
I
P
S
P
E
T
S
V
T
S
L
S
T
N
Site 61
T606
P
S
P
E
T
S
V
T
S
L
S
T
N
T
T
Site 62
S607
S
P
E
T
S
V
T
S
L
S
T
N
T
T
T
Site 63
S609
E
T
S
V
T
S
L
S
T
N
T
T
T
T
N
Site 64
T613
T
S
L
S
T
N
T
T
T
T
N
T
T
G
L
Site 65
T621
T
T
N
T
T
G
L
T
P
S
T
G
M
T
T
Site 66
S623
N
T
T
G
L
T
P
S
T
G
M
T
T
I
S
Site 67
T627
L
T
P
S
T
G
M
T
T
I
S
E
M
P
Y
Site 68
S630
S
T
G
M
T
T
I
S
E
M
P
Y
P
D
E
Site 69
Y634
T
T
I
S
E
M
P
Y
P
D
E
T
N
L
H
Site 70
T638
E
M
P
Y
P
D
E
T
N
L
H
T
T
N
V
Site 71
T665
L
T
E
E
D
L
E
T
N
K
L
D
P
K
E
Site 72
S680
V
D
K
N
L
K
E
S
S
D
E
N
L
M
E
Site 73
S681
D
K
N
L
K
E
S
S
D
E
N
L
M
E
H
Site 74
S689
D
E
N
L
M
E
H
S
L
K
Q
F
S
G
P
Site 75
S694
E
H
S
L
K
Q
F
S
G
P
D
P
L
S
S
Site 76
S700
F
S
G
P
D
P
L
S
S
T
S
S
S
L
L
Site 77
S701
S
G
P
D
P
L
S
S
T
S
S
S
L
L
Y
Site 78
T702
G
P
D
P
L
S
S
T
S
S
S
L
L
Y
P
Site 79
S703
P
D
P
L
S
S
T
S
S
S
L
L
Y
P
L
Site 80
Y708
S
T
S
S
S
L
L
Y
P
L
I
K
L
A
V
Site 81
T724
A
T
G
Q
Q
D
F
T
Q
T
A
N
G
Q
A
Site 82
Y743
D
V
L
P
T
Q
I
Y
P
L
P
K
Q
Q
N
Site 83
T756
Q
N
L
P
K
R
P
T
S
L
P
L
N
T
K
Site 84
S757
N
L
P
K
R
P
T
S
L
P
L
N
T
K
N
Site 85
S775
E
P
R
L
K
F
G
S
K
H
K
S
N
L
K
Site 86
S779
K
F
G
S
K
H
K
S
N
L
K
Q
V
E
T
Site 87
S815
G
V
A
G
R
N
H
S
V
N
S
H
A
A
T
Site 88
S818
G
R
N
H
S
V
N
S
H
A
A
T
T
Q
Y
Site 89
T822
S
V
N
S
H
A
A
T
T
Q
Y
A
N
G
T
Site 90
T836
T
V
L
S
G
Q
T
T
N
I
V
T
H
R
A
Site 91
S862
D
T
R
L
N
I
N
S
S
P
D
E
H
E
P
Site 92
S863
T
R
L
N
I
N
S
S
P
D
E
H
E
P
L
Site 93
T900
R
P
L
E
G
G
R
T
N
S
N
N
N
N
S
Site 94
S902
L
E
G
G
R
T
N
S
N
N
N
N
S
N
P
Site 95
S907
T
N
S
N
N
N
N
S
N
P
C
S
E
Q
D
Site 96
S911
N
N
N
S
N
P
C
S
E
Q
D
V
L
A
Q
Site 97
S940
R
R
A
Q
R
P
N
S
L
D
L
S
A
T
N
Site 98
S944
R
P
N
S
L
D
L
S
A
T
N
V
L
D
G
Site 99
T946
N
S
L
D
L
S
A
T
N
V
L
D
G
S
S
Site 100
S952
A
T
N
V
L
D
G
S
S
I
Q
I
G
E
S
Site 101
S959
S
S
I
Q
I
G
E
S
T
Q
D
G
K
S
G
Site 102
T960
S
I
Q
I
G
E
S
T
Q
D
G
K
S
G
S
Site 103
S965
E
S
T
Q
D
G
K
S
G
S
G
E
K
I
K
Site 104
S967
T
Q
D
G
K
S
G
S
G
E
K
I
K
K
R
Site 105
T977
K
I
K
K
R
V
K
T
P
Y
S
L
K
R
W
Site 106
Y979
K
K
R
V
K
T
P
Y
S
L
K
R
W
R
P
Site 107
S980
K
R
V
K
T
P
Y
S
L
K
R
W
R
P
S
Site 108
S987
S
L
K
R
W
R
P
S
T
W
V
I
S
T
E
Site 109
T988
L
K
R
W
R
P
S
T
W
V
I
S
T
E
S
Site 110
S1005
C
E
V
N
N
N
G
S
N
R
A
V
H
S
K
Site 111
S1011
G
S
N
R
A
V
H
S
K
S
S
T
A
V
Y
Site 112
S1013
N
R
A
V
H
S
K
S
S
T
A
V
Y
L
A
Site 113
T1015
A
V
H
S
K
S
S
T
A
V
Y
L
A
E
G
Site 114
Y1018
S
K
S
S
T
A
V
Y
L
A
E
G
G
T
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation